{"id":61610,"date":"2021-04-19T17:16:03","date_gmt":"2021-04-19T15:16:03","guid":{"rendered":"https:\/\/wpcalc.com\/?p=61610"},"modified":"2026-10-01T13:22:42","modified_gmt":"2026-10-01T10:22:42","slug":"carboplatin-auc-dose","status":"publish","type":"post","link":"https:\/\/wpcalc.com\/en\/medical\/carboplatin-auc-dose\/","title":{"rendered":"Carboplatin AUC Dose Calculator"},"content":{"rendered":"<section class=\"not-prose calculator-box\" aria-labelledby=\"calculator-title\"><div class=\"flex items-baseline sm:items-center justify-between gap-2 sm:gap-3\"><div class=\"flex flex-col sm:flex-row sm:items-center gap-2\"><span class=\"icon icon-calculator text-primary-700! text-base! dark:text-primary-300!\" aria-hidden=\"true\"><\/span><h2 id=\"calculator-title\" class=\"text-lg font-display font-bold\">Calculate Carboplatin AUC Dose<\/h2><\/div><div class=\"calcdash-favorite group\">\n  <button type=\"button\" class=\"favorite\" id=\"favorite\" data-favorite-id=\"61610\" data-favorite-title=\"Carboplatin AUC Dose\" data-favorite-url=\"https:\/\/wpcalc.com\/en\/medical\/carboplatin-auc-dose\/\" data-favorite-excerpt=\"Calculate the carboplatin dose with the Calvert formula. Enter gender, age, weight, serum creatinine and target AUC to estimate GFR (Cockcroft-Gault) and the dose in mg.\" aria-label=\"Add to Favorites\" data-favorite-icon=\"icon icon-pharmacology\">\n    <span class=\"icon icon-shape-star-empty\" aria-hidden=\"true\"><\/span>\n  <\/button>\n  <div class=\"calcdash-favorite__tip\" aria-hidden=\"true\">\n   <span class=\"favorite-tooltip\" id=\"favorite-tooltip\"><\/span>\n  <\/div>\n  <span class=\"sr-only\" role=\"status\" id=\"favorite-status\"><\/span>\n<\/div><\/div><form action=\"https:\/\/wpcalc.com\/en\/medical\/carboplatin-auc-dose\/\" method=\"POST\" class=\"calculator\" id=\"calculator-61610\" data-post=\"61610\"><fieldset class=\"fieldset-input is-1\"><legend class=\"sr-only\">Input Fields<\/legend><div class=\"field is-single\" id=\"input-1\"><label for=\"field-1\">Gender<\/label><div class=\"grid grid-cols-1\"><select id=\"field-1\" name=\"gender\"><option value=\"1\">Male<\/option><option value=\"0.85\">Female<\/option><\/select><svg class=\"pointer-events-none col-start-1 row-start-1 mr-2 size-5 self-center justify-self-end text-gray-500 sm:size-4\" viewBox=\"0 0 16 16\" fill=\"currentColor\" aria-hidden=\"true\" data-slot=\"icon\">\n              <path fill-rule=\"evenodd\" d=\"M4.22 6.22a.75.75 0 0 1 1.06 0L8 8.94l2.72-2.72a.75.75 0 1 1 1.06 1.06l-3.25 3.25a.75.75 0 0 1-1.06 0L4.22 7.28a.75.75 0 0 1 0-1.06Z\" clip-rule=\"evenodd\" \/>\n            <\/svg><\/div><\/div><div class=\"field\" id=\"input-2\"><label for=\"field-2\">Age<\/label><input type=\"number\" name=\"age\" id=\"field-2\" aria-describedby=\"calc-unit-2\" placeholder=\"e.g. 25\" step=\"any\" value=\"25\"\/><div class=\"unit\" id=\"calc-unit-2\">years<\/div><\/div><div class=\"field\" id=\"input-3\"><label for=\"field-3\">Weight<\/label><div class=\"field-group\"><input type=\"number\" name=\"weight\" id=\"field-3\" placeholder=\"e.g. 70\" step=\"any\" value=\"70\"\/><div class=\"grid grid-cols-1\"><select id=\"field-4\" name=\"unit\" aria-label=\"Unit\"><option value=\"1\">kg<\/option><option value=\"0.453592\">lb<\/option><\/select><svg class=\"pointer-events-none col-start-1 row-start-1 mr-2 size-5 self-center justify-self-end text-gray-500 sm:size-4\" viewBox=\"0 0 16 16\" fill=\"currentColor\" aria-hidden=\"true\" data-slot=\"icon\">\n              <path fill-rule=\"evenodd\" d=\"M4.22 6.22a.75.75 0 0 1 1.06 0L8 8.94l2.72-2.72a.75.75 0 1 1 1.06 1.06l-3.25 3.25a.75.75 0 0 1-1.06 0L4.22 7.28a.75.75 0 0 1 0-1.06Z\" clip-rule=\"evenodd\" \/>\n            <\/svg><\/div><\/div><\/div><div class=\"field\" id=\"input-4\"><label for=\"field-5\">Serum Creatinine<\/label><input type=\"number\" name=\"serum_creatinine\" id=\"field-5\" aria-describedby=\"calc-unit-5\" placeholder=\"e.g. 1.0\" step=\"any\" value=\"1\"\/><div class=\"unit\" id=\"calc-unit-5\">mg\/dL<\/div><\/div><div class=\"field\" id=\"input-5\"><label for=\"field-6\">Target AUC<\/label><input type=\"number\" name=\"target_auc\" id=\"field-6\" aria-describedby=\"calc-unit-6\" placeholder=\"e.g. 5\" step=\"any\" value=\"5\"\/><div class=\"unit\" id=\"calc-unit-6\">mg\/ml\/min<\/div><\/div><\/fieldset><div class=\"buttons\"><button type=\"submit\" data-text=\"Re-Calculate\" id=\"calculate-button\" data-post=\"61610\">Calculate<\/button><button type=\"reset\">Reset<\/button><\/div><div class=\"field is-checkbox hidden!\" id=\"field-auto-calc\"><input type=\"checkbox\" id=\"auto-calc\"><label for=\"auto-calc\">Calculate automatically<\/label><small>If enabled, the result will update automatically when you change any value.<\/small><\/div><div class=\"fieldset-result is-hidden\" aria-labelledby=\"result-title\" aria-live=\"polite\" role=\"region\"> <h3 class=\"result-title bg-gradient-to-r from-primary-50 to-gray-50 dark:from-primary-900 dark:to-gray-800\" id=\"result-title\"><span class=\"icon icon-s-pulse\" aria-hidden=\"true\"><\/span> Your Results<\/h3><div class=\"result-box\"><div class=\"field-result\" id=\"output-1\"><span class=\"field-title\"><span>GFR<\/span><\/span><span class=\"field-value\" id=\"result-1\"><\/span><button type=\"button\" class=\"copy-result\" data-tooltip=\"Copy Result\" aria-label=\"Copy Result\"><span class=\"copy-icon icon icon-document-copy\" aria-hidden=\"true\"><\/span><\/button><\/div><div class=\"field-result\" id=\"output-2\"><span class=\"field-title\"><span>Carboplatin Dose<\/span><\/span><span class=\"field-value\" id=\"result-2\"><\/span><button type=\"button\" class=\"copy-result\" data-tooltip=\"Copy Result\" aria-label=\"Copy Result\"><span class=\"copy-icon icon icon-document-copy\" aria-hidden=\"true\"><\/span><\/button><\/div><\/div><div class=\"result-actions\"><button type=\"button\" class=\"copy-link\"><svg viewBox=\"0 0 20 20\" fill=\"currentColor\" aria-hidden=\"true\"><path d=\"M12.232 4.232a2.5 2.5 0 0 1 3.536 3.536l-1.225 1.224a.75.75 0 0 0 1.061 1.06l1.224-1.224a4 4 0 0 0-5.656-5.656l-3 3a4 4 0 0 0 .225 5.865.75.75 0 0 0 .977-1.138 2.5 2.5 0 0 1-.142-3.667l3-3Z\"\/><path d=\"M11.603 7.963a.75.75 0 0 0-.977 1.138 2.5 2.5 0 0 1 .142 3.667l-3 3a2.5 2.5 0 0 1-3.536-3.536l1.225-1.224a.75.75 0 0 0-1.061-1.06l-1.224 1.224a4 4 0 1 0 5.656 5.656l3-3a4 4 0 0 0-.225-5.865Z\"\/><\/svg><span class=\"copy-link__text\">Copy link to this calculation<\/span><\/button><span class=\"sr-only\" role=\"status\" id=\"copy-link-status\"><\/span><\/div><\/div><a href=\"#respond\" class=\"hidden transition-opacity duration-300 opacity-0 w-50 text-sm justify-center items-center gap-2 px-4 py-2 rounded bg-gray-200 text-gray-700 hover:bg-gray-300\" id=\"leave-comment\"><span class=\"icon icon-comments\" aria-hidden=\"true\"><\/span>Leave a Comment<\/a><\/form><\/section><section id=\"calc-reactions\" class=\"not-prose hidden my-12 bg-gradient-to-r from-primary-50 to-gray-50 border border-indigo-100 rounded-xl px-6 py-4 shadow-sm\" data-post=\"61610\" aria-live=\"polite\" aria-labelledby=\"calc-reactions-title\"><p id=\"calc-reactions-title\" class=\"text-sm text-gray-500 text-center mb-2\">How did this result make you feel?<\/p><div role=\"group\" aria-labelledby=\"calc-reactions-title\" class=\"grid grid-cols-3 sm:flex sm:flex-row sm:justify-around gap-4 sm:items-center sm:flex-wrap\"><button type=\"button\" aria-pressed=\"false\" class=\"reaction-btn flex flex-col items-center gap-1 text-sm text-gray-700 hover:text-primary-600 cursor-pointer transition-transform hover:scale-105\" data-reaction=\"like\"><span class=\"reaction-count\" data-reaction-count=\"like\">0<\/span><span class=\"reaction text-3xl\" aria-hidden=\"true\">\ud83d\ude00 <\/span><span class=\"reaction-description font-medium\">Like <\/span><\/button><button type=\"button\" aria-pressed=\"false\" class=\"reaction-btn flex flex-col items-center gap-1 text-sm text-gray-700 hover:text-primary-600 cursor-pointer transition-transform hover:scale-105\" data-reaction=\"helpful\"><span class=\"reaction-count\" data-reaction-count=\"helpful\">0<\/span><span class=\"reaction text-3xl\" aria-hidden=\"true\">\ud83d\udca1 <\/span><span class=\"reaction-description font-medium\">Helpful <\/span><\/button><button type=\"button\" aria-pressed=\"false\" class=\"reaction-btn flex flex-col items-center gap-1 text-sm text-gray-700 hover:text-primary-600 cursor-pointer transition-transform hover:scale-105\" data-reaction=\"confused\"><span class=\"reaction-count\" data-reaction-count=\"confused\">0<\/span><span class=\"reaction text-3xl\" aria-hidden=\"true\">\ud83d\ude15 <\/span><span class=\"reaction-description font-medium\">Confused <\/span><\/button><button type=\"button\" aria-pressed=\"false\" class=\"reaction-btn flex flex-col items-center gap-1 text-sm text-gray-700 hover:text-primary-600 cursor-pointer transition-transform hover:scale-105\" data-reaction=\"disappointed\"><span class=\"reaction-count\" data-reaction-count=\"disappointed\">0<\/span><span class=\"reaction text-3xl\" aria-hidden=\"true\">\ud83d\ude1e <\/span><span class=\"reaction-description font-medium\">Disappointed <\/span><\/button><button type=\"button\" aria-pressed=\"false\" class=\"reaction-btn flex flex-col items-center gap-1 text-sm text-gray-700 hover:text-primary-600 cursor-pointer transition-transform hover:scale-105\" data-reaction=\"inaccurate\"><span class=\"reaction-count\" data-reaction-count=\"inaccurate\">0<\/span><span class=\"reaction text-3xl\" aria-hidden=\"true\">\u274c <\/span><span class=\"reaction-description font-medium\">Inaccurate <\/span><\/button><\/div><div id=\"reaction-message\" class=\"hidden mt-8 rounded-md border border-primary-100 bg-white\/50 backdrop-blur-sm px-4 py-2 text-sm text-center shadow-sm\"><\/div><\/section><div class=\"calcdash-ad not-prose calcdash-ad--calc_result calcdash-ad--in-article\"><ins class=\"adsbygoogle\" style=\"display:block\" data-ad-client=\"ca-pub-1721569815777345\" data-ad-slot=\"6317458308\" data-ad-layout=\"in-article\" data-ad-format=\"fluid\"><\/ins><script>(adsbygoogle = window.adsbygoogle || []).push({});<\/script><\/div>\n<style id=\"wpcoderpro-inline-1\">.formula-box {\r\n\tborder-bottom: none !important;\r\n}<\/style><section class=\"formula-box\" aria-labelledby=\"formula-title\">\r\n\t<div id=\"formula-title\" class=\"not-prose font-display mb-4\"><span class=\"icon icon-formula\" aria-hidden=\"true\"><\/span><h2>Carboplatin AUC Dose (Calvert Formula)<\/h2><\/div>\r\n\t<figure class=\"not-prose formula\">\r\n\t\t<figcaption class=\"formula-title\">Formula<\/figcaption>\r\n\t\t<div class=\"text-base text-gray-800\" id=\"formula\">\n\\[ \\text{GFR} = \\frac{(140 - \\text{age}) \\times \\text{weight (kg)}}{72 \\times \\text{serum creatinine (mg\/dL)}} \\times 0.85 \\;\\text{(if female)} \\]\n\\[ \\text{Carboplatin Dose (mg)} = \\text{Target AUC} \\times (\\text{GFR} + 25) \\]\n<\/div>\r\n\t<\/figure>\r\n\t<\/p>\n<p><strong>Where:<\/strong><\/p>\n<ul>\n<li>\\(\\text{GFR}\\) \u2014 glomerular filtration rate, estimated with the Cockcroft-Gault equation (mL\/min)<\/li>\n<li>\\(\\text{age}\\) \u2014 patient age in years<\/li>\n<li>\\(\\text{weight}\\) \u2014 body weight in kilograms<\/li>\n<li>\\(\\text{serum creatinine}\\) \u2014 serum creatinine in mg\/dL<\/li>\n<li>\\(0.85\\) \u2014 correction factor applied for female patients<\/li>\n<li>\\(\\text{Target AUC}\\) \u2014 desired area under the concentration-time curve (mg\/mL\u00b7min)<\/li>\n<li>\\(25\\) \u2014 non-renal clearance of carboplatin (mL\/min)<\/li>\n<\/ul>\n<p>The first equation estimates kidney function using the Cockcroft-Gault method; the second, the Calvert formula, converts that estimate plus the target drug exposure (AUC) into a carboplatin dose in milligrams.<\/p>\n<p>\r\n<\/section>\n<style id=\"wpcoderpro-inline-459\">.calculation-box {\r\n\tborder-bottom: none !important;\r\n}<\/style><section id=\"calculation\" class=\"calculation-box\" aria-labelledby=\"calculation-title\">\r\n\t<div id=\"calculation-title\" class=\"not-prose font-display\"><span class=\"icon icon-unordered-list\" aria-hidden=\"true\"><\/span><h2>Carboplatin AUC Dose \u2013 Calculation Example<\/h2><\/div>\r\n\r\n<\/p>\n<p><strong>Example:<\/strong> a 25-year-old man weighing 70 kg with a serum creatinine of 1.0 mg\/dL is prescribed carboplatin with a target AUC of 5.<\/p>\n<p>\\[ \\text{GFR} = \\frac{(140 - 25) \\times 70}{72 \\times 1.0} = \\frac{8050}{72} \\approx 111.81 \\;\\text{mL\/min} \\]<\/p>\n<p>\\[ \\text{Dose} = 5 \\times (111.81 + 25) = 5 \\times 136.81 \\approx 684.03 \\;\\text{mg} \\]<\/p>\n<p><strong>Result:<\/strong> GFR \u2248 111.81 mL\/min and a carboplatin dose of \u2248 684.03 mg. These match the calculator's default values, so you can reproduce them directly.<\/p>\n<p>\n\r\n<\/section>\n<h2>How to use the calculator<\/h2>\n<ol>\n<li>Select the patient's <strong>Gender<\/strong> (Male or Female). A factor of 0.85 is applied to the GFR estimate for female patients.<\/li>\n<li>Enter the patient's <strong>Age<\/strong> in years.<\/li>\n<li>Enter the <strong>Weight<\/strong> and choose the unit \u2014 <code>kg<\/code> or <code>lb<\/code>. Pounds are converted to kilograms automatically.<\/li>\n<li>Enter the <strong>Serum Creatinine<\/strong> value in mg\/dL from the patient's recent lab results.<\/li>\n<li>Enter the prescribed <strong>Target AUC<\/strong> in mg\/mL\u00b7min \u2014 commonly 4 to 7, depending on the treatment protocol.<\/li>\n<li>Read the results: the estimated <strong>GFR<\/strong> in mL\/min and the <strong>Carboplatin Dose<\/strong> in mg.<\/li>\n<\/ol>\n<h2>What the Calvert formula means<\/h2>\n<p>Carboplatin is a platinum-based chemotherapy drug used to treat ovarian, lung, head and neck, and several other cancers. Unlike most cytotoxic drugs, it is dosed to a target <em>area under the curve<\/em> (AUC) rather than to body surface area. The AUC describes total drug exposure over time: a higher AUC means more drug effect \u2014 and more toxicity.<\/p>\n<p>The Calvert formula, introduced in 1989, links the desired exposure to the dose that will produce it: dose = target AUC \u00d7 (GFR + 25). The term GFR represents renal clearance, since carboplatin is eliminated almost entirely by the kidneys, while the constant 25 mL\/min accounts for the small non-renal clearance. Because clearance varies widely between patients, this approach individualizes the dose far better than a fixed mg\/m\u00b2 regimen.<\/p>\n<p>The calculator estimates GFR with the Cockcroft-Gault equation, which derives creatinine clearance from age, weight, sex and serum creatinine. The female factor of 0.85 reflects women's on-average lower muscle mass and thus lower creatinine production.<\/p>\n<p>Interpreting the result: the output dose is the total amount of carboplatin (in mg) to administer for the chosen AUC, typically diluted and infused over 30\u201360 minutes. Typical targets are AUC 4\u20136 for combination regimens and AUC 5\u20137 for single-agent therapy, but the correct value always comes from the treatment protocol.<\/p>\n<h2>Assumptions, limitations and practical tips<\/h2>\n<ul>\n<li><strong>Renal function estimate only.<\/strong> Cockcroft-Gault is an approximation. In patients with unstable kidney function, extremes of weight, or very low muscle mass, a measured or radionuclide GFR is preferred for Calvert dosing \u2014 this is a known source of dosing error.<\/li>\n<li><strong>Creatinine units matter.<\/strong> The calculator expects serum creatinine in mg\/dL. If your lab reports \u00b5mol\/L, divide by 88.4 before entering the value.<\/li>\n<li><strong>Use actual body weight cautiously.<\/strong> Cockcroft-Gault was developed with actual body weight; in markedly obese or very underweight patients, many protocols use adjusted or ideal body weight instead. Check your institutional guideline.<\/li>\n<li><strong>Overestimation risk.<\/strong> Overestimating GFR leads to overdosing and myelosuppression, the dose-limiting toxicity of carboplatin. When in doubt, prescribers often cap the GFR estimate.<\/li>\n<li><strong>Not for carboplatin desensitization or high-dose protocols.<\/strong> Some settings use different formulas or measured clearance.<\/li>\n<li><strong>Clinical decision tool.<\/strong> This calculator supports verification and education; the final dose must be confirmed by an oncologist or clinical pharmacist against the specific protocol.<\/li>\n<\/ul>\n<p>For related calculations, see the <a href=\"https:\/\/wpcalc.com\/en\/medical\/half-life-time-medicine\/\">Half-Life Time calculator<\/a> to estimate drug elimination, the <a href=\"https:\/\/wpcalc.com\/en\/medical\/dosage-infusion\/\">Dosage Infusion calculator<\/a> for infusion rate calculations, or the <a href=\"https:\/\/wpcalc.com\/en\/medical\/dialysis-dose\/\">Dialysis Dose (Kt\/V) calculator<\/a> for assessing dialysis adequacy in patients with severe renal impairment.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Calculate the carboplatin dose with the Calvert formula. Enter gender, age, weight, serum creatinine and target AUC to estimate GFR (Cockcroft-Gault) and the dose in mg.<\/p>\n","protected":false},"author":70,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[8],"tags":[32],"class_list":["post-61610","post","type-post","status-publish","format-standard","hentry","category-medical","tag-pharmacology"],"acf":[],"_links":{"self":[{"href":"https:\/\/wpcalc.com\/en\/wp-json\/wp\/v2\/posts\/61610","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wpcalc.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wpcalc.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wpcalc.com\/en\/wp-json\/wp\/v2\/users\/70"}],"replies":[{"embeddable":true,"href":"https:\/\/wpcalc.com\/en\/wp-json\/wp\/v2\/comments?post=61610"}],"version-history":[{"count":3,"href":"https:\/\/wpcalc.com\/en\/wp-json\/wp\/v2\/posts\/61610\/revisions"}],"predecessor-version":[{"id":66309,"href":"https:\/\/wpcalc.com\/en\/wp-json\/wp\/v2\/posts\/61610\/revisions\/66309"}],"wp:attachment":[{"href":"https:\/\/wpcalc.com\/en\/wp-json\/wp\/v2\/media?parent=61610"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wpcalc.com\/en\/wp-json\/wp\/v2\/categories?post=61610"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wpcalc.com\/en\/wp-json\/wp\/v2\/tags?post=61610"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}