{"id":3828,"date":"2026-10-07T12:23:40","date_gmt":"2026-10-07T11:23:40","guid":{"rendered":"https:\/\/wpcalc.com\/tr\/kimya\/bolusme-katsayisi-hesaplama\/"},"modified":"2026-10-07T12:23:40","modified_gmt":"2026-10-07T11:23:40","slug":"bolusme-katsayisi-hesaplama","status":"publish","type":"post","link":"https:\/\/wpcalc.com\/tr\/kimya\/bolusme-katsayisi-hesaplama\/","title":{"rendered":"B\u00f6l\u00fc\u015fme Katsay\u0131s\u0131 Hesaplama"},"content":{"rendered":"<section class=\"not-prose calculator-box\" aria-labelledby=\"calculator-title\"><div class=\"flex items-baseline sm:items-center justify-between gap-2 sm:gap-3\"><div class=\"flex flex-col sm:flex-row sm:items-center gap-2\"><span class=\"icon icon-calculator text-primary-700! text-base! dark:text-primary-300!\" aria-hidden=\"true\"><\/span><h2 id=\"calculator-title\" class=\"text-lg font-display font-bold\">Bir \u00e7\u00f6z\u00fcnenin iki kar\u0131\u015fmayan s\u0131v\u0131 aras\u0131ndaki da\u011f\u0131l\u0131m\u0131n\u0131 hesaplay\u0131n<\/h2><\/div><div class=\"calcdash-favorite group\">\n  <button type=\"button\" class=\"favorite\" id=\"favorite\" data-favorite-id=\"3828\" data-favorite-title=\"B\u00f6l\u00fc\u015fme katsay\u0131s\u0131\" data-favorite-url=\"https:\/\/wpcalc.com\/tr\/kimya\/bolusme-katsayisi-hesaplama\/\" data-favorite-excerpt=\"Bir \u00e7\u00f6z\u00fcnenin organik ve sulu fazlardaki denge deri\u015fimlerini girin; b\u00f6l\u00fc\u015fme katsay\u0131s\u0131 P, log P ve \u00e7\u00f6z\u00fcnenin her katmandaki y\u00fczdesini an\u0131nda \u00f6\u011frenin.\" aria-label=\"Favorilere ekle\" data-favorite-icon=\"icon icon-biology\">\n    <span class=\"icon icon-shape-star-empty\" aria-hidden=\"true\"><\/span>\n  <\/button>\n  <div class=\"calcdash-favorite__tip\" aria-hidden=\"true\">\n   <span class=\"favorite-tooltip\" id=\"favorite-tooltip\"><\/span>\n  <\/div>\n  <span class=\"sr-only\" role=\"status\" id=\"favorite-status\"><\/span>\n<\/div><\/div><form action=\"https:\/\/wpcalc.com\/tr\/kimya\/bolusme-katsayisi-hesaplama\/\" method=\"POST\" class=\"calculator\" id=\"calculator-3828\" data-post=\"3828\"><fieldset class=\"fieldset-input is-2\"><legend class=\"sr-only\">Giri\u015f alanlar\u0131<\/legend><div class=\"field has-term\" id=\"input-1\"><label for=\"field-1\">Organik fazdaki deri\u015fim<\/label><div class=\"term\">Corg<\/div>  <div class=\"absolute bottom-0 left-16 top-8 w-2 h-0.5 bg-blue-500\"><\/div><div class=\"field-group\"><input type=\"text\" name=\"organik_fazdaki_deriim\" id=\"field-1\" aria-describedby=\"calc-info-1\" data-number inputmode=\"decimal\" autocomplete=\"off\" spellcheck=\"false\" placeholder=\"e.g. 12\" min=\"0\" value=\"12\"\/><div class=\"grid grid-cols-1\"><select id=\"field-2\" name=\"birim\" aria-label=\"Birim\"><option value=\"M\">mol\/L<\/option><option value=\"mM\" selected>mmol\/L<\/option><option value=\"uM\">\u00b5mol\/L<\/option><\/select><svg class=\"pointer-events-none col-start-1 row-start-1 mr-2 size-5 self-center justify-self-end text-gray-500 sm:size-4\" viewBox=\"0 0 16 16\" fill=\"currentColor\" aria-hidden=\"true\" data-slot=\"icon\">\n              <path fill-rule=\"evenodd\" d=\"M4.22 6.22a.75.75 0 0 1 1.06 0L8 8.94l2.72-2.72a.75.75 0 1 1 1.06 1.06l-3.25 3.25a.75.75 0 0 1-1.06 0L4.22 7.28a.75.75 0 0 1 0-1.06Z\" clip-rule=\"evenodd\" \/>\n            <\/svg><\/div><\/div><small id=\"calc-info-1\">\u00c7\u00f6z\u00fcnenin polar olmayan (organik) katmandaki denge deri\u015fimi<\/small><\/div><div class=\"field has-term\" id=\"input-2\"><label for=\"field-3\">Sulu fazdaki deri\u015fim<\/label><div class=\"term\">Caq<\/div>  <div class=\"absolute bottom-0 left-16 top-8 w-2 h-0.5 bg-blue-500\"><\/div><div class=\"field-group\"><input type=\"text\" name=\"sulu_fazdaki_deriim\" id=\"field-3\" aria-describedby=\"calc-info-3\" data-number inputmode=\"decimal\" autocomplete=\"off\" spellcheck=\"false\" placeholder=\"e.g. 3\" min=\"0\" value=\"3\"\/><div class=\"grid grid-cols-1\"><select id=\"field-4\" name=\"unit\" aria-label=\"Unit\"><option value=\"M\">mol\/L<\/option><option value=\"mM\" selected>mmol\/L<\/option><option value=\"uM\">\u00b5mol\/L<\/option><\/select><svg class=\"pointer-events-none col-start-1 row-start-1 mr-2 size-5 self-center justify-self-end text-gray-500 sm:size-4\" viewBox=\"0 0 16 16\" fill=\"currentColor\" aria-hidden=\"true\" data-slot=\"icon\">\n              <path fill-rule=\"evenodd\" d=\"M4.22 6.22a.75.75 0 0 1 1.06 0L8 8.94l2.72-2.72a.75.75 0 1 1 1.06 1.06l-3.25 3.25a.75.75 0 0 1-1.06 0L4.22 7.28a.75.75 0 0 1 0-1.06Z\" clip-rule=\"evenodd\" \/>\n            <\/svg><\/div><\/div><small id=\"calc-info-3\">\u00c7\u00f6z\u00fcnenin su katman\u0131ndaki denge deri\u015fimi<\/small><\/div><\/fieldset><div class=\"buttons\"><button type=\"submit\" data-text=\"Yeniden hesapla\" id=\"calculate-button\" data-post=\"3828\">Hesapla<\/button><button type=\"reset\">S\u0131f\u0131rla<\/button><\/div><div class=\"field is-checkbox hidden!\" id=\"field-auto-calc\"><input type=\"checkbox\" id=\"auto-calc\"><label for=\"auto-calc\">Otomatik hesapla<\/label><small>Etkinle\u015ftirilirse, herhangi bir de\u011feri de\u011fi\u015ftirdi\u011finizde sonu\u00e7 otomatik olarak g\u00fcncellenir.<\/small><\/div><div class=\"fieldset-result is-hidden\" aria-labelledby=\"result-title\" aria-live=\"polite\" role=\"region\"> <h3 class=\"result-title bg-gradient-to-r from-primary-50 to-gray-50 dark:from-primary-900 dark:to-gray-800\" id=\"result-title\"><span class=\"icon icon-s-pulse\" aria-hidden=\"true\"><\/span> B\u00f6l\u00fcnme sonu\u00e7lar\u0131<\/h3><div class=\"result-box\"><div class=\"field-result\" id=\"output-1\"><span class=\"field-title\"><span>B\u00f6l\u00fcnme katsay\u0131s\u0131<\/span><span class=\"result-term\">P<\/span><\/span><span class=\"field-value\" id=\"result-1\"><\/span><button type=\"button\" class=\"copy-result\" data-tooltip=\"Sonucu kopyala\" aria-label=\"Sonucu kopyala\"><span class=\"copy-icon icon icon-document-copy\" aria-hidden=\"true\"><\/span><\/button><\/div><div class=\"field-result\" id=\"output-2\"><span class=\"field-title\"><span>log P<\/span><span class=\"result-term\">log P<\/span><\/span><span class=\"field-value\" id=\"result-2\"><\/span><button type=\"button\" class=\"copy-result\" data-tooltip=\"Sonucu kopyala\" aria-label=\"Sonucu kopyala\"><span class=\"copy-icon icon icon-document-copy\" aria-hidden=\"true\"><\/span><\/button><\/div><div class=\"field-result\" id=\"output-3\"><span class=\"field-title\"><span>Dengede organik fazda kalan \u00e7\u00f6z\u00fcnen<\/span><\/span><span class=\"field-value\" id=\"result-3\" data-unit=\"%\"><\/span><button type=\"button\" class=\"copy-result\" data-tooltip=\"Sonucu kopyala\" aria-label=\"Sonucu kopyala\"><span class=\"copy-icon icon icon-document-copy\" aria-hidden=\"true\"><\/span><\/button><\/div><div class=\"field-result\" id=\"output-4\"><span class=\"field-title\"><span>Dengede sulu fazda kalan \u00e7\u00f6z\u00fcnen<\/span><\/span><span class=\"field-value\" id=\"result-4\" data-unit=\"%\"><\/span><button type=\"button\" class=\"copy-result\" data-tooltip=\"Sonucu kopyala\" aria-label=\"Sonucu kopyala\"><span class=\"copy-icon icon icon-document-copy\" aria-hidden=\"true\"><\/span><\/button><\/div><div class=\"field-result is-column\" id=\"output-5\"><span class=\"field-title\"><span>Yorum<\/span><\/span><span class=\"field-value\" id=\"result-5\"><\/span><button type=\"button\" class=\"copy-result\" data-tooltip=\"Sonucu kopyala\" aria-label=\"Sonucu kopyala\"><span class=\"copy-icon icon icon-document-copy\" aria-hidden=\"true\"><\/span><\/button><\/div><div class=\"field-result is-column\" id=\"output-6\"><span class=\"field-title\"><span>Hesaplama ayr\u0131nt\u0131lar\u0131<\/span><\/span><span class=\"field-value\" id=\"result-6\"><\/span><button type=\"button\" class=\"copy-result\" data-tooltip=\"Sonucu kopyala\" aria-label=\"Sonucu kopyala\"><span class=\"copy-icon icon icon-document-copy\" aria-hidden=\"true\"><\/span><\/button><\/div><\/div><div class=\"result-actions\"><button type=\"button\" class=\"copy-link\"><svg viewBox=\"0 0 20 20\" fill=\"currentColor\" aria-hidden=\"true\"><path d=\"M12.232 4.232a2.5 2.5 0 0 1 3.536 3.536l-1.225 1.224a.75.75 0 0 0 1.061 1.06l1.224-1.224a4 4 0 0 0-5.656-5.656l-3 3a4 4 0 0 0 .225 5.865.75.75 0 0 0 .977-1.138 2.5 2.5 0 0 1-.142-3.667l3-3Z\"\/><path d=\"M11.603 7.963a.75.75 0 0 0-.977 1.138 2.5 2.5 0 0 1 .142 3.667l-3 3a2.5 2.5 0 0 1-3.536-3.536l1.225-1.224a.75.75 0 0 0-1.061-1.06l-1.224 1.224a4 4 0 1 0 5.656 5.656l3-3a4 4 0 0 0-.225-5.865Z\"\/><\/svg><span class=\"copy-link__text\">Bu hesaplaman\u0131n ba\u011flant\u0131s\u0131n\u0131 kopyala<\/span><\/button><span class=\"sr-only\" role=\"status\" id=\"copy-link-status\"><\/span><\/div><\/div><a href=\"#respond\" class=\"hidden transition-opacity duration-300 opacity-0 w-50 text-sm justify-center items-center gap-2 px-4 py-2 rounded bg-gray-200 text-gray-700 hover:bg-gray-300\" id=\"leave-comment\"><span class=\"icon icon-comments\" aria-hidden=\"true\"><\/span>Yorum b\u0131rak<\/a><\/form><\/section><section id=\"calc-reactions\" class=\"not-prose hidden my-12 bg-gradient-to-r from-primary-50 to-gray-50 border border-indigo-100 rounded-xl px-6 py-4 shadow-sm\" data-post=\"3828\" aria-live=\"polite\" aria-labelledby=\"calc-reactions-title\"><p id=\"calc-reactions-title\" class=\"text-sm text-gray-500 text-center mb-2\">Bu sonu\u00e7 hakk\u0131nda ne d\u00fc\u015f\u00fcn\u00fcyorsunuz?<\/p><div role=\"group\" aria-labelledby=\"calc-reactions-title\" class=\"grid grid-cols-3 sm:flex sm:flex-row sm:justify-around gap-4 sm:items-center sm:flex-wrap\"><button type=\"button\" aria-pressed=\"false\" class=\"reaction-btn flex flex-col items-center gap-1 text-sm text-gray-700 hover:text-primary-600 cursor-pointer transition-transform hover:scale-105\" data-reaction=\"like\"><span class=\"reaction-count\" data-reaction-count=\"like\">0<\/span><span class=\"reaction text-3xl\" aria-hidden=\"true\">\ud83d\ude00 <\/span><span class=\"reaction-description font-medium\">Be\u011fendim <\/span><\/button><button type=\"button\" aria-pressed=\"false\" class=\"reaction-btn flex flex-col items-center gap-1 text-sm text-gray-700 hover:text-primary-600 cursor-pointer transition-transform hover:scale-105\" data-reaction=\"helpful\"><span class=\"reaction-count\" data-reaction-count=\"helpful\">0<\/span><span class=\"reaction text-3xl\" aria-hidden=\"true\">\ud83d\udca1 <\/span><span class=\"reaction-description font-medium\">Faydal\u0131 <\/span><\/button><button type=\"button\" aria-pressed=\"false\" class=\"reaction-btn flex flex-col items-center gap-1 text-sm text-gray-700 hover:text-primary-600 cursor-pointer transition-transform hover:scale-105\" data-reaction=\"confused\"><span class=\"reaction-count\" data-reaction-count=\"confused\">0<\/span><span class=\"reaction text-3xl\" aria-hidden=\"true\">\ud83d\ude15 <\/span><span class=\"reaction-description font-medium\">Kafam kar\u0131\u015ft\u0131 <\/span><\/button><button type=\"button\" aria-pressed=\"false\" class=\"reaction-btn flex flex-col items-center gap-1 text-sm text-gray-700 hover:text-primary-600 cursor-pointer transition-transform hover:scale-105\" data-reaction=\"disappointed\"><span class=\"reaction-count\" data-reaction-count=\"disappointed\">0<\/span><span class=\"reaction text-3xl\" aria-hidden=\"true\">\ud83d\ude1e <\/span><span class=\"reaction-description font-medium\">Hayal k\u0131r\u0131kl\u0131\u011f\u0131 <\/span><\/button><button type=\"button\" aria-pressed=\"false\" class=\"reaction-btn flex flex-col items-center gap-1 text-sm text-gray-700 hover:text-primary-600 cursor-pointer transition-transform hover:scale-105\" data-reaction=\"inaccurate\"><span class=\"reaction-count\" data-reaction-count=\"inaccurate\">0<\/span><span class=\"reaction text-3xl\" aria-hidden=\"true\">\u274c <\/span><span class=\"reaction-description font-medium\">Hatal\u0131 <\/span><\/button><\/div><div id=\"reaction-message\" class=\"hidden mt-8 rounded-md border border-primary-100 bg-white\/50 backdrop-blur-sm px-4 py-2 text-sm text-center shadow-sm\"><\/div><\/section><div class=\"calcdash-ad not-prose calcdash-ad--calc_result calcdash-ad--in-article\"><ins class=\"adsbygoogle\" style=\"display:block\" data-ad-client=\"ca-pub-1721569815777345\" data-ad-slot=\"6317458308\" data-ad-layout=\"in-article\" data-ad-format=\"fluid\"><\/ins><script>(adsbygoogle = window.adsbygoogle || []).push({});<\/script><\/div>\n<style id=\"wpcoderpro-inline-1\">.formula-box {\r\n\tborder-bottom: none !important;\r\n}<\/style><section class=\"formula-box\" aria-labelledby=\"formula-title\">\r\n\t<div id=\"formula-title\" class=\"not-prose font-display mb-4\"><span class=\"icon icon-formula\" aria-hidden=\"true\"><\/span><h2>B\u00f6l\u00fc\u015fme Katsay\u0131s\u0131 Form\u00fcl\u00fc<\/h2><\/div>\r\n\t<figure class=\"not-prose formula\">\r\n\t\t<figcaption class=\"formula-title\">Form\u00fcl<\/figcaption>\r\n\t\t<div class=\"text-base text-gray-800\" id=\"formula\">\\[ P = \\frac{C_{org}}{C_{aq}} \\qquad \\log P = \\log_{10} P \\]<\/div>\r\n\t<\/figure>\r\n\t<\/p>\n<p><strong>Buradaki semboller:<\/strong><\/p>\n<ul>\n<li>\\(P\\) \u2014 b\u00f6l\u00fc\u015fme katsay\u0131s\u0131 (birimsiz)<\/li>\n<li>\\(C_{org}\\) \u2014 \u00e7\u00f6z\u00fcnenin organik fazdaki denge deri\u015fimi (mol\/L)<\/li>\n<li>\\(C_{aq}\\) \u2014 \u00e7\u00f6z\u00fcnenin sulu fazdaki denge deri\u015fimi (mol\/L)<\/li>\n<li>\\(\\log P\\) \u2014 \\(P\\)'nin 10 taban\u0131nda logaritmas\u0131; lipofilikli\u011fi bildirmenin standart yolu<\/li>\n<\/ul>\n<p>Form\u00fcl, bir \u00e7\u00f6z\u00fcnenin birbiriyle kar\u0131\u015fmayan iki s\u0131v\u0131 aras\u0131ndaki denge da\u011f\u0131l\u0131m\u0131n\u0131 ifade eder: oran b\u00fcy\u00fcd\u00fck\u00e7e, \u00e7\u00f6z\u00fcnen su yerine organik (kutupsuz) katman\u0131 o kadar g\u00fc\u00e7l\u00fc tercih eder. \u0130ki deri\u015fim de b\u00f6lme i\u015fleminden \u00f6nce ayn\u0131 birime d\u00f6n\u00fc\u015ft\u00fcr\u00fcld\u00fc\u011f\u00fc i\u00e7in \\(P\\)'nin birimi yoktur.<\/p>\n<p>E\u015fit hacimli iki faz aras\u0131nda denge kuruldu\u011funda, \u00e7\u00f6z\u00fcnenin her bir katmanda kalan kesri do\u011frudan \\(P\\)'den gelir:<\/p>\n<p>\\[ f_{org} = \\frac{P}{1+P} \\qquad f_{aq} = \\frac{1}{1+P} \\]\r\n<\/section>\n<style id=\"wpcoderpro-inline-2\">.calculation-box {\r\n\tborder-bottom: none !important;\r\n}<\/style><section id=\"calculation\" class=\"calculation-box\" aria-labelledby=\"calculation-title\">\r\n\t<div id=\"calculation-title\" class=\"not-prose font-display\"><span class=\"icon icon-unordered-list\" aria-hidden=\"true\"><\/span><h2>B\u00f6l\u00fc\u015fme Katsay\u0131s\u0131 \u2013 Hesaplama \u00d6rne\u011fi<\/h2><\/div>\r\n\r\n<p>{formula}<\/p>\n<p><strong>\u00d6rnek:<\/strong> bir su numunesi e\u015fit hacimde organik \u00e7\u00f6z\u00fcc\u00fcyle \u00e7alkaland\u0131ktan sonra yap\u0131lan analizde, \u00e7\u00f6z\u00fcnenin deri\u015fimi organik katmanda 12 mmol\/L, su katman\u0131nda 3 mmol\/L bulunuyor.<\/p>\n<p>\\[ C_{org} = 12\\ \\text{mM} = 0.012\\ \\text{mol\/L}, \\quad C_{aq} = 3\\ \\text{mM} = 0.003\\ \\text{mol\/L} \\]<\/p>\n<p>\\[ P = \\frac{0.012}{0.003} = 4 \\]<\/p>\n<p>\\[ \\log P = \\log_{10} 4 \\approx 0.602 \\]<\/p>\n<p>\\[ f_{org} = \\frac{4}{1+4} = 0.80 = 80\\%, \\quad f_{aq} = 20\\% \\]<\/p>\n<p><strong>Sonu\u00e7:<\/strong> \\(P = 4\\), \\(\\log P \\approx 0.60\\). E\u015fit faz hacimlerinde \u00e7\u00f6z\u00fcnenin %80'i organik katmana ge\u00e7er, %20'si suda kal\u0131r \u2014 bile\u015fik hafif lipofiliktir.<\/p>\n<p>{\/formula}<\/p>\n\r\n<\/section>\n<h2>Hesaplay\u0131c\u0131 Nas\u0131l Kullan\u0131l\u0131r?<\/h2>\n<ol>\n<li>Denge h\u00e2lindeki <strong>Organik fazdaki deri\u015fimi<\/strong> girin ve a\u00e7\u0131l\u0131r listeden birimini (mol\/L, mmol\/L veya \u00b5mol\/L) se\u00e7in.<\/li>\n<li><strong>Sulu fazdaki deri\u015fimi<\/strong> kendi birimiyle girin. Her iki de\u011fer de ayn\u0131 \u00e7\u00f6z\u00fcneni, katmanlar dengeye geldikten sonra ayn\u0131 s\u0131cakl\u0131kta tan\u0131mlamal\u0131d\u0131r.<\/li>\n<li>Sonu\u00e7lar\u0131 okuyun: <strong>b\u00f6l\u00fc\u015fme katsay\u0131s\u0131<\/strong>, <strong>log P<\/strong>, (e\u015fit hacimler i\u00e7in) <strong>her fazdaki \u00e7\u00f6z\u00fcnen y\u00fczdesi<\/strong>; ayr\u0131ca otomatik yorum ve ad\u0131m ad\u0131m hesaplama d\u00f6k\u00fcm\u00fc.<\/li>\n<\/ol>\n<h2>B\u00f6l\u00fc\u015fme Katsay\u0131s\u0131 Nedir?<\/h2>\n<p>Bir \u00e7\u00f6z\u00fcnen, birbiriyle kar\u0131\u015fmayan iki s\u0131v\u0131yla \u2014 tipik olarak su ve oktanol, eter ya da diklorometan gibi bir organik \u00e7\u00f6z\u00fcc\u00fcyle \u2014 \u00e7alkaland\u0131\u011f\u0131nda, dengeye ula\u015f\u0131ncaya kadar iki katman aras\u0131nda da\u011f\u0131l\u0131r. B\u00f6l\u00fc\u015fme katsay\u0131s\u0131 \\(P\\) (\\(K_D\\) bi\u00e7iminde de yaz\u0131l\u0131r; da\u011f\u0131lma katsay\u0131s\u0131 olarak da bilinir), \u00e7\u00f6z\u00fcnenin organik fazdaki denge deri\u015fiminin sulu fazdaki denge deri\u015fimine oran\u0131d\u0131r. Bu, belirli bir s\u0131cakl\u0131kta \u00e7\u00f6z\u00fcnen\u2013\u00e7\u00f6z\u00fcc\u00fc \u00e7iftine ait termodinamik bir \u00f6zelliktir: ne kadar \u00e7\u00f6z\u00fcnen ya da \u00e7\u00f6z\u00fcc\u00fc kulland\u0131\u011f\u0131n\u0131za de\u011fil, yaln\u0131zca kimyasal kimliklerine ba\u011fl\u0131d\u0131r.<\/p>\n<p>\\(P\\)'nin 1'den b\u00fcy\u00fck olmas\u0131 \u00e7\u00f6z\u00fcnenin organik katman\u0131, 1'den k\u00fc\u00e7\u00fck olmas\u0131 suyu tercih etti\u011fi anlam\u0131na gelir. Ger\u00e7ek bile\u015fiklerin b\u00f6l\u00fc\u015fme katsay\u0131lar\u0131 \u00e7ok farkl\u0131 b\u00fcy\u00fckl\u00fck mertebelerine yay\u0131ld\u0131\u011f\u0131 i\u00e7in kimyac\u0131lar neredeyse her zaman \\(\\log P\\) bildirir. \u00d6rne\u011fin \\(\\log P \\approx 2\\) olan bir ila\u00e7 aday\u0131, denge h\u00e2linde suda oldu\u011fundan bin kat daha yo\u011fun bi\u00e7imde oktanolde bulunur; bu da bile\u015fi\u011fin lipid membranlar\u0131 ne kadar kolay ge\u00e7ti\u011fine dair kullan\u0131\u015fl\u0131 bir g\u00f6stergedir. Klasik referans sistemi 1-ooktanol\/su'dur ve tablolarda verilen \\(\\log P\\) de\u011ferleri, aksi belirtilmedik\u00e7e bu sisteme aittir.<\/p>\n<p>Hesaplay\u0131c\u0131n\u0131n g\u00f6sterdi\u011fi y\u00fczdeler e\u015fit faz hacimleriyle yap\u0131lan tek bir dengeyi tan\u0131mlar: yukar\u0131daki \u00f6rnekteki %80 organik \/ %20 sulu da\u011f\u0131l\u0131m gibi. Faz hacimleri farkl\u0131ysa k\u00fctle dengesi de\u011fi\u015fir \u2014 organik hacim \\(V_{org}\\) ve sulu hacim \\(V_{aq}\\) olmak \u00fczere suda kalan kesir \\(1\/(1 + P V_{org}\/V_{aq})\\) olur. S\u0131v\u0131\u2013s\u0131v\u0131 ekstraksiyonunun temeli de ayn\u0131 mant\u0131kt\u0131r: \\(P\\)'si y\u00fcksek bir \u00e7\u00f6z\u00fcnen, k\u00fc\u00e7\u00fck bir organik \u00e7\u00f6z\u00fcc\u00fc hacmine neredeyse tamamen \u00e7ekilebilir.<\/p>\n<h2>log P De\u011ferlerinin Yorumlanmas\u0131<\/h2>\n<table>\n<thead>\n<tr>\n<th>log P aral\u0131\u011f\u0131<\/th>\n<th>Tipik davran\u0131\u015f<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>&lt; \u22123<\/td>\n<td>\u00c7ok hidrofilik; \u00e7\u00f6z\u00fcnenin neredeyse tamam\u0131 suda kal\u0131r<\/td>\n<\/tr>\n<tr>\n<td>\u22123 ile 0 aras\u0131<\/td>\n<td>Hidrofilik; sulu faz\u0131 tercih eder<\/td>\n<\/tr>\n<tr>\n<td>0 ile 1 aras\u0131<\/td>\n<td>Hafif lipofilik; da\u011f\u0131l\u0131m kabaca dengededir<\/td>\n<\/tr>\n<tr>\n<td>1 ile 3 aras\u0131<\/td>\n<td>Orta derecede lipofilik; bir\u00e7ok a\u011f\u0131zdan al\u0131nan ila\u00e7 bu aral\u0131ktad\u0131r<\/td>\n<\/tr>\n<tr>\n<td>3 ile 5 aras\u0131<\/td>\n<td>Kuvvetli lipofilik; ya\u011f dokusunda ve membranlarda birikir<\/td>\n<\/tr>\n<tr>\n<td>\u2265 5<\/td>\n<td>\u00c7ok lipofilik; emilimi zay\u0131ft\u0131r, biyobirikim riski ta\u015f\u0131r<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>Varsay\u0131mlar, S\u0131n\u0131rlamalar ve Pratik \u0130pu\u00e7lar\u0131<\/h2>\n<ul>\n<li><strong>Seyreltik, ideal \u00e7\u00f6zeltiler.<\/strong> Basit oran yaln\u0131zca d\u00fc\u015f\u00fck deri\u015fimlerde sabittir; y\u00fcksek deri\u015fimlerde etkinlik etkileri g\u00f6r\u00fcn\u00fcr \\(P\\) de\u011ferinin kaymas\u0131na yol a\u00e7ar.<\/li>\n<li><strong>Yaln\u0131zca tek bir kimyasal form.<\/strong> \\(P\\), \u00e7\u00f6z\u00fcnenin her iki fazda da iyonla\u015fmad\u0131\u011f\u0131n\u0131, birle\u015fmedi\u011fini veya tepkimeye girmedi\u011fini varsayar. Sabit bir pH'da \u00f6l\u00e7\u00fclen iyonla\u015fabilir bile\u015fikler i\u00e7in bu orana da\u011f\u0131lma katsay\u0131s\u0131 \\(D\\) (log D) denir; <a href=\"https:\/\/wpcalc.com\/tr\/kimya\/henderson-hasselbalch-hesaplama\/\">Henderson\u2013Hasselbalch ba\u011f\u0131nt\u0131s\u0131<\/a> \u00fczerinden pH'a ba\u011fl\u0131d\u0131r.<\/li>\n<li><strong>Denge.<\/strong> Girilen deri\u015fimler, iyice kar\u0131\u015ft\u0131rma ve katman ayr\u0131m\u0131ndan sonra sabit bir s\u0131cakl\u0131kta \u00f6l\u00e7\u00fclm\u00fc\u015f olmal\u0131d\u0131r \u2014 \\(P\\), herhangi bir <a href=\"https:\/\/wpcalc.com\/tr\/kimya\/denge-sabiti-hesaplama\/\">denge sabiti<\/a> gibi s\u0131cakl\u0131kla de\u011fi\u015fir.<\/li>\n<li><strong>Bir b\u00fcy\u00fck ekstraksiyon yerine birka\u00e7 k\u00fc\u00e7\u00fck ekstraksiyon.<\/strong> Sulu katman \\(n\\) e\u015fit taze organik \u00e7\u00f6z\u00fcc\u00fc porsiyonuyla \u00e7alkalan\u0131rsa suda kalan \u00e7\u00f6z\u00fcnen oran\u0131 \\((1\/(1+P))^n\\) olur \u2014 s\u0131v\u0131\u2013s\u0131v\u0131 ekstraksiyonunun klasik p\u00fcf noktas\u0131d\u0131r.<\/li>\n<li><strong>Y\u00fczdeler e\u015fit hacim varsay\u0131m\u0131na dayan\u0131r.<\/strong> Bildirilen organik\/sulu y\u00fczdeleri \\(V_{org} = V_{aq}\\) varsayar; di\u011fer hacim oranlar\u0131 i\u00e7in yukar\u0131daki form\u00fclle elle d\u00fczeltin.<\/li>\n<\/ul>\n<h2>\u0130lgili Hesaplay\u0131c\u0131lar<\/h2>\n<p><a href=\"https:\/\/wpcalc.com\/en\/chemistry\/chromatography-resolution-calculator\/\">Kromatografi rezol\u00fcsyonu hesaplama arac\u0131n\u0131<\/a> ve <a href=\"https:\/\/wpcalc.com\/en\/chemistry\/thin-layer-chromatography-rf-calculator\/\">ince tabaka kromatografisi R<sub>f<\/sub> hesaplama arac\u0131n\u0131<\/a> da faydal\u0131 bulabilirsiniz \u2014 her iki teknikte de bile\u015fiklerin ayr\u0131lmas\u0131 k\u0131smen \\(P\\)'nin tan\u0131mlad\u0131\u011f\u0131 ayn\u0131 b\u00f6l\u00fc\u015fme davran\u0131\u015f\u0131na dayan\u0131r.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Bir \u00e7\u00f6z\u00fcnenin organik ve sulu fazlardaki denge deri\u015fimlerini girin; b\u00f6l\u00fc\u015fme katsay\u0131s\u0131 P, log P ve \u00e7\u00f6z\u00fcnenin her katmandaki y\u00fczdesini an\u0131nda \u00f6\u011frenin.<\/p>\n","protected":false},"author":3168,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[3],"tags":[22],"class_list":["post-3828","post","type-post","status-publish","format-standard","hentry","category-kimya","tag-biyokimya"],"acf":[],"_links":{"self":[{"href":"https:\/\/wpcalc.com\/tr\/wp-json\/wp\/v2\/posts\/3828","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wpcalc.com\/tr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wpcalc.com\/tr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wpcalc.com\/tr\/wp-json\/wp\/v2\/users\/3168"}],"replies":[{"embeddable":true,"href":"https:\/\/wpcalc.com\/tr\/wp-json\/wp\/v2\/comments?post=3828"}],"version-history":[{"count":0,"href":"https:\/\/wpcalc.com\/tr\/wp-json\/wp\/v2\/posts\/3828\/revisions"}],"wp:attachment":[{"href":"https:\/\/wpcalc.com\/tr\/wp-json\/wp\/v2\/media?parent=3828"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wpcalc.com\/tr\/wp-json\/wp\/v2\/categories?post=3828"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wpcalc.com\/tr\/wp-json\/wp\/v2\/tags?post=3828"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}