{"id":2959,"date":"2026-10-20T13:28:54","date_gmt":"2026-10-20T12:28:54","guid":{"rendered":"https:\/\/wpcalc.com\/pt\/medicos\/calculadora-mme-equivalentes-morfina\/"},"modified":"2026-10-20T13:28:54","modified_gmt":"2026-10-20T12:28:54","slug":"calculadora-mme-equivalentes-morfina","status":"publish","type":"post","link":"https:\/\/wpcalc.com\/pt\/medicos\/calculadora-mme-equivalentes-morfina\/","title":{"rendered":"Calculadora de MME \u2013 miligramas equivalentes de morfina"},"content":{"rendered":"<section class=\"not-prose calculator-box\" aria-labelledby=\"calculator-title\"><div class=\"flex items-baseline sm:items-center justify-between gap-2 sm:gap-3\"><div class=\"flex flex-col sm:flex-row sm:items-center gap-2\"><span class=\"icon icon-calculator text-primary-700! text-base! dark:text-primary-300!\" aria-hidden=\"true\"><\/span><h2 id=\"calculator-title\" class=\"text-lg font-display font-bold\">Some a dose di\u00e1ria total de opioides de um paciente em equivalentes de morfina<\/h2><\/div><div class=\"calcdash-favorite group\">\n  <button type=\"button\" class=\"favorite\" id=\"favorite\" data-favorite-id=\"2959\" data-favorite-title=\"MME\" data-favorite-url=\"https:\/\/wpcalc.com\/pt\/medicos\/calculadora-mme-equivalentes-morfina\/\" data-favorite-excerpt=\"Some rapidamente a dose di\u00e1ria total de opioides de um paciente em miligramas equivalentes de morfina (MME\/dia) usando os fatores de convers\u00e3o do CDC 2022. Insira at\u00e9 6 medicamentos, com dosagem, unidades por dose e doses por dia, para obter o total, o detalhamento por medicamento e as orienta\u00e7\u00f5es sobre os limiares do CDC.\" aria-label=\"Adicionar aos favoritos\" data-favorite-icon=\"icon icon-pharmacology\">\n    <span class=\"icon icon-shape-star-empty\" aria-hidden=\"true\"><\/span>\n  <\/button>\n  <div class=\"calcdash-favorite__tip\" aria-hidden=\"true\">\n   <span class=\"favorite-tooltip\" id=\"favorite-tooltip\"><\/span>\n  <\/div>\n  <span class=\"sr-only\" role=\"status\" id=\"favorite-status\"><\/span>\n<\/div><\/div><form action=\"https:\/\/wpcalc.com\/pt\/medicos\/calculadora-mme-equivalentes-morfina\/\" method=\"POST\" class=\"calculator\" id=\"calculator-2959\" data-post=\"2959\"><fieldset class=\"fieldset-input is-2\"><legend class=\"sr-only\">Campos de entrada<\/legend><div class=\"field is-single\" id=\"input-1\"><label for=\"field-1\">N\u00famero de medicamentos opioides<\/label><div class=\"grid grid-cols-1\"><select id=\"field-1\" name=\"nmero_de_medicamentos_opioides\"><option value=\"1\">1 medicamento<\/option><option value=\"2\" selected>2 medicamentos<\/option><option value=\"3\">3 medicamentos<\/option><option value=\"4\">4 medicamentos<\/option><option value=\"5\">5 medicamentos<\/option><option value=\"6\">6 medicamentos<\/option><\/select><svg class=\"pointer-events-none col-start-1 row-start-1 mr-2 size-5 self-center justify-self-end text-gray-500 sm:size-4\" viewBox=\"0 0 16 16\" fill=\"currentColor\" aria-hidden=\"true\" data-slot=\"icon\">\n              <path fill-rule=\"evenodd\" d=\"M4.22 6.22a.75.75 0 0 1 1.06 0L8 8.94l2.72-2.72a.75.75 0 1 1 1.06 1.06l-3.25 3.25a.75.75 0 0 1-1.06 0L4.22 7.28a.75.75 0 0 1 0-1.06Z\" clip-rule=\"evenodd\" \/>\n            <\/svg><\/div><\/div><div class=\"is-single field\" id=\"input-2\"><span class=\"font-semibold\">Medicamento 1<\/span><\/div><div class=\"field is-single\" id=\"input-3\"><label for=\"field-3\">Opioide<\/label><div class=\"grid grid-cols-1\"><select id=\"field-3\" name=\"opioide\"><option value=\"codeine\">Code\u00edna (0,15)<\/option><option value=\"fentanyl\">Adesivo transd\u00e9rmico de fentanil, mcg\/h (2,4)<\/option><option value=\"hydrocodone\">Hidrocodona (1)<\/option><option value=\"hydromorphone\">Hidromorfona (5)<\/option><option value=\"methadone\">Metadona (4,7)<\/option><option value=\"morphine\">Morfina (1)<\/option><option value=\"oxycodone\" selected>Oxicodona (1,5)<\/option><option value=\"oxymorphone\">Oximorfona (3)<\/option><option value=\"tapentadol\">Tapentadol (0,4)<\/option><option value=\"tramadol\">Tramadol (0,2)<\/option><\/select><svg class=\"pointer-events-none col-start-1 row-start-1 mr-2 size-5 self-center justify-self-end text-gray-500 sm:size-4\" viewBox=\"0 0 16 16\" fill=\"currentColor\" aria-hidden=\"true\" data-slot=\"icon\">\n              <path fill-rule=\"evenodd\" d=\"M4.22 6.22a.75.75 0 0 1 1.06 0L8 8.94l2.72-2.72a.75.75 0 1 1 1.06 1.06l-3.25 3.25a.75.75 0 0 1-1.06 0L4.22 7.28a.75.75 0 0 1 0-1.06Z\" clip-rule=\"evenodd\" \/>\n            <\/svg><\/div><\/div><div class=\"field has-term\" id=\"input-4\"><label for=\"field-4\">Concentra\u00e7\u00e3o por unidade<\/label><div class=\"term\">mg<\/div>  <div class=\"absolute bottom-0 left-16 top-8 w-2 h-0.5 bg-blue-500\"><\/div><input type=\"text\" name=\"concentrao_por_unidade\" id=\"field-4\" aria-describedby=\"calc-info-4\" data-number inputmode=\"decimal\" autocomplete=\"off\" spellcheck=\"false\" min=\"0\" value=\"5\"\/><small id=\"calc-info-4\">mg por comprimido, c\u00e1psula ou mL \u2014 para o adesivo de fentanil, informe mcg\/h.<\/small><\/div><div class=\"field\" id=\"input-5\"><label for=\"field-5\">Unidades por dose<\/label><input type=\"text\" name=\"unidades_por_dose\" id=\"field-5\" aria-describedby=\"calc-info-5\" data-number inputmode=\"decimal\" autocomplete=\"off\" spellcheck=\"false\" min=\"0\" value=\"1\"\/><small id=\"calc-info-5\">Comprimidos, c\u00e1psulas ou mL tomados de uma vez.<\/small><\/div><div class=\"field\" id=\"input-6\"><label for=\"field-6\">Doses por dia<\/label><input type=\"text\" name=\"doses_por_dia\" id=\"field-6\" data-number inputmode=\"decimal\" autocomplete=\"off\" spellcheck=\"false\" min=\"0\" value=\"4\"\/><\/div><div class=\"is-single field\" id=\"input-7\"><span class=\"font-semibold\">Medicamento 2<\/span><\/div><div class=\"field is-single\" id=\"input-8\"><label for=\"field-8\">Opioide<\/label><div class=\"grid grid-cols-1\"><select id=\"field-8\" name=\"opioide\"><option value=\"codeine\">Code\u00edna (0,15)<\/option><option value=\"fentanyl\">Adesivo transd\u00e9rmico de fentanil, mcg\/h (2,4)<\/option><option value=\"hydrocodone\">Hidrocodona (1)<\/option><option value=\"hydromorphone\">Hidromorfona (5)<\/option><option value=\"methadone\">Metadona (4,7)<\/option><option value=\"morphine\">Morfina (1)<\/option><option value=\"oxycodone\">Oxicodona (1,5)<\/option><option value=\"oxymorphone\">Oximorfona (3)<\/option><option value=\"tapentadol\">Tapentadol (0,4)<\/option><option value=\"tramadol\" selected>Tramadol (0,2)<\/option><\/select><svg class=\"pointer-events-none col-start-1 row-start-1 mr-2 size-5 self-center justify-self-end text-gray-500 sm:size-4\" viewBox=\"0 0 16 16\" fill=\"currentColor\" aria-hidden=\"true\" data-slot=\"icon\">\n              <path fill-rule=\"evenodd\" d=\"M4.22 6.22a.75.75 0 0 1 1.06 0L8 8.94l2.72-2.72a.75.75 0 1 1 1.06 1.06l-3.25 3.25a.75.75 0 0 1-1.06 0L4.22 7.28a.75.75 0 0 1 0-1.06Z\" clip-rule=\"evenodd\" \/>\n            <\/svg><\/div><\/div><div class=\"field has-term\" id=\"input-9\"><label for=\"field-9\">Concentra\u00e7\u00e3o por unidade<\/label><div class=\"term\">mg<\/div>  <div class=\"absolute bottom-0 left-16 top-8 w-2 h-0.5 bg-blue-500\"><\/div><input type=\"text\" name=\"concentrao_por_unidade\" id=\"field-9\" aria-describedby=\"calc-info-9\" data-number inputmode=\"decimal\" autocomplete=\"off\" spellcheck=\"false\" min=\"0\" value=\"50\"\/><small id=\"calc-info-9\">mg por comprimido, c\u00e1psula ou mL \u2014 para o adesivo de fentanil, informe mcg\/h.<\/small><\/div><div class=\"field\" id=\"input-10\"><label for=\"field-10\">Unidades por dose<\/label><input type=\"text\" name=\"unidades_por_dose\" id=\"field-10\" aria-describedby=\"calc-info-10\" data-number inputmode=\"decimal\" autocomplete=\"off\" spellcheck=\"false\" min=\"0\" value=\"1\"\/><small id=\"calc-info-10\">Comprimidos, c\u00e1psulas ou mL tomados de uma vez.<\/small><\/div><div class=\"field\" id=\"input-11\"><label for=\"field-11\">Doses por dia<\/label><input type=\"text\" name=\"doses_por_dia\" id=\"field-11\" data-number inputmode=\"decimal\" autocomplete=\"off\" spellcheck=\"false\" min=\"0\" value=\"3\"\/><\/div><div class=\"is-single field\" id=\"input-12\" hidden><span class=\"font-semibold\">Medicamento 3<\/span><\/div><div class=\"field is-single\" id=\"input-13\" hidden><label for=\"field-13\">Opioide<\/label><div class=\"grid grid-cols-1\"><select id=\"field-13\" name=\"opioide\"><option value=\"codeine\">Code\u00edna (0,15)<\/option><option value=\"fentanyl\">Adesivo transd\u00e9rmico de fentanil, mcg\/h (2,4)<\/option><option value=\"hydrocodone\">Hidrocodona (1)<\/option><option value=\"hydromorphone\">Hidromorfona (5)<\/option><option value=\"methadone\">Metadona (4,7)<\/option><option value=\"morphine\" selected>Morfina (1)<\/option><option value=\"oxycodone\">Oxicodona (1,5)<\/option><option value=\"oxymorphone\">Oximorfona (3)<\/option><option value=\"tapentadol\">Tapentadol (0,4)<\/option><option value=\"tramadol\">Tramadol (0,2)<\/option><\/select><svg class=\"pointer-events-none col-start-1 row-start-1 mr-2 size-5 self-center justify-self-end text-gray-500 sm:size-4\" viewBox=\"0 0 16 16\" fill=\"currentColor\" aria-hidden=\"true\" data-slot=\"icon\">\n              <path fill-rule=\"evenodd\" d=\"M4.22 6.22a.75.75 0 0 1 1.06 0L8 8.94l2.72-2.72a.75.75 0 1 1 1.06 1.06l-3.25 3.25a.75.75 0 0 1-1.06 0L4.22 7.28a.75.75 0 0 1 0-1.06Z\" clip-rule=\"evenodd\" \/>\n            <\/svg><\/div><\/div><div class=\"field has-term\" id=\"input-14\" hidden><label for=\"field-14\">Concentra\u00e7\u00e3o por unidade<\/label><div class=\"term\">mg<\/div>  <div class=\"absolute bottom-0 left-16 top-8 w-2 h-0.5 bg-blue-500\"><\/div><input type=\"text\" name=\"concentrao_por_unidade\" id=\"field-14\" data-number inputmode=\"decimal\" autocomplete=\"off\" spellcheck=\"false\" min=\"0\" value=\"0\"\/><\/div><div class=\"field\" id=\"input-15\" hidden><label for=\"field-15\">Unidades por dose<\/label><input type=\"text\" name=\"unidades_por_dose\" id=\"field-15\" data-number inputmode=\"decimal\" autocomplete=\"off\" spellcheck=\"false\" min=\"0\" value=\"1\"\/><\/div><div class=\"field\" id=\"input-16\" hidden><label for=\"field-16\">Doses por dia<\/label><input type=\"text\" name=\"doses_por_dia\" id=\"field-16\" data-number inputmode=\"decimal\" autocomplete=\"off\" spellcheck=\"false\" min=\"0\" value=\"1\"\/><\/div><div class=\"is-single field\" id=\"input-17\" hidden><span class=\"font-semibold\">Medicamento 4<\/span><\/div><div class=\"field is-single\" id=\"input-18\" hidden><label for=\"field-18\">Opioide<\/label><div class=\"grid grid-cols-1\"><select id=\"field-18\" name=\"opioide\"><option value=\"codeine\">Code\u00edna (0,15)<\/option><option value=\"fentanyl\">Adesivo transd\u00e9rmico de fentanil, mcg\/h (2,4)<\/option><option value=\"hydrocodone\">Hidrocodona (1)<\/option><option value=\"hydromorphone\">Hidromorfona (5)<\/option><option value=\"methadone\">Metadona (4,7)<\/option><option value=\"morphine\" selected>Morfina (1)<\/option><option value=\"oxycodone\">Oxicodona (1,5)<\/option><option value=\"oxymorphone\">Oximorfona (3)<\/option><option value=\"tapentadol\">Tapentadol (0,4)<\/option><option value=\"tramadol\">Tramadol (0,2)<\/option><\/select><svg class=\"pointer-events-none col-start-1 row-start-1 mr-2 size-5 self-center justify-self-end text-gray-500 sm:size-4\" viewBox=\"0 0 16 16\" fill=\"currentColor\" aria-hidden=\"true\" data-slot=\"icon\">\n              <path fill-rule=\"evenodd\" d=\"M4.22 6.22a.75.75 0 0 1 1.06 0L8 8.94l2.72-2.72a.75.75 0 1 1 1.06 1.06l-3.25 3.25a.75.75 0 0 1-1.06 0L4.22 7.28a.75.75 0 0 1 0-1.06Z\" clip-rule=\"evenodd\" \/>\n            <\/svg><\/div><\/div><div class=\"field has-term\" id=\"input-19\" hidden><label for=\"field-19\">Concentra\u00e7\u00e3o por unidade<\/label><div class=\"term\">mg<\/div>  <div class=\"absolute bottom-0 left-16 top-8 w-2 h-0.5 bg-blue-500\"><\/div><input type=\"text\" name=\"concentrao_por_unidade\" id=\"field-19\" data-number inputmode=\"decimal\" autocomplete=\"off\" spellcheck=\"false\" min=\"0\" value=\"0\"\/><\/div><div class=\"field\" id=\"input-20\" hidden><label for=\"field-20\">Unidades por dose<\/label><input type=\"text\" name=\"unidades_por_dose\" id=\"field-20\" data-number inputmode=\"decimal\" autocomplete=\"off\" spellcheck=\"false\" min=\"0\" value=\"1\"\/><\/div><div class=\"field\" id=\"input-21\" hidden><label for=\"field-21\">Doses por dia<\/label><input type=\"text\" name=\"doses_por_dia\" id=\"field-21\" data-number inputmode=\"decimal\" autocomplete=\"off\" spellcheck=\"false\" min=\"0\" value=\"1\"\/><\/div><div class=\"is-single field\" id=\"input-22\" hidden><span class=\"font-semibold\">Medicamento 5<\/span><\/div><div class=\"field is-single\" id=\"input-23\" hidden><label for=\"field-23\">Opioide<\/label><div class=\"grid grid-cols-1\"><select id=\"field-23\" name=\"opioide\"><option value=\"codeine\">Code\u00edna (0,15)<\/option><option value=\"fentanyl\">Adesivo transd\u00e9rmico de fentanil, mcg\/h (2,4)<\/option><option value=\"hydrocodone\">Hidrocodona (1)<\/option><option value=\"hydromorphone\">Hidromorfona (5)<\/option><option value=\"methadone\">Metadona (4,7)<\/option><option value=\"morphine\" selected>Morfina (1)<\/option><option value=\"oxycodone\">Oxicodona (1,5)<\/option><option value=\"oxymorphone\">Oximorfona (3)<\/option><option value=\"tapentadol\">Tapentadol (0,4)<\/option><option value=\"tramadol\">Tramadol (0,2)<\/option><\/select><svg class=\"pointer-events-none col-start-1 row-start-1 mr-2 size-5 self-center justify-self-end text-gray-500 sm:size-4\" viewBox=\"0 0 16 16\" fill=\"currentColor\" aria-hidden=\"true\" data-slot=\"icon\">\n              <path fill-rule=\"evenodd\" d=\"M4.22 6.22a.75.75 0 0 1 1.06 0L8 8.94l2.72-2.72a.75.75 0 1 1 1.06 1.06l-3.25 3.25a.75.75 0 0 1-1.06 0L4.22 7.28a.75.75 0 0 1 0-1.06Z\" clip-rule=\"evenodd\" \/>\n            <\/svg><\/div><\/div><div class=\"field has-term\" id=\"input-24\" hidden><label for=\"field-24\">Concentra\u00e7\u00e3o por unidade<\/label><div class=\"term\">mg<\/div>  <div class=\"absolute bottom-0 left-16 top-8 w-2 h-0.5 bg-blue-500\"><\/div><input type=\"text\" name=\"concentrao_por_unidade\" id=\"field-24\" data-number inputmode=\"decimal\" autocomplete=\"off\" spellcheck=\"false\" min=\"0\" value=\"0\"\/><\/div><div class=\"field\" id=\"input-25\" hidden><label for=\"field-25\">Unidades por dose<\/label><input type=\"text\" name=\"unidades_por_dose\" id=\"field-25\" data-number inputmode=\"decimal\" autocomplete=\"off\" spellcheck=\"false\" min=\"0\" value=\"1\"\/><\/div><div class=\"field\" id=\"input-26\" hidden><label for=\"field-26\">Doses por dia<\/label><input type=\"text\" name=\"doses_por_dia\" id=\"field-26\" data-number inputmode=\"decimal\" autocomplete=\"off\" spellcheck=\"false\" min=\"0\" value=\"1\"\/><\/div><div class=\"is-single field\" id=\"input-27\" hidden><span class=\"font-semibold\">Medicamento 6<\/span><\/div><div class=\"field is-single\" id=\"input-28\" hidden><label for=\"field-28\">Opioide<\/label><div class=\"grid grid-cols-1\"><select id=\"field-28\" name=\"opioide\"><option value=\"codeine\">Code\u00edna (0,15)<\/option><option value=\"fentanyl\">Adesivo transd\u00e9rmico de fentanil, mcg\/h (2,4)<\/option><option value=\"hydrocodone\">Hidrocodona (1)<\/option><option value=\"hydromorphone\">Hidromorfona (5)<\/option><option value=\"methadone\">Metadona (4,7)<\/option><option value=\"morphine\" selected>Morfina (1)<\/option><option value=\"oxycodone\">Oxicodona (1,5)<\/option><option value=\"oxymorphone\">Oximorfona (3)<\/option><option value=\"tapentadol\">Tapentadol (0,4)<\/option><option value=\"tramadol\">Tramadol (0,2)<\/option><\/select><svg class=\"pointer-events-none col-start-1 row-start-1 mr-2 size-5 self-center justify-self-end text-gray-500 sm:size-4\" viewBox=\"0 0 16 16\" fill=\"currentColor\" aria-hidden=\"true\" data-slot=\"icon\">\n              <path fill-rule=\"evenodd\" d=\"M4.22 6.22a.75.75 0 0 1 1.06 0L8 8.94l2.72-2.72a.75.75 0 1 1 1.06 1.06l-3.25 3.25a.75.75 0 0 1-1.06 0L4.22 7.28a.75.75 0 0 1 0-1.06Z\" clip-rule=\"evenodd\" \/>\n            <\/svg><\/div><\/div><div class=\"field has-term\" id=\"input-29\" hidden><label for=\"field-29\">Concentra\u00e7\u00e3o por unidade<\/label><div class=\"term\">mg<\/div>  <div class=\"absolute bottom-0 left-16 top-8 w-2 h-0.5 bg-blue-500\"><\/div><input type=\"text\" name=\"concentrao_por_unidade\" id=\"field-29\" data-number inputmode=\"decimal\" autocomplete=\"off\" spellcheck=\"false\" min=\"0\" value=\"0\"\/><\/div><div class=\"field\" id=\"input-30\" hidden><label for=\"field-30\">Unidades por dose<\/label><input type=\"text\" name=\"unidades_por_dose\" id=\"field-30\" data-number inputmode=\"decimal\" autocomplete=\"off\" spellcheck=\"false\" min=\"0\" value=\"1\"\/><\/div><div class=\"field\" id=\"input-31\" hidden><label for=\"field-31\">Doses por dia<\/label><input type=\"text\" name=\"doses_por_dia\" id=\"field-31\" data-number inputmode=\"decimal\" autocomplete=\"off\" spellcheck=\"false\" min=\"0\" value=\"1\"\/><\/div><\/fieldset><div class=\"buttons\"><button type=\"submit\" data-text=\"Recalcular\" id=\"calculate-button\" data-post=\"2959\">Calcular<\/button><button type=\"reset\">Redefinir<\/button><\/div><div class=\"field is-checkbox hidden!\" id=\"field-auto-calc\"><input type=\"checkbox\" id=\"auto-calc\"><label for=\"auto-calc\">Calcular automaticamente<\/label><small>Se ativado, o resultado \u00e9 atualizado automaticamente quando voc\u00ea altera qualquer valor.<\/small><\/div><div class=\"fieldset-result is-hidden\" aria-labelledby=\"result-title\" aria-live=\"polite\" role=\"region\"> <h3 class=\"result-title bg-gradient-to-r from-primary-50 to-gray-50 dark:from-primary-900 dark:to-gray-800\" id=\"result-title\"><span class=\"icon icon-s-pulse\" aria-hidden=\"true\"><\/span> MME di\u00e1rio total<\/h3><div class=\"result-box\"><div class=\"field-result\" id=\"output-1\"><span class=\"field-title\"><span>MME di\u00e1rio total<\/span><\/span><span class=\"field-value\" id=\"result-1\" data-unit=\"MME\/dia\"><\/span><button type=\"button\" class=\"copy-result\" data-tooltip=\"Copiar resultado\" aria-label=\"Copiar resultado\"><span class=\"copy-icon icon icon-document-copy\" aria-hidden=\"true\"><\/span><\/button><\/div><div class=\"field-result\" id=\"output-2\"><span class=\"field-title\"><span>MME do medicamento 1<\/span><\/span><span class=\"field-value\" id=\"result-2\" data-unit=\"MME\/dia\"><\/span><button type=\"button\" class=\"copy-result\" data-tooltip=\"Copiar resultado\" aria-label=\"Copiar resultado\"><span class=\"copy-icon icon icon-document-copy\" aria-hidden=\"true\"><\/span><\/button><\/div><div class=\"field-result\" id=\"output-3\"><span class=\"field-title\"><span>MME do medicamento 2<\/span><\/span><span class=\"field-value\" id=\"result-3\" data-unit=\"MME\/dia\"><\/span><button type=\"button\" class=\"copy-result\" data-tooltip=\"Copiar resultado\" aria-label=\"Copiar resultado\"><span class=\"copy-icon icon icon-document-copy\" aria-hidden=\"true\"><\/span><\/button><\/div><div class=\"field-result\" id=\"output-4\"><span class=\"field-title\"><span>MME do medicamento 3<\/span><\/span><span class=\"field-value\" id=\"result-4\" data-unit=\"MME\/dia\"><\/span><button type=\"button\" class=\"copy-result\" data-tooltip=\"Copiar resultado\" aria-label=\"Copiar resultado\"><span class=\"copy-icon icon icon-document-copy\" aria-hidden=\"true\"><\/span><\/button><\/div><div class=\"field-result\" id=\"output-5\"><span class=\"field-title\"><span>MME do medicamento 4<\/span><\/span><span class=\"field-value\" id=\"result-5\" data-unit=\"MME\/dia\"><\/span><button type=\"button\" class=\"copy-result\" data-tooltip=\"Copiar resultado\" aria-label=\"Copiar resultado\"><span class=\"copy-icon icon icon-document-copy\" aria-hidden=\"true\"><\/span><\/button><\/div><div class=\"field-result\" id=\"output-6\"><span class=\"field-title\"><span>MME do medicamento 5<\/span><\/span><span class=\"field-value\" id=\"result-6\" data-unit=\"MME\/dia\"><\/span><button type=\"button\" class=\"copy-result\" data-tooltip=\"Copiar resultado\" aria-label=\"Copiar resultado\"><span class=\"copy-icon icon icon-document-copy\" aria-hidden=\"true\"><\/span><\/button><\/div><div class=\"field-result\" id=\"output-7\"><span class=\"field-title\"><span>MME do medicamento 6<\/span><\/span><span class=\"field-value\" id=\"result-7\" data-unit=\"MME\/dia\"><\/span><button type=\"button\" class=\"copy-result\" data-tooltip=\"Copiar resultado\" aria-label=\"Copiar resultado\"><span class=\"copy-icon icon icon-document-copy\" aria-hidden=\"true\"><\/span><\/button><\/div><div class=\"field-result is-column\" id=\"output-8\"><span class=\"field-title\"><span>Detalhamento por medicamento<\/span><\/span><span class=\"field-value\" id=\"result-8\"><\/span><button type=\"button\" class=\"copy-result\" data-tooltip=\"Copiar resultado\" aria-label=\"Copiar resultado\"><span class=\"copy-icon icon icon-document-copy\" aria-hidden=\"true\"><\/span><\/button><\/div><div class=\"field-result is-column\" id=\"output-9\"><span class=\"field-title\"><span>Orienta\u00e7\u00f5es sobre limites de dose (CDC 2022)<\/span><\/span><span class=\"field-value\" id=\"result-9\"><\/span><button type=\"button\" class=\"copy-result\" data-tooltip=\"Copiar resultado\" aria-label=\"Copiar resultado\"><span class=\"copy-icon icon icon-document-copy\" aria-hidden=\"true\"><\/span><\/button><\/div><div class=\"field-result is-column\" id=\"output-10\"><span class=\"field-title\"><span>Observa\u00e7\u00f5es importantes para profissionais de sa\u00fade<\/span><\/span><span class=\"field-value\" id=\"result-10\"><\/span><button type=\"button\" class=\"copy-result\" data-tooltip=\"Copiar resultado\" aria-label=\"Copiar resultado\"><span class=\"copy-icon icon icon-document-copy\" aria-hidden=\"true\"><\/span><\/button><\/div><\/div><div class=\"result-actions\"><button type=\"button\" class=\"copy-link\"><svg viewBox=\"0 0 20 20\" fill=\"currentColor\" aria-hidden=\"true\"><path d=\"M12.232 4.232a2.5 2.5 0 0 1 3.536 3.536l-1.225 1.224a.75.75 0 0 0 1.061 1.06l1.224-1.224a4 4 0 0 0-5.656-5.656l-3 3a4 4 0 0 0 .225 5.865.75.75 0 0 0 .977-1.138 2.5 2.5 0 0 1-.142-3.667l3-3Z\"\/><path d=\"M11.603 7.963a.75.75 0 0 0-.977 1.138 2.5 2.5 0 0 1 .142 3.667l-3 3a2.5 2.5 0 0 1-3.536-3.536l1.225-1.224a.75.75 0 0 0-1.061-1.06l-1.224 1.224a4 4 0 1 0 5.656 5.656l3-3a4 4 0 0 0-.225-5.865Z\"\/><\/svg><span class=\"copy-link__text\">Copiar link para este c\u00e1lculo<\/span><\/button><span class=\"sr-only\" role=\"status\" id=\"copy-link-status\"><\/span><\/div><\/div><a href=\"#respond\" class=\"hidden transition-opacity duration-300 opacity-0 w-50 text-sm justify-center items-center gap-2 px-4 py-2 rounded bg-gray-200 text-gray-700 hover:bg-gray-300\" id=\"leave-comment\"><span class=\"icon icon-comments\" aria-hidden=\"true\"><\/span>Deixar um coment\u00e1rio<\/a><\/form><\/section><section id=\"calc-reactions\" class=\"not-prose hidden my-12 bg-gradient-to-r from-primary-50 to-gray-50 border border-indigo-100 rounded-xl px-6 py-4 shadow-sm\" data-post=\"2959\" aria-live=\"polite\" aria-labelledby=\"calc-reactions-title\"><p id=\"calc-reactions-title\" class=\"text-sm text-gray-500 text-center mb-2\">O que voc\u00ea achou deste resultado?<\/p><div role=\"group\" aria-labelledby=\"calc-reactions-title\" class=\"grid grid-cols-3 sm:flex sm:flex-row sm:justify-around gap-4 sm:items-center sm:flex-wrap\"><button type=\"button\" aria-pressed=\"false\" class=\"reaction-btn flex flex-col items-center gap-1 text-sm text-gray-700 hover:text-primary-600 cursor-pointer transition-transform hover:scale-105\" data-reaction=\"like\"><span class=\"reaction-count\" data-reaction-count=\"like\">0<\/span><span class=\"reaction text-3xl\" aria-hidden=\"true\">\ud83d\ude00 <\/span><span class=\"reaction-description font-medium\">Curti <\/span><\/button><button type=\"button\" aria-pressed=\"false\" class=\"reaction-btn flex flex-col items-center gap-1 text-sm text-gray-700 hover:text-primary-600 cursor-pointer transition-transform hover:scale-105\" data-reaction=\"helpful\"><span class=\"reaction-count\" data-reaction-count=\"helpful\">0<\/span><span class=\"reaction text-3xl\" aria-hidden=\"true\">\ud83d\udca1 <\/span><span class=\"reaction-description font-medium\">\u00datil <\/span><\/button><button type=\"button\" aria-pressed=\"false\" class=\"reaction-btn flex flex-col items-center gap-1 text-sm text-gray-700 hover:text-primary-600 cursor-pointer transition-transform hover:scale-105\" data-reaction=\"confused\"><span class=\"reaction-count\" data-reaction-count=\"confused\">0<\/span><span class=\"reaction text-3xl\" aria-hidden=\"true\">\ud83d\ude15 <\/span><span class=\"reaction-description font-medium\">Confuso <\/span><\/button><button type=\"button\" aria-pressed=\"false\" class=\"reaction-btn flex flex-col items-center gap-1 text-sm text-gray-700 hover:text-primary-600 cursor-pointer transition-transform hover:scale-105\" data-reaction=\"disappointed\"><span class=\"reaction-count\" data-reaction-count=\"disappointed\">0<\/span><span class=\"reaction text-3xl\" aria-hidden=\"true\">\ud83d\ude1e <\/span><span class=\"reaction-description font-medium\">Decepcionado <\/span><\/button><button type=\"button\" aria-pressed=\"false\" class=\"reaction-btn flex flex-col items-center gap-1 text-sm text-gray-700 hover:text-primary-600 cursor-pointer transition-transform hover:scale-105\" data-reaction=\"inaccurate\"><span class=\"reaction-count\" data-reaction-count=\"inaccurate\">0<\/span><span class=\"reaction text-3xl\" aria-hidden=\"true\">\u274c <\/span><span class=\"reaction-description font-medium\">Impreciso <\/span><\/button><\/div><div id=\"reaction-message\" class=\"hidden mt-8 rounded-md border border-primary-100 bg-white\/50 backdrop-blur-sm px-4 py-2 text-sm text-center shadow-sm\"><\/div><\/section><div class=\"calcdash-ad not-prose calcdash-ad--calc_result calcdash-ad--in-article\"><ins class=\"adsbygoogle\" style=\"display:block\" data-ad-client=\"ca-pub-1721569815777345\" data-ad-slot=\"6317458308\" data-ad-layout=\"in-article\" data-ad-format=\"fluid\"><\/ins><script>(adsbygoogle = window.adsbygoogle || []).push({});<\/script><\/div>\n<style id=\"wpcoderpro-inline-1\">.formula-box {\r\n\tborder-bottom: none !important;\r\n}<\/style><section class=\"formula-box\" aria-labelledby=\"formula-title\">\r\n\t<div id=\"formula-title\" class=\"not-prose font-display mb-4\"><span class=\"icon icon-formula\" aria-hidden=\"true\"><\/span><h2>F\u00f3rmula do MME<\/h2><\/div>\r\n\t<figure class=\"not-prose formula\">\r\n\t\t<figcaption class=\"formula-title\">F\u00f3rmula<\/figcaption>\r\n\t\t<div class=\"text-base text-gray-800\" id=\"formula\">\n\\[ \\text{MME\/dia de um opioide} = S \\times U \\times D \\times F \\\\ \\text{MME total di\u00e1rio} = \\sum_{i=1}^{n} S_i \\times U_i \\times D_i \\times F_i \\\\ \\text{Adesivo transd\u00e9rmico de fentanila: } \\text{MME\/dia} = \\text{mcg\/h} \\times 2.4 \\]\n<\/div>\r\n\t<\/figure>\r\n\t<\/p>\n<p><strong>Em que:<\/strong><\/p>\n<ul>\n<li>\\(S\\) \u2014 dosagem por unidade: miligramas por comprimido, c\u00e1psula ou mL<\/li>\n<li>\\(U\\) \u2014 unidades por dose, ou seja, quantos comprimidos ou c\u00e1psulas s\u00e3o tomados de uma s\u00f3 vez<\/li>\n<li>\\(D\\) \u2014 doses tomadas por dia<\/li>\n<li>\\(F\\) \u2014 fator de convers\u00e3o do CDC 2022 para equivalentes de morfina (ex.: oxicodona 1,5, tramadol 0,2)<\/li>\n<li>\\(n\\) \u2014 n\u00famero de medicamentos opioides que o paciente toma (de 1 a 6)<\/li>\n<\/ul>\n<p>A f\u00f3rmula converte a quantidade di\u00e1ria total de cada opioide para o seu equivalente em miligramas de morfina, usando os fatores de convers\u00e3o do CDC 2022, e depois soma tudo para expressar a carga di\u00e1ria combinada de opioides em um \u00fanico n\u00famero.<\/p>\n<p>\r\n<\/section>\n<style id=\"wpcoderpro-inline-2\">.calculation-box {\r\n\tborder-bottom: none !important;\r\n}<\/style><section id=\"calculation\" class=\"calculation-box\" aria-labelledby=\"calculation-title\">\r\n\t<div id=\"calculation-title\" class=\"not-prose font-display\"><span class=\"icon icon-unordered-list\" aria-hidden=\"true\"><\/span><h2>MME \u2013 Exemplo de c\u00e1lculo<\/h2><\/div>\r\n\r\n<\/p>\n<p><strong>Exemplo:<\/strong> um paciente toma comprimidos de oxicodona 5 mg, um comprimido quatro vezes ao dia, e c\u00e1psulas de tramadol 50 mg, uma c\u00e1psula tr\u00eas vezes ao dia. Esses s\u00e3o os valores padr\u00e3o da calculadora.<\/p>\n<p>\\[ \\text{Oxicodona: } 5 \\times 1 \\times 4 \\times 1.5 = 30 \\text{ MME\/dia} \\]<\/p>\n<p>\\[ \\text{Tramadol: } 50 \\times 1 \\times 3 \\times 0.2 = 30 \\text{ MME\/dia} \\]<\/p>\n<p>\\[ \\text{Total: } 30 + 30 = 60 \\text{ MME\/dia} \\]<\/p>\n<p><strong>Resultado:<\/strong> 60 MME\/dia \u2014 30 vindos da oxicodona e 30 do tramadol. Como o total est\u00e1 em 50 MME\/dia ou acima, o CDC recomenda reavaliar benef\u00edcios e riscos, considerar a redu\u00e7\u00e3o da dose e adotar precau\u00e7\u00f5es adicionais.<\/p>\n<p>\n\r\n<\/section>\n<h2>Como usar a calculadora de MME<\/h2>\n<ol>\n<li>Defina o <strong>n\u00famero de medicamentos opioides<\/strong> de acordo com o esquema do paciente (de 1 a 6). As linhas de entrada de cada medicamento extra aparecem automaticamente.<\/li>\n<li>Para cada medicamento, escolha o opioide na lista suspensa <strong>Opioide<\/strong> \u2014 o fator de convers\u00e3o do CDC 2022 aparece entre par\u00eanteses ao lado de cada op\u00e7\u00e3o.<\/li>\n<li>Informe a <strong>dosagem por unidade<\/strong>: miligramas por comprimido, c\u00e1psula ou mL. No caso do adesivo transd\u00e9rmico de fentanila, informe a taxa de libera\u00e7\u00e3o em mcg\/h.<\/li>\n<li>Informe as <strong>unidades por dose<\/strong> (ex.: 2 comprimidos) e as <strong>doses por dia<\/strong>. Esses dois campos ficam ocultos no caso do adesivo de fentanila, porque o adesivo libera o medicamento continuamente e apenas o valor em mcg\/h importa.<\/li>\n<li>Pressione o bot\u00e3o de c\u00e1lculo. Os resultados mostram o <strong>MME total di\u00e1rio<\/strong>, a contribui\u00e7\u00e3o de cada medicamento em MME\/dia, o detalhamento linha por linha das contas e as orienta\u00e7\u00f5es do CDC sobre os limiares para a dose resultante.<\/li>\n<li>Passe o cursor sobre os \u00edcones de interroga\u00e7\u00e3o ao lado dos campos para relembrar rapidamente o que cada um espera.<\/li>\n<\/ol>\n<h2>O que s\u00e3o miligramas equivalentes de morfina?<\/h2>\n<p>Miligramas equivalentes de morfina (MME) \u00e9 uma forma padr\u00e3o de expressar a quantidade total de opioides que um paciente toma por dia, convertida em uma dose equivalente de morfina oral. Um paciente com 60 MME\/dia recebe uma carga de opioides compar\u00e1vel a 60 mg de morfina oral por dia \u2014 independentemente de os medicamentos reais serem comprimidos, c\u00e1psulas, solu\u00e7\u00f5es ou adesivos, e independentemente de quantos opioides diferentes estejam envolvidos.<\/p>\n<p>O principal motivo pelo qual os profissionais calculam o MME \u00e9 o risco de overdose. A Diretriz de Pr\u00e1tica Cl\u00ednica de 2022 do CDC identificou dois pontos de decis\u00e3o: em <strong>50 MME\/dia<\/strong>, os benef\u00edcios devem ser cuidadosamente ponderados em rela\u00e7\u00e3o aos riscos, considerando redu\u00e7\u00e3o gradual ou diminui\u00e7\u00e3o da dose, monitoramento mais pr\u00f3ximo, oferta de naloxona e evitar o uso concomitante de benzodiazep\u00ednicos e \u00e1lcool. Em <strong>90 MME\/dia<\/strong>, o CDC recomenda evitar completamente essa faixa de dose, porque o risco de overdose aumenta substancialmente; manter tais doses exige justificativa documentada, reavalia\u00e7\u00f5es frequentes e, quando poss\u00edvel, participa\u00e7\u00e3o de especialistas.<\/p>\n<p>O MME tamb\u00e9m \u00e9 \u00fatil na pr\u00e1tica cotidiana para revelar cargas ocultas de opioides. Um paciente pode parecer estar tomando uma dose \"modesta\" de tramadol mais oxicodona, mas o MME combinado pode ultrapassar um limiar de seguran\u00e7a que nenhuma das duas prescri\u00e7\u00f5es isoladas indicaria. Farmac\u00eauticos tamb\u00e9m usam o MME ao consultar dados dos programas de monitoramento de prescri\u00e7\u00e3o de medicamentos controlados (PDMP) para verificar a exposi\u00e7\u00e3o cumulativa a opioides entre diferentes prescritores.<\/p>\n<p>Interpretar o resultado exige contexto: o MME mede a <em>carga<\/em> de opioides, e n\u00e3o o al\u00edvio da dor nem a quantidade de opioide que \u00e9 de fato absorvida. Alguns pacientes metabolizam mal a code\u00edna e o tramadol e sentem pouco efeito, enquanto outros s\u00e3o metabolizadores ultrarr\u00e1pidos. Dois pacientes com o mesmo MME podem ter situa\u00e7\u00f5es cl\u00ednicas muito diferentes, de modo que o n\u00famero apoia \u2014 mas nunca substitui \u2014 o julgamento cl\u00ednico. Se o paciente usa v\u00e1rios opioides, uma l\u00f3gica semelhante de verifica\u00e7\u00e3o de doses pode se aplicar a outros medicamentos; nossas <a href=\"https:\/\/wpcalc.com\/pt\/medicos\/dose-liquida-medicamento\/\">calculadoras de dose l\u00edquida de medicamentos<\/a> e <a href=\"https:\/\/wpcalc.com\/pt\/medicos\/dose-de-comprimidos\/\">de dose de comprimidos<\/a> podem ajudar a conferir as dosagens individuais das prescri\u00e7\u00f5es.<\/p>\n<h2>Fatores de convers\u00e3o utilizados (CDC 2022)<\/h2>\n<table>\n<thead>\n<tr>\n<th>Opioide<\/th>\n<th>Fator de convers\u00e3o<\/th>\n<th>MME por unidade do f\u00e1rmaco<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>Code\u00edna<\/td>\n<td>0,15<\/td>\n<td>1 mg = 0,15 MME<\/td>\n<\/tr>\n<tr>\n<td>Adesivo transd\u00e9rmico de fentanila<\/td>\n<td>2,4<\/td>\n<td>1 mcg\/h = 2,4 MME\/dia<\/td>\n<\/tr>\n<tr>\n<td>Hidrocodona<\/td>\n<td>1<\/td>\n<td>1 mg = 1 MME<\/td>\n<\/tr>\n<tr>\n<td>Hidromorfona<\/td>\n<td>5<\/td>\n<td>1 mg = 5 MME<\/td>\n<\/tr>\n<tr>\n<td>Metadona<\/td>\n<td>4,7<\/td>\n<td>1 mg = 4,7 MME<\/td>\n<\/tr>\n<tr>\n<td>Morfina<\/td>\n<td>1<\/td>\n<td>1 mg = 1 MME (refer\u00eancia)<\/td>\n<\/tr>\n<tr>\n<td>Oxicodona<\/td>\n<td>1,5<\/td>\n<td>1 mg = 1,5 MME<\/td>\n<\/tr>\n<tr>\n<td>Oximorfona<\/td>\n<td>3<\/td>\n<td>1 mg = 3 MME<\/td>\n<\/tr>\n<tr>\n<td>Tapentadol<\/td>\n<td>0,4<\/td>\n<td>1 mg = 0,4 MME<\/td>\n<\/tr>\n<tr>\n<td>Tramadol<\/td>\n<td>0,2<\/td>\n<td>1 mg = 0,2 MME<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>Limita\u00e7\u00f5es e dicas pr\u00e1ticas<\/h2>\n<ul>\n<li><strong>Nunca use os fatores de MME para converter ou trocar opioides.<\/strong> O CDC deixa claro que esses fatores servem apenas para estimar a carga total de opioides. Trocar diretamente um opioide por outro usando esses fatores pode causar subdose ou overdose graves.<\/li>\n<li><strong>A metadona n\u00e3o \u00e9 linear.<\/strong> Seu efeito analg\u00e9sico n\u00e3o cresce com a dose da forma que um \u00fanico fator sugere, e ela se acumula ao longo do tempo por causa da meia-vida longa \u2014 ajustes de dose de metadona devem ser sempre feitos por um cl\u00ednico experiente.<\/li>\n<li><strong>Os fatores de tramadol e tapentadol s\u00e3o aproxima\u00e7\u00f5es.<\/strong> A equival\u00eancia em MME desses f\u00e1rmacos depende do metabolismo, que varia entre pacientes.<\/li>\n<li><strong>A buprenorfina fica de fora<\/strong> porque a diretriz do CDC 2022 n\u00e3o traz fator de convers\u00e3o para ela.<\/li>\n<li><strong>Confira a prescri\u00e7\u00e3o real.<\/strong> Verifique a concentra\u00e7\u00e3o do produto, a quantidade de comprimidos ou c\u00e1psulas, a frequ\u00eancia de administra\u00e7\u00e3o e as orienta\u00e7\u00f5es antes de confiar no resultado \u2014 o uso impl\u00edcito \"se necess\u00e1rio\" pode diferir do que os pacientes realmente tomam.<\/li>\n<li><strong>Os valores de 50 e 90 MME\/dia s\u00e3o pontos de checagem preventivos, n\u00e3o limites absolutos.<\/strong> Algumas situa\u00e7\u00f5es cl\u00ednicas (dor oncol\u00f3gica, cuidados paliativos, tratamento de transtorno por uso de opioides) exigem considera\u00e7\u00f5es diferentes das da diretriz geral.<\/li>\n<li>Ao revisar um esquema complexo, um <a href=\"https:\/\/wpcalc.com\/pt\/medicos\/teste-rastreio-abuso-de-drogas-dast-20\/\">Teste de Triagem de Abuso de Drogas (DAST)<\/a> pode complementar o valor de MME na avalia\u00e7\u00e3o de risco, e a <a href=\"https:\/\/wpcalc.com\/pt\/medicos\/tempo-de-meia-vida-medicamento\/\">calculadora de meia-vida<\/a> ajuda a entender o ac\u00famulo com opioides de a\u00e7\u00e3o prolongada, como a metadona.<\/li>\n<\/ul>\n<p>Esta calculadora \u00e9 uma ferramenta de c\u00e1lculo para cl\u00ednicos e profissionais de farm\u00e1cia \u2014 n\u00e3o \u00e9 aconselhamento m\u00e9dico nem substitui a Diretriz de Pr\u00e1tica Cl\u00ednica completa do CDC 2022 ou a avalia\u00e7\u00e3o cl\u00ednica individual.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Some rapidamente a dose di\u00e1ria total de opioides de um paciente em miligramas equivalentes de morfina (MME\/dia) usando os fatores de convers\u00e3o do CDC 2022. Insira at\u00e9 6 medicamentos, com dosagem, unidades por dose e doses por dia, para obter o total, o detalhamento por medicamento e as orienta\u00e7\u00f5es sobre os limiares do CDC.<\/p>\n","protected":false},"author":3168,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[11],"tags":[61],"class_list":["post-2959","post","type-post","status-publish","format-standard","hentry","category-medicos","tag-farmacologia"],"acf":[],"_links":{"self":[{"href":"https:\/\/wpcalc.com\/pt\/wp-json\/wp\/v2\/posts\/2959","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wpcalc.com\/pt\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wpcalc.com\/pt\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wpcalc.com\/pt\/wp-json\/wp\/v2\/users\/3168"}],"replies":[{"embeddable":true,"href":"https:\/\/wpcalc.com\/pt\/wp-json\/wp\/v2\/comments?post=2959"}],"version-history":[{"count":0,"href":"https:\/\/wpcalc.com\/pt\/wp-json\/wp\/v2\/posts\/2959\/revisions"}],"wp:attachment":[{"href":"https:\/\/wpcalc.com\/pt\/wp-json\/wp\/v2\/media?parent=2959"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wpcalc.com\/pt\/wp-json\/wp\/v2\/categories?post=2959"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wpcalc.com\/pt\/wp-json\/wp\/v2\/tags?post=2959"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}