{"id":153,"date":"2026-10-03T11:57:34","date_gmt":"2026-10-03T10:57:34","guid":{"rendered":"https:\/\/wpcalc.com\/tr\/karboplatin-auc-doz\/"},"modified":"2026-10-03T11:57:34","modified_gmt":"2026-10-03T10:57:34","slug":"karboplatin-auc-doz","status":"publish","type":"post","link":"https:\/\/wpcalc.com\/tr\/tisbi\/karboplatin-auc-doz\/","title":{"rendered":"Karboplatin AUC Doz Hesaplay\u0131c\u0131"},"content":{"rendered":"<section class=\"not-prose calculator-box\" aria-labelledby=\"calculator-title\"><div class=\"flex items-baseline sm:items-center justify-between gap-2 sm:gap-3\"><div class=\"flex flex-col sm:flex-row sm:items-center gap-2\"><span class=\"icon icon-calculator text-primary-700! text-base! dark:text-primary-300!\" aria-hidden=\"true\"><\/span><h2 id=\"calculator-title\" class=\"text-lg font-display font-bold\">Karboplatin AUC Dozunu Hesaplay\u0131n<\/h2><\/div><div class=\"calcdash-favorite group\">\n  <button type=\"button\" class=\"favorite\" id=\"favorite\" data-favorite-id=\"153\" data-favorite-title=\"Karboplatin AUC Dozu\" data-favorite-url=\"https:\/\/wpcalc.com\/tr\/tisbi\/karboplatin-auc-doz\/\" data-favorite-excerpt=\"Karboplatin dozunu Calvert form\u00fcl\u00fcyle hesaplay\u0131n. GFR&#039;yi (Cockcroft-Gault) ve mg cinsinden dozu tahmin etmek i\u00e7in cinsiyet, ya\u015f, v\u00fccut a\u011f\u0131rl\u0131\u011f\u0131, serum kreatinini ve hedef AUC de\u011ferlerini girin.\" aria-label=\"Favorilere ekle\" data-favorite-icon=\"icon icon-pharmacology\">\n    <span class=\"icon icon-shape-star-empty\" aria-hidden=\"true\"><\/span>\n  <\/button>\n  <div class=\"calcdash-favorite__tip\" aria-hidden=\"true\">\n   <span class=\"favorite-tooltip\" id=\"favorite-tooltip\"><\/span>\n  <\/div>\n  <span class=\"sr-only\" role=\"status\" id=\"favorite-status\"><\/span>\n<\/div><\/div><form action=\"https:\/\/wpcalc.com\/tr\/tisbi\/karboplatin-auc-doz\/\" method=\"POST\" class=\"calculator\" id=\"calculator-153\" data-post=\"153\"><fieldset class=\"fieldset-input is-1\"><legend class=\"sr-only\">Giri\u015f alanlar\u0131<\/legend><div class=\"field is-single\" id=\"input-1\"><label for=\"field-1\">Cinsiyet<\/label><div class=\"grid grid-cols-1\"><select id=\"field-1\" name=\"cinsiyet\"><option value=\"1\">Erkek<\/option><option value=\"0.85\">Kad\u0131n<\/option><\/select><svg class=\"pointer-events-none col-start-1 row-start-1 mr-2 size-5 self-center justify-self-end text-gray-500 sm:size-4\" viewBox=\"0 0 16 16\" fill=\"currentColor\" aria-hidden=\"true\" data-slot=\"icon\">\n              <path fill-rule=\"evenodd\" d=\"M4.22 6.22a.75.75 0 0 1 1.06 0L8 8.94l2.72-2.72a.75.75 0 1 1 1.06 1.06l-3.25 3.25a.75.75 0 0 1-1.06 0L4.22 7.28a.75.75 0 0 1 0-1.06Z\" clip-rule=\"evenodd\" \/>\n            <\/svg><\/div><\/div><div class=\"field\" id=\"input-2\"><label for=\"field-2\">Ya\u015f<\/label><input type=\"number\" name=\"ya\" id=\"field-2\" aria-describedby=\"calc-unit-2\" placeholder=\"e.g. 25\" step=\"any\" value=\"25\"\/><div class=\"unit\" id=\"calc-unit-2\">y\u0131l<\/div><\/div><div class=\"field\" id=\"input-3\"><label for=\"field-3\">Kilo<\/label><div class=\"field-group\"><input type=\"number\" name=\"kilo\" id=\"field-3\" placeholder=\"e.g. 70\" step=\"any\" value=\"70\"\/><div class=\"grid grid-cols-1\"><select id=\"field-4\" name=\"birim\" aria-label=\"Birim\"><option value=\"1\">kg<\/option><option value=\"0.453592\">lb<\/option><\/select><svg class=\"pointer-events-none col-start-1 row-start-1 mr-2 size-5 self-center justify-self-end text-gray-500 sm:size-4\" viewBox=\"0 0 16 16\" fill=\"currentColor\" aria-hidden=\"true\" data-slot=\"icon\">\n              <path fill-rule=\"evenodd\" d=\"M4.22 6.22a.75.75 0 0 1 1.06 0L8 8.94l2.72-2.72a.75.75 0 1 1 1.06 1.06l-3.25 3.25a.75.75 0 0 1-1.06 0L4.22 7.28a.75.75 0 0 1 0-1.06Z\" clip-rule=\"evenodd\" \/>\n            <\/svg><\/div><\/div><\/div><div class=\"field\" id=\"input-4\"><label for=\"field-5\">Serum Kreatinini<\/label><input type=\"number\" name=\"serum_kreatinini\" id=\"field-5\" aria-describedby=\"calc-unit-5\" placeholder=\"e.g. 1.0\" step=\"any\" value=\"1\"\/><div class=\"unit\" id=\"calc-unit-5\">mg\/dL<\/div><\/div><div class=\"field\" id=\"input-5\"><label for=\"field-6\">Hedef AUC<\/label><input type=\"number\" name=\"hedef_auc\" id=\"field-6\" aria-describedby=\"calc-unit-6\" placeholder=\"e.g. 5\" step=\"any\" value=\"5\"\/><div class=\"unit\" id=\"calc-unit-6\">mg\/ml\/dk<\/div><\/div><\/fieldset><div class=\"buttons\"><button type=\"submit\" data-text=\"Yeniden hesapla\" id=\"calculate-button\" data-post=\"153\">Hesapla<\/button><button type=\"reset\">S\u0131f\u0131rla<\/button><\/div><div class=\"field is-checkbox hidden!\" id=\"field-auto-calc\"><input type=\"checkbox\" id=\"auto-calc\"><label for=\"auto-calc\">Otomatik hesapla<\/label><small>Etkinle\u015ftirilirse, herhangi bir de\u011feri de\u011fi\u015ftirdi\u011finizde sonu\u00e7 otomatik olarak g\u00fcncellenir.<\/small><\/div><div class=\"fieldset-result is-hidden\" aria-labelledby=\"result-title\" aria-live=\"polite\" role=\"region\"> <h3 class=\"result-title bg-gradient-to-r from-primary-50 to-gray-50 dark:from-primary-900 dark:to-gray-800\" id=\"result-title\"><span class=\"icon icon-s-pulse\" aria-hidden=\"true\"><\/span> Sonu\u00e7lar\u0131n\u0131z<\/h3><div class=\"result-box\"><div class=\"field-result\" id=\"output-1\"><span class=\"field-title\"><span>GFR<\/span><\/span><span class=\"field-value\" id=\"result-1\"><\/span><button type=\"button\" class=\"copy-result\" data-tooltip=\"Sonucu kopyala\" aria-label=\"Sonucu kopyala\"><span class=\"copy-icon icon icon-document-copy\" aria-hidden=\"true\"><\/span><\/button><\/div><div class=\"field-result\" id=\"output-2\"><span class=\"field-title\"><span>Karboplatin Dozu<\/span><\/span><span class=\"field-value\" id=\"result-2\"><\/span><button type=\"button\" class=\"copy-result\" data-tooltip=\"Sonucu kopyala\" aria-label=\"Sonucu kopyala\"><span class=\"copy-icon icon icon-document-copy\" aria-hidden=\"true\"><\/span><\/button><\/div><\/div><div class=\"result-actions\"><button type=\"button\" class=\"copy-link\"><svg viewBox=\"0 0 20 20\" fill=\"currentColor\" aria-hidden=\"true\"><path d=\"M12.232 4.232a2.5 2.5 0 0 1 3.536 3.536l-1.225 1.224a.75.75 0 0 0 1.061 1.06l1.224-1.224a4 4 0 0 0-5.656-5.656l-3 3a4 4 0 0 0 .225 5.865.75.75 0 0 0 .977-1.138 2.5 2.5 0 0 1-.142-3.667l3-3Z\"\/><path d=\"M11.603 7.963a.75.75 0 0 0-.977 1.138 2.5 2.5 0 0 1 .142 3.667l-3 3a2.5 2.5 0 0 1-3.536-3.536l1.225-1.224a.75.75 0 0 0-1.061-1.06l-1.224 1.224a4 4 0 1 0 5.656 5.656l3-3a4 4 0 0 0-.225-5.865Z\"\/><\/svg><span class=\"copy-link__text\">Bu hesaplaman\u0131n ba\u011flant\u0131s\u0131n\u0131 kopyala<\/span><\/button><span class=\"sr-only\" role=\"status\" id=\"copy-link-status\"><\/span><\/div><\/div><a href=\"#respond\" class=\"hidden transition-opacity duration-300 opacity-0 w-50 text-sm justify-center items-center gap-2 px-4 py-2 rounded bg-gray-200 text-gray-700 hover:bg-gray-300\" id=\"leave-comment\"><span class=\"icon icon-comments\" aria-hidden=\"true\"><\/span>Yorum b\u0131rak<\/a><\/form><\/section><section id=\"calc-reactions\" class=\"not-prose hidden my-12 bg-gradient-to-r from-primary-50 to-gray-50 border border-indigo-100 rounded-xl px-6 py-4 shadow-sm\" data-post=\"153\" aria-live=\"polite\" aria-labelledby=\"calc-reactions-title\"><p id=\"calc-reactions-title\" class=\"text-sm text-gray-500 text-center mb-2\">Bu sonu\u00e7 hakk\u0131nda ne d\u00fc\u015f\u00fcn\u00fcyorsunuz?<\/p><div role=\"group\" aria-labelledby=\"calc-reactions-title\" class=\"grid grid-cols-3 sm:flex sm:flex-row sm:justify-around gap-4 sm:items-center sm:flex-wrap\"><button type=\"button\" aria-pressed=\"false\" class=\"reaction-btn flex flex-col items-center gap-1 text-sm text-gray-700 hover:text-primary-600 cursor-pointer transition-transform hover:scale-105\" data-reaction=\"like\"><span class=\"reaction-count\" data-reaction-count=\"like\">0<\/span><span class=\"reaction text-3xl\" aria-hidden=\"true\">\ud83d\ude00 <\/span><span class=\"reaction-description font-medium\">Be\u011fendim <\/span><\/button><button type=\"button\" aria-pressed=\"false\" class=\"reaction-btn flex flex-col items-center gap-1 text-sm text-gray-700 hover:text-primary-600 cursor-pointer transition-transform hover:scale-105\" data-reaction=\"helpful\"><span class=\"reaction-count\" data-reaction-count=\"helpful\">0<\/span><span class=\"reaction text-3xl\" aria-hidden=\"true\">\ud83d\udca1 <\/span><span class=\"reaction-description font-medium\">Faydal\u0131 <\/span><\/button><button type=\"button\" aria-pressed=\"false\" class=\"reaction-btn flex flex-col items-center gap-1 text-sm text-gray-700 hover:text-primary-600 cursor-pointer transition-transform hover:scale-105\" data-reaction=\"confused\"><span class=\"reaction-count\" data-reaction-count=\"confused\">0<\/span><span class=\"reaction text-3xl\" aria-hidden=\"true\">\ud83d\ude15 <\/span><span class=\"reaction-description font-medium\">Kafam kar\u0131\u015ft\u0131 <\/span><\/button><button type=\"button\" aria-pressed=\"false\" class=\"reaction-btn flex flex-col items-center gap-1 text-sm text-gray-700 hover:text-primary-600 cursor-pointer transition-transform hover:scale-105\" data-reaction=\"disappointed\"><span class=\"reaction-count\" data-reaction-count=\"disappointed\">0<\/span><span class=\"reaction text-3xl\" aria-hidden=\"true\">\ud83d\ude1e <\/span><span class=\"reaction-description font-medium\">Hayal k\u0131r\u0131kl\u0131\u011f\u0131 <\/span><\/button><button type=\"button\" aria-pressed=\"false\" class=\"reaction-btn flex flex-col items-center gap-1 text-sm text-gray-700 hover:text-primary-600 cursor-pointer transition-transform hover:scale-105\" data-reaction=\"inaccurate\"><span class=\"reaction-count\" data-reaction-count=\"inaccurate\">0<\/span><span class=\"reaction text-3xl\" aria-hidden=\"true\">\u274c <\/span><span class=\"reaction-description font-medium\">Hatal\u0131 <\/span><\/button><\/div><div id=\"reaction-message\" class=\"hidden mt-8 rounded-md border border-primary-100 bg-white\/50 backdrop-blur-sm px-4 py-2 text-sm text-center shadow-sm\"><\/div><\/section><div class=\"calcdash-ad not-prose calcdash-ad--calc_result calcdash-ad--in-article\"><ins class=\"adsbygoogle\" style=\"display:block\" data-ad-client=\"ca-pub-1721569815777345\" data-ad-slot=\"6317458308\" data-ad-layout=\"in-article\" data-ad-format=\"fluid\"><\/ins><script>(adsbygoogle = window.adsbygoogle || []).push({});<\/script><\/div>\n<style id=\"wpcoderpro-inline-1\">.formula-box {\r\n\tborder-bottom: none !important;\r\n}<\/style><section class=\"formula-box\" aria-labelledby=\"formula-title\">\r\n\t<div id=\"formula-title\" class=\"not-prose font-display mb-4\"><span class=\"icon icon-formula\" aria-hidden=\"true\"><\/span><h2>Karboplatin AUC Dozu (Calvert Form\u00fcl\u00fc)<\/h2><\/div>\r\n\t<figure class=\"not-prose formula\">\r\n\t\t<figcaption class=\"formula-title\">Form\u00fcl<\/figcaption>\r\n\t\t<div class=\"text-base text-gray-800\" id=\"formula\">\n\\[ \\text{GFR} = \\frac{(140 - \\text{ya\u015f}) \\times \\text{a\u011f\u0131rl\u0131k (kg)}}{72 \\times \\text{serum kreatinini (mg\/dL)}} \\times 0.85 \\;\\text{(kad\u0131n ise)} \\]\n\\[ \\text{Karboplatin Dozu (mg)} = \\text{Hedef AUC} \\times (\\text{GFR} + 25) \\]\n<\/div>\r\n\t<\/figure>\r\n\t<\/p>\n<p><strong>Burada:<\/strong><\/p>\n<ul>\n<li>\\(\\text{GFR}\\) \u2014 glomer\u00fcler filtrasyon h\u0131z\u0131, Cockcroft-Gault denklemi ile tahmin edilir (mL\/dk)<\/li>\n<li>\\(\\text{ya\u015f}\\) \u2014 hastan\u0131n ya\u015f\u0131, y\u0131l cinsinden<\/li>\n<li>\\(\\text{a\u011f\u0131rl\u0131k}\\) \u2014 v\u00fccut a\u011f\u0131rl\u0131\u011f\u0131, kilogram cinsinden<\/li>\n<li>\\(\\text{serum kreatinini}\\) \u2014 serum kreatinini, mg\/dL cinsinden<\/li>\n<li>\\(0.85\\) \u2014 kad\u0131n hastalar i\u00e7in uygulanan d\u00fczeltme katsay\u0131s\u0131<\/li>\n<li>\\(\\text{Hedef AUC}\\) \u2014 istenen e\u011fri alt\u0131ndaki alan, yani konsantrasyon-zaman e\u011frisinin alt\u0131ndaki alan (mg\/mL\u00b7dk)<\/li>\n<li>\\(25\\) \u2014 karboplatinin renal olmayan klirensi (mL\/dk)<\/li>\n<\/ul>\n<p>\u0130lk denklem Cockcroft-Gault y\u00f6ntemiyle b\u00f6brek fonksiyonunu tahmin eder; ikincisi, yani Calvert form\u00fcl\u00fc, bu tahmini hedef ila\u00e7 maruziyeti (AUC) ile birle\u015ftirerek mg cinsinden karboplatin dozuna d\u00f6n\u00fc\u015ft\u00fcr\u00fcr.<\/p>\n<p>\r\n<\/section>\n<style id=\"wpcoderpro-inline-2\">.calculation-box {\r\n\tborder-bottom: none !important;\r\n}<\/style><section id=\"calculation\" class=\"calculation-box\" aria-labelledby=\"calculation-title\">\r\n\t<div id=\"calculation-title\" class=\"not-prose font-display\"><span class=\"icon icon-unordered-list\" aria-hidden=\"true\"><\/span><h2>Karboplatin AUC Dozu \u2013 Hesaplama \u00d6rne\u011fi<\/h2><\/div>\r\n\r\n<\/p>\n<p><strong>\u00d6rnek:<\/strong> 70 kg a\u011f\u0131rl\u0131\u011f\u0131nda, serum kreatinini 1,0 mg\/dL olan 25 ya\u015f\u0131ndaki bir erke\u011fe hedef AUC 5 ile karboplatin re\u00e7ete edilmi\u015ftir.<\/p>\n<p>\\[ \\text{GFR} = \\frac{(140 - 25) \\times 70}{72 \\times 1.0} = \\frac{8050}{72} \\approx 111.81 \\;\\text{mL\/dk} \\]<\/p>\n<p>\\[ \\text{Doz} = 5 \\times (111.81 + 25) = 5 \\times 136.81 \\approx 684.03 \\;\\text{mg} \\]<\/p>\n<p><strong>Sonu\u00e7:<\/strong> GFR \u2248 111,81 mL\/dk ve karboplatin dozu \u2248 684,03 mg. Bunlar hesaplay\u0131c\u0131n\u0131n varsay\u0131lan de\u011ferleriyle e\u015fle\u015fir; b\u00f6ylece do\u011frudan yeniden \u00fcretebilirsiniz.<\/p>\n<p>\n\r\n<\/section>\n<h2>Hesaplay\u0131c\u0131 nas\u0131l kullan\u0131l\u0131r<\/h2>\n<ol>\n<li>Hastan\u0131n <strong>Cinsiyetini<\/strong> se\u00e7in (Erkek veya Kad\u0131n). Kad\u0131n hastalar i\u00e7in GFR tahminine 0,85 katsay\u0131s\u0131 uygulan\u0131r.<\/li>\n<li>Hastan\u0131n <strong>Ya\u015f\u0131n\u0131<\/strong> y\u0131l cinsinden girin.<\/li>\n<li><strong>V\u00fccut A\u011f\u0131rl\u0131\u011f\u0131n\u0131<\/strong> girin ve birimi se\u00e7in \u2014 <code>kg<\/code> veya <code>lb<\/code>. Libre de\u011feri otomatik olarak kilograma d\u00f6n\u00fc\u015ft\u00fcr\u00fcl\u00fcr.<\/li>\n<li>Hastan\u0131n son laboratuvar sonu\u00e7lar\u0131ndan <strong>Serum Kreatinini<\/strong> de\u011ferini mg\/dL cinsinden girin.<\/li>\n<li>Re\u00e7ete edilen <strong>Hedef AUC<\/strong> de\u011ferini mg\/mL\u00b7dk cinsinden girin \u2014 tedavi protokol\u00fcne g\u00f6re genellikle 4 ile 7 aras\u0131ndad\u0131r.<\/li>\n<li>Sonu\u00e7lar\u0131 okuyun: mL\/dk cinsinden tahmini <strong>GFR<\/strong> ve mg cinsinden <strong>Karboplatin Dozu<\/strong>.<\/li>\n<\/ol>\n<h2>Calvert form\u00fcl\u00fc ne anlama geliyor<\/h2>\n<p>Karboplatin; yumurtal\u0131k, akci\u011fer, ba\u015f-boyun kanserleri ve daha bir\u00e7ok kanser t\u00fcr\u00fcn\u00fcn tedavisinde kullan\u0131lan platin bazl\u0131 bir kemoterapi ilac\u0131d\u0131r. \u00c7o\u011fu sitotoksik ilac\u0131n aksine dozu v\u00fccut y\u00fczey alan\u0131na de\u011fil, hedef bir <em>e\u011fri alt\u0131ndaki alana<\/em> (AUC) g\u00f6re belirlenir. AUC, zaman i\u00e7indeki toplam ila\u00e7 maruziyetini tan\u0131mlar: daha y\u00fcksek AUC, daha fazla ila\u00e7 etkisi \u2014 ve daha fazla toksisite demektir.<\/p>\n<p>1989'da tan\u0131t\u0131lan Calvert form\u00fcl\u00fc, istenen maruziyeti bunu sa\u011flayacak dozla ili\u015fkilendirir: doz = hedef AUC \u00d7 (GFR + 25). GFR terimi renal klirensi temsil eder, \u00e7\u00fcnk\u00fc karboplatin neredeyse tamamen b\u00f6brekler taraf\u0131ndan at\u0131l\u0131r; 25 mL\/dk sabiti ise k\u00fc\u00e7\u00fck renal olmayan klirensi hesaba katar. Klirens hastalar aras\u0131nda geni\u015f \u00f6l\u00e7\u00fcde de\u011fi\u015fti\u011finden, bu yakla\u015f\u0131m dozu sabit bir mg\/m\u00b2 rejiminden \u00e7ok daha iyi bireyselle\u015ftirir.<\/p>\n<p>Hesaplay\u0131c\u0131, GFR'yi ya\u015f, v\u00fccut a\u011f\u0131rl\u0131\u011f\u0131, cinsiyet ve serum kreatinininden kreatinin klirensini t\u00fcreten Cockcroft-Gault denklemiyle tahmin eder. Kad\u0131nlara ait 0,85 katsay\u0131s\u0131, kad\u0131nlar\u0131n ortalama olarak daha d\u00fc\u015f\u00fck kas k\u00fctlesine ve dolay\u0131s\u0131yla daha d\u00fc\u015f\u00fck kreatin \u00fcretimine sahip olmas\u0131n\u0131 yans\u0131t\u0131r.<\/p>\n<p>Sonucun yorumlanmas\u0131: elde edilen doz, se\u00e7ilen AUC i\u00e7in uygulanacak toplam karboplatin miktar\u0131d\u0131r (mg cinsinden); genellikle seyreltilerek 30\u201360 dakika boyunca inf\u00fcze edilir. Tipik hedefler kombine rejimlerde AUC 4\u20136, tek ajanl\u0131 tedavide AUC 5\u20137'dir; ancak do\u011fru de\u011fer her zaman tedavi protokol\u00fcnden gelir.<\/p>\n<h2>Varsay\u0131mlar, s\u0131n\u0131rlamalar ve pratik ipu\u00e7lar\u0131<\/h2>\n<ul>\n<li><strong>Yaln\u0131zca b\u00f6brek fonksiyonu tahmini.<\/strong> Cockcroft-Gault bir yakla\u015f\u0131md\u0131r. B\u00f6brek fonksiyonu karars\u0131z olan, a\u015f\u0131r\u0131 kilolu veya kilosu \u00e7ok d\u00fc\u015f\u00fck ya da kas k\u00fctlesi \u00e7ok az olan hastalarda Calvert dozlamas\u0131 i\u00e7in \u00f6l\u00e7\u00fclm\u00fc\u015f veya radyon\u00fcklid GFR tercih edilir \u2014 bu, bilinen bir dozlama hata kayna\u011f\u0131d\u0131r.<\/li>\n<li><strong>Kreatinin birimleri \u00f6nemlidir.<\/strong> Hesaplay\u0131c\u0131 serum kreatininini mg\/dL cinsinden bekler. Laboratuvar\u0131n\u0131z \u00b5mol\/L olarak rapor ediyorsa, de\u011feri girmeden \u00f6nce 88,4'e b\u00f6l\u00fcn.<\/li>\n<li><strong>Ger\u00e7ek v\u00fccut a\u011f\u0131rl\u0131\u011f\u0131n\u0131 dikkatli kullan\u0131n.<\/strong> Cockcroft-Gault ger\u00e7ek v\u00fccut a\u011f\u0131rl\u0131\u011f\u0131yla geli\u015ftirilmi\u015ftir; belirgin obez veya \u00e7ok zay\u0131f hastalarda bir\u00e7ok protokol bunun yerine d\u00fczeltilmi\u015f veya ideal v\u00fccut a\u011f\u0131rl\u0131\u011f\u0131 kullan\u0131r. Kurumsal rehberinizi kontrol edin.<\/li>\n<li><strong>A\u015f\u0131r\u0131 tahmin riski.<\/strong> GFR'nin fazla tahmin edilmesi a\u015f\u0131r\u0131 doza ve karboplatinin doz s\u0131n\u0131rlay\u0131c\u0131 toksisitesi olan miyelosupresyona yol a\u00e7ar. \u015e\u00fcphe durumunda hekimler genellikle GFR tahminine bir \u00fcst s\u0131n\u0131r koyar.<\/li>\n<li><strong>Karboplatin duyars\u0131zla\u015ft\u0131rma veya y\u00fcksek doz protokolleri i\u00e7in de\u011fildir.<\/strong> Baz\u0131 durumlarda farkl\u0131 form\u00fcller veya \u00f6l\u00e7\u00fclm\u00fc\u015f klirens kullan\u0131l\u0131r.<\/li>\n<li><strong>Klinik karar arac\u0131.<\/strong> Bu hesaplay\u0131c\u0131 do\u011frulama ve e\u011fitim ama\u00e7l\u0131d\u0131r; nihai doz, bir onkolog veya klinik eczac\u0131 taraf\u0131ndan ilgili protokole g\u00f6re onaylanmal\u0131d\u0131r.<\/li>\n<\/ul>\n<p>\u0130lgili hesaplamalar i\u00e7in, ila\u00e7 at\u0131l\u0131m\u0131n\u0131 tahmin etmek \u00fczere <a href=\"https:\/\/wpcalc.com\/tr\/tisbi\/ilac-yari-omru\/\">Yar\u0131 \u00d6m\u00fcr S\u00fcresi hesaplay\u0131c\u0131s\u0131na<\/a>, inf\u00fczyon h\u0131z\u0131 hesaplamalar\u0131 i\u00e7in <a href=\"https:\/\/wpcalc.com\/tr\/tisbi\/doz-infuzyon-hizi\/\">Doz \u0130nf\u00fczyon hesaplay\u0131c\u0131s\u0131na<\/a> veya ciddi b\u00f6brek yetmezli\u011fi olan hastalarda diyaliz yeterlili\u011fini de\u011ferlendirmek i\u00e7in <a href=\"https:\/\/wpcalc.com\/tr\/tisbi\/diyaliz-dozu\/\">Diyaliz Dozu (Kt\/V) hesaplay\u0131c\u0131s\u0131na<\/a> bak\u0131n.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Karboplatin dozunu Calvert form\u00fcl\u00fcyle hesaplay\u0131n. GFR'yi (Cockcroft-Gault) ve mg cinsinden dozu tahmin etmek i\u00e7in cinsiyet, ya\u015f, v\u00fccut a\u011f\u0131rl\u0131\u011f\u0131, serum kreatinini ve hedef AUC de\u011ferlerini girin.<\/p>\n","protected":false},"author":3168,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[11],"tags":[60],"class_list":["post-153","post","type-post","status-publish","format-standard","hentry","category-tisbi","tag-farmakoloji"],"acf":[],"_links":{"self":[{"href":"https:\/\/wpcalc.com\/tr\/wp-json\/wp\/v2\/posts\/153","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wpcalc.com\/tr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wpcalc.com\/tr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wpcalc.com\/tr\/wp-json\/wp\/v2\/users\/3168"}],"replies":[{"embeddable":true,"href":"https:\/\/wpcalc.com\/tr\/wp-json\/wp\/v2\/comments?post=153"}],"version-history":[{"count":4,"href":"https:\/\/wpcalc.com\/tr\/wp-json\/wp\/v2\/posts\/153\/revisions"}],"predecessor-version":[{"id":2890,"href":"https:\/\/wpcalc.com\/tr\/wp-json\/wp\/v2\/posts\/153\/revisions\/2890"}],"wp:attachment":[{"href":"https:\/\/wpcalc.com\/tr\/wp-json\/wp\/v2\/media?parent=153"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wpcalc.com\/tr\/wp-json\/wp\/v2\/categories?post=153"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wpcalc.com\/tr\/wp-json\/wp\/v2\/tags?post=153"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}