{"id":61610,"date":"2021-04-19T17:16:03","date_gmt":"2021-04-19T15:16:03","guid":{"rendered":"https:\/\/wpcalc.com\/?p=61610"},"modified":"2025-05-20T10:27:51","modified_gmt":"2025-05-20T07:27:51","slug":"carboplatin-auc-dose","status":"publish","type":"post","link":"https:\/\/wpcalc.com\/en\/medical\/carboplatin-auc-dose\/","title":{"rendered":"Carboplatin AUC Dose Calculator"},"content":{"rendered":"<section class=\"not-prose calculator-box\" aria-labelledby=\"calculator-title\"><div class=\"flex items-baseline sm:items-center justify-between gap-2 sm:gap-3\"><div class=\"flex flex-col sm:flex-row sm:items-center gap-2\"><span class=\"icon icon-calculator text-primary-700! text-base! dark:text-primary-300!\" aria-hidden=\"true\"><\/span><h2 class=\"text-lg font-display font-bold\">Carboplatin AUC Dose Calculator<\/h2><\/div><div class=\"relative group inline-block\">\n  <button class=\"favorite\" id=\"favorite\" data-favorite-id=\"61610\" data-favorite-title=\"Carboplatin AUC Dose\" data-favorite-url=\"https:\/\/wpcalc.com\/en\/medical\/carboplatin-auc-dose\/\" data-favorite-excerpt=\"This calculator determines the appropriate dose of carboplatin chemotherapy based on the Calvert formula using patient-specific data such as gender, age, weight, serum creatinine, and the target AUC. It\u2019s a useful tool for oncologists and pharmacists to personalize cancer treatment by estimating the Glomerular Filtration Rate (GFR) and calculating the precise carboplatin dosage.\" aria-label=\"Add to Favorites\" data-favorite-icon=\"icon icon-pharmacology\">\n    <span class=\"icon icon-shape-star-empty\"><\/span>\n  <\/button>\n  <div class=\"absolute right-full -translate-y-1\/2 top-1\/2 mr-2 w-max max-w-xs px-3 py-2 bg-gray-800 text-white text-xs rounded shadow-lg opacity-0 group-hover:opacity-100 transition-opacity duration-200 z-10 pointer-events-none\">\n   <span class=\"favorite-tooltip\" id=\"favorite-tooltip\"><\/span>\n  <\/div>\n<\/div><\/div><form action=\"https:\/\/wpcalc.com\/en\/medical\/carboplatin-auc-dose\/\" method=\"POST\" class=\"calculator\" id=\"calculator-61610\" data-post=\"61610\"><fieldset class=\"fieldset-input is-1\"><legend class=\"sr-only\">Input Fields<\/legend><div class=\"field is-single\" id=\"input-1\"><label for=\"field-1\">Gender<\/label><div class=\"grid grid-cols-1\"><select id=\"field-1\" name=\"gender\"><option value=\"1\">Male<\/option><option value=\"0.85\">Female<\/option><\/select><svg class=\"pointer-events-none col-start-1 row-start-1 mr-2 size-5 self-center justify-self-end text-gray-500 sm:size-4\" viewBox=\"0 0 16 16\" fill=\"currentColor\" aria-hidden=\"true\" data-slot=\"icon\">\n              <path fill-rule=\"evenodd\" d=\"M4.22 6.22a.75.75 0 0 1 1.06 0L8 8.94l2.72-2.72a.75.75 0 1 1 1.06 1.06l-3.25 3.25a.75.75 0 0 1-1.06 0L4.22 7.28a.75.75 0 0 1 0-1.06Z\" clip-rule=\"evenodd\" \/>\n            <\/svg><\/div><\/div><div class=\"field\" id=\"input-2\"><label for=\"field-2\">Age<\/label><input type=\"number\" name=\"age\" id=\"field-2\" placeholder=\"e.g. 25\" step=\"any\" value=\"25\"\/><div class=\"unit\">years<\/div><\/div><div class=\"field\" id=\"input-3\"><label for=\"field-3\">Weight<\/label><div class=\"field-group\"><input type=\"number\" name=\"weight\" id=\"field-3\" placeholder=\"e.g. 70\" step=\"any\" value=\"70\"\/><div class=\"grid grid-cols-1\"><select id=\"field-4\" name=\"unit\" aria-label=\"Unit\"><option value=\"1\">kg<\/option><option value=\"0.453592\">lb<\/option><\/select><svg class=\"pointer-events-none col-start-1 row-start-1 mr-2 size-5 self-center justify-self-end text-gray-500 sm:size-4\" viewBox=\"0 0 16 16\" fill=\"currentColor\" aria-hidden=\"true\" data-slot=\"icon\">\n              <path fill-rule=\"evenodd\" d=\"M4.22 6.22a.75.75 0 0 1 1.06 0L8 8.94l2.72-2.72a.75.75 0 1 1 1.06 1.06l-3.25 3.25a.75.75 0 0 1-1.06 0L4.22 7.28a.75.75 0 0 1 0-1.06Z\" clip-rule=\"evenodd\" \/>\n            <\/svg><\/div><\/div><\/div><div class=\"field\" id=\"input-4\"><label for=\"field-5\">Serum Creatinine<\/label><input type=\"number\" name=\"serum_creatinine\" id=\"field-5\" placeholder=\"e.g. 1.0\" step=\"any\" value=\"1\"\/><div class=\"unit\">mg\/dL<\/div><\/div><div class=\"field\" id=\"input-5\"><label for=\"field-6\">Target AUC<\/label><input type=\"number\" name=\"target_auc\" id=\"field-6\" placeholder=\"e.g. 5\" step=\"any\" value=\"5\"\/><div class=\"unit\">mg\/ml\/min<\/div><\/div><\/fieldset><div class=\"buttons\"><button type=\"submit\" data-text=\"Re-Calculate\" id=\"calculate-button\" data-post=\"61610\">Calculate<\/button><button type=\"reset\">Reset<\/button><\/div><div class=\"field is-checkbox hidden!\" id=\"field-auto-calc\"><input type=\"checkbox\" id=\"auto-calc\"><label for=\"auto-calc\">Calculate automatically<\/label><small>If enabled, the result will update automatically when you change any value.<\/small><\/div><div class=\"fieldset-result is-hidden\" aria-labelledby=\"result-title\" aria-live=\"polite\" role=\"region\"> <h3 class=\"result-title bg-gradient-to-r from-primary-50 to-gray-50 dark:from-primary-900 dark:to-gray-800\" id=\"result-title\"><span class=\"icon icon-s-pulse\" aria-hidden=\"true\"><\/span> Your Results<\/h3><div class=\"result-box\"><div class=\"field-result\" id=\"output-1\"><span class=\"field-title\"><span>GFR<\/span><\/span><span class=\"field-value\" id=\"result-1\"><\/span><button class=\"copy-result\" data-tooltip=\"Copy Result\"><span class=\"copy-icon icon icon-document-copy\"><\/span><\/button><\/div><div class=\"field-result\" id=\"output-2\"><span class=\"field-title\"><span>Carboplatin Dose<\/span><\/span><span class=\"field-value\" id=\"result-2\"><\/span><button class=\"copy-result\" data-tooltip=\"Copy Result\"><span class=\"copy-icon icon icon-document-copy\"><\/span><\/button><\/div><\/div><\/div><a href=\"#respond\" class=\"hidden transition-opacity duration-300 opacity-0 w-50 text-sm justify-center items-center gap-2 px-4 py-2 rounded bg-gray-200 text-gray-700 hover:bg-gray-300\" id=\"leave-comment\"><span class=\"icon icon-comments\" aria-hidden=\"true\"><\/span>Leave a Comment<\/a><\/form><\/section><section id=\"calc-reactions\" class=\"not-prose hidden my-12 bg-gradient-to-r from-primary-50 to-gray-50 border border-indigo-100 rounded-xl px-6 py-4 shadow-sm\" data-post=\"61610\" aria-live=\"polite\"><h2 class=\"text-sm text-gray-500 text-center mb-2\">How did this result make you feel?<\/h2><div class=\"grid grid-cols-3 sm:flex sm:flex-row sm:justify-around gap-4 sm:items-center sm:flex-wrap\"><button class=\"reaction-btn flex flex-col items-center gap-1 text-sm text-gray-700 hover:text-primary-600 cursor-pointer transition-transform hover:scale-105\" data-reaction=\"like\"><span class=\"reaction-count\" data-reaction-count=\"like\">0<\/span><span class=\"reaction text-3xl\">\ud83d\ude00 <\/span><span class=\"reaction-description font-medium\">Like <\/span><\/button><button class=\"reaction-btn flex flex-col items-center gap-1 text-sm text-gray-700 hover:text-primary-600 cursor-pointer transition-transform hover:scale-105\" data-reaction=\"helpful\"><span class=\"reaction-count\" data-reaction-count=\"helpful\">0<\/span><span class=\"reaction text-3xl\">\ud83d\udca1 <\/span><span class=\"reaction-description font-medium\">Helpful <\/span><\/button><button class=\"reaction-btn flex flex-col items-center gap-1 text-sm text-gray-700 hover:text-primary-600 cursor-pointer transition-transform hover:scale-105\" data-reaction=\"confused\"><span class=\"reaction-count\" data-reaction-count=\"confused\">0<\/span><span class=\"reaction text-3xl\">\ud83d\ude15 <\/span><span class=\"reaction-description font-medium\">Confused <\/span><\/button><button class=\"reaction-btn flex flex-col items-center gap-1 text-sm text-gray-700 hover:text-primary-600 cursor-pointer transition-transform hover:scale-105\" data-reaction=\"disappointed\"><span class=\"reaction-count\" data-reaction-count=\"disappointed\">0<\/span><span class=\"reaction text-3xl\">\ud83d\ude1e <\/span><span class=\"reaction-description font-medium\">Disappointed <\/span><\/button><button class=\"reaction-btn flex flex-col items-center gap-1 text-sm text-gray-700 hover:text-primary-600 cursor-pointer transition-transform hover:scale-105\" data-reaction=\"inaccurate\"><span class=\"reaction-count\" data-reaction-count=\"inaccurate\">0<\/span><span class=\"reaction text-3xl\">\u274c <\/span><span class=\"reaction-description font-medium\">Inaccurate <\/span><\/button><\/div><div id=\"reaction-message\" class=\"hidden mt-8 rounded-md border border-primary-100 bg-white\/50 backdrop-blur-sm px-4 py-2 text-sm text-center shadow-sm\"><\/div><\/section><ins class=\"adsbygoogle\"\n     style=\"display:block; text-align:center; margin: 32px 0;\"\n     data-ad-layout=\"in-article\"\n     data-ad-format=\"fluid\"\n     data-ad-client=\"ca-pub-1721569815777345\"\n     data-ad-slot=\"6317458308\"><\/ins>\n<script>\n     (adsbygoogle = window.adsbygoogle || []).push({});\n<\/script>\n<section class=\"formula-box\" aria-labelledby=\"formula-title\">\r\n\t<div id=\"formula-title\" class=\"not-prose font-display mb-4\"><span class=\"icon icon-formula\" aria-hidden=\"true\"><\/span><h2>Calvert Formula for Carboplatin Dose<\/h2><\/div>\r\n\t<figure class=\"not-prose formula\">\r\n\t\t<figcaption class=\"formula-title\">Formula<\/figcaption>\r\n\t\t<div class=\"text-base text-gray-800\" id=\"formula\">\\[\\text{GFR}_{\\text{Male}} = \\left( \\frac{140 &#8211; \\text{age}}{\\text{serum creatinine}} \\right) \\times \\left( \\frac{\\text{weight (kg)}}{72} \\right) \\]\\[\\text{GFR}_{\\text{Female}} = \\left( \\frac{140 &#8211; \\text{age}}{\\text{serum creatinine}} \\right) \\times 0.85 \\times \\left( \\frac{\\text{weight (kg)}}{72} \\right) \\]\\[\\text{Carboplatin Dose} = \\text{Target AUC} \\times (\\text{GFR} + 25)\\]<\/div>\r\n\t<\/figure>\r\n\t<br \/>\n<strong>Explanation:<\/strong><\/p>\n<ul>\n<li>GFR is estimated using the Cockcroft-Gault equation.<\/li>\n<li>The Calvert formula calculates carboplatin dosage based on GFR and a desired AUC (area under the concentration-time curve).<\/li>\n<li>Gender affects the GFR factor (0.85 for females).<\/li>\n<\/ul>\n<p>\r\n<\/section>\n<p>The Calvert formula is widely used in oncology to calculate carboplatin dosage based on renal function and target AUC. This ensures safe and effective dosing, especially important due to carboplatin\u2019s nephrotoxicity. The input includes gender (for GFR adjustment), age, weight, and serum creatinine to estimate GFR. The final dose is tailored by multiplying GFR + 25 by the target AUC. For example, if a 60-year-old woman weighing 65 kg has a serum creatinine of 1.0 mg\/dL and the target AUC is 5, her GFR would be calculated and then used to determine the appropriate dose.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>This calculator determines the appropriate dose of carboplatin chemotherapy based on the Calvert formula using patient-specific data such as gender, age, weight, serum creatinine, and the target AUC. It\u2019s a useful tool for oncologists and pharmacists to personalize cancer treatment by estimating the Glomerular Filtration Rate (GFR) and calculating the precise carboplatin dosage.<\/p>\n","protected":false},"author":70,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[8],"tags":[32],"class_list":["post-61610","post","type-post","status-publish","format-standard","hentry","category-medical","tag-pharmacology"],"acf":[],"_links":{"self":[{"href":"https:\/\/wpcalc.com\/en\/wp-json\/wp\/v2\/posts\/61610","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wpcalc.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wpcalc.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wpcalc.com\/en\/wp-json\/wp\/v2\/users\/70"}],"replies":[{"embeddable":true,"href":"https:\/\/wpcalc.com\/en\/wp-json\/wp\/v2\/comments?post=61610"}],"version-history":[{"count":1,"href":"https:\/\/wpcalc.com\/en\/wp-json\/wp\/v2\/posts\/61610\/revisions"}],"predecessor-version":[{"id":64646,"href":"https:\/\/wpcalc.com\/en\/wp-json\/wp\/v2\/posts\/61610\/revisions\/64646"}],"wp:attachment":[{"href":"https:\/\/wpcalc.com\/en\/wp-json\/wp\/v2\/media?parent=61610"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wpcalc.com\/en\/wp-json\/wp\/v2\/categories?post=61610"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wpcalc.com\/en\/wp-json\/wp\/v2\/tags?post=61610"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}