{"id":404,"date":"2026-10-03T14:08:35","date_gmt":"2026-10-03T13:08:35","guid":{"rendered":"https:\/\/wpcalc.com\/tr\/ilac-yari-omru\/"},"modified":"2026-10-03T14:08:35","modified_gmt":"2026-10-03T13:08:35","slug":"ilac-yari-omru","status":"publish","type":"post","link":"https:\/\/wpcalc.com\/tr\/tisbi\/ilac-yari-omru\/","title":{"rendered":"\u0130lac\u0131n Yar\u0131 \u00d6mr\u00fc"},"content":{"rendered":"<section class=\"not-prose calculator-box\" aria-labelledby=\"calculator-title\"><div class=\"flex items-baseline sm:items-center justify-between gap-2 sm:gap-3\"><div class=\"flex flex-col sm:flex-row sm:items-center gap-2\"><span class=\"icon icon-calculator text-primary-700! text-base! dark:text-primary-300!\" aria-hidden=\"true\"><\/span><h2 id=\"calculator-title\" class=\"text-lg font-display font-bold\">\u0130la\u00e7 Yar\u0131 \u00d6mr\u00fcn\u00fc Belirleyin<\/h2><\/div><div class=\"calcdash-favorite group\">\n  <button type=\"button\" class=\"favorite\" id=\"favorite\" data-favorite-id=\"404\" data-favorite-title=\"Yar\u0131 \u00d6m\u00fcr\" data-favorite-url=\"https:\/\/wpcalc.com\/tr\/tisbi\/ilac-yari-omru\/\" data-favorite-excerpt=\"Bir ilac\u0131n pik (tepe) deri\u015fiminden, \u00e7ukur (tal) deri\u015fiminden ve aralar\u0131ndaki s\u00fcreden yar\u0131 \u00f6mr\u00fcn\u00fc (t\u00bd) hesaplay\u0131n. \u0130lac\u0131n v\u00fccuttan at\u0131lma h\u0131z\u0131n\u0131 tahmin etmek ve doz aral\u0131klar\u0131n\u0131 se\u00e7mek i\u00e7in yararl\u0131d\u0131r.\" aria-label=\"Favorilere ekle\" data-favorite-icon=\"icon icon-pharmacology\">\n    <span class=\"icon icon-shape-star-empty\" aria-hidden=\"true\"><\/span>\n  <\/button>\n  <div class=\"calcdash-favorite__tip\" aria-hidden=\"true\">\n   <span class=\"favorite-tooltip\" id=\"favorite-tooltip\"><\/span>\n  <\/div>\n  <span class=\"sr-only\" role=\"status\" id=\"favorite-status\"><\/span>\n<\/div><\/div><form action=\"https:\/\/wpcalc.com\/tr\/tisbi\/ilac-yari-omru\/\" method=\"POST\" class=\"calculator\" id=\"calculator-404\" data-post=\"404\"><fieldset class=\"fieldset-input is-1\"><legend class=\"sr-only\">Giri\u015f alanlar\u0131<\/legend><div class=\"field has-term\" id=\"input-1\"><label for=\"field-1\">Ba\u015flang\u0131\u00e7 tepe konsantrasyonu<\/label><div class=\"term\">Ao<\/div>  <div class=\"absolute bottom-0 left-16 top-8 w-2 h-0.5 bg-blue-500\"><\/div><input type=\"number\" name=\"balang_tepe_konsantrasyonu\" id=\"field-1\" aria-describedby=\"calc-unit-1\" placeholder=\"Ba\u015flang\u0131\u00e7 konsantrasyonu\" step=\"any\" value=\"10\"\/><div class=\"unit\" id=\"calc-unit-1\">mcg\/mL<\/div><\/div><div class=\"field has-term\" id=\"input-2\"><label for=\"field-2\">S\u00fcre sonundaki vadi konsantrasyonu<\/label><div class=\"term\">Ko<\/div>  <div class=\"absolute bottom-0 left-16 top-8 w-2 h-0.5 bg-blue-500\"><\/div><input type=\"number\" name=\"sre_sonundaki_vadi_konsantrasyonu\" id=\"field-2\" aria-describedby=\"calc-unit-2\" placeholder=\"Vadi konsantrasyonu\" step=\"any\" value=\"2.5\"\/><div class=\"unit\" id=\"calc-unit-2\">mcg\/mL<\/div><\/div><div class=\"field has-term\" id=\"input-3\"><label for=\"field-3\">Zaman aral\u0131\u011f\u0131<\/label><div class=\"term\">t<\/div>  <div class=\"absolute bottom-0 left-16 top-8 w-2 h-0.5 bg-blue-500\"><\/div><input type=\"number\" name=\"zaman_aral\" id=\"field-3\" aria-describedby=\"calc-unit-3\" placeholder=\"Zaman\" step=\"any\" value=\"8\"\/><div class=\"unit\" id=\"calc-unit-3\">saat<\/div><\/div><\/fieldset><div class=\"buttons\"><button type=\"submit\" data-text=\"Yeniden hesapla\" id=\"calculate-button\" data-post=\"404\">Hesapla<\/button><button type=\"reset\">S\u0131f\u0131rla<\/button><\/div><div class=\"field is-checkbox hidden!\" id=\"field-auto-calc\"><input type=\"checkbox\" id=\"auto-calc\"><label for=\"auto-calc\">Otomatik hesapla<\/label><small>Etkinle\u015ftirilirse, herhangi bir de\u011feri de\u011fi\u015ftirdi\u011finizde sonu\u00e7 otomatik olarak g\u00fcncellenir.<\/small><\/div><div class=\"fieldset-result is-hidden\" aria-labelledby=\"result-title\" aria-live=\"polite\" role=\"region\"> <h3 class=\"result-title bg-gradient-to-r from-primary-50 to-gray-50 dark:from-primary-900 dark:to-gray-800\" id=\"result-title\"><span class=\"icon icon-s-pulse\" aria-hidden=\"true\"><\/span> Sonu\u00e7lar\u0131n\u0131z<\/h3><div class=\"result-box\"><div class=\"field-result\" id=\"output-1\"><span class=\"field-title\"><span>Yar\u0131 \u00f6m\u00fcr s\u00fcresi:<\/span><\/span><span class=\"field-value\" id=\"result-1\"><\/span><button type=\"button\" class=\"copy-result\" data-tooltip=\"Sonucu kopyala\" aria-label=\"Sonucu kopyala\"><span class=\"copy-icon icon icon-document-copy\" aria-hidden=\"true\"><\/span><\/button><\/div><\/div><div class=\"result-actions\"><button type=\"button\" class=\"copy-link\"><svg viewBox=\"0 0 20 20\" fill=\"currentColor\" aria-hidden=\"true\"><path d=\"M12.232 4.232a2.5 2.5 0 0 1 3.536 3.536l-1.225 1.224a.75.75 0 0 0 1.061 1.06l1.224-1.224a4 4 0 0 0-5.656-5.656l-3 3a4 4 0 0 0 .225 5.865.75.75 0 0 0 .977-1.138 2.5 2.5 0 0 1-.142-3.667l3-3Z\"\/><path d=\"M11.603 7.963a.75.75 0 0 0-.977 1.138 2.5 2.5 0 0 1 .142 3.667l-3 3a2.5 2.5 0 0 1-3.536-3.536l1.225-1.224a.75.75 0 0 0-1.061-1.06l-1.224 1.224a4 4 0 1 0 5.656 5.656l3-3a4 4 0 0 0-.225-5.865Z\"\/><\/svg><span class=\"copy-link__text\">Bu hesaplaman\u0131n ba\u011flant\u0131s\u0131n\u0131 kopyala<\/span><\/button><span class=\"sr-only\" role=\"status\" id=\"copy-link-status\"><\/span><\/div><\/div><a href=\"#respond\" class=\"hidden transition-opacity duration-300 opacity-0 w-50 text-sm justify-center items-center gap-2 px-4 py-2 rounded bg-gray-200 text-gray-700 hover:bg-gray-300\" id=\"leave-comment\"><span class=\"icon icon-comments\" aria-hidden=\"true\"><\/span>Yorum b\u0131rak<\/a><\/form><\/section><section id=\"calc-reactions\" class=\"not-prose hidden my-12 bg-gradient-to-r from-primary-50 to-gray-50 border border-indigo-100 rounded-xl px-6 py-4 shadow-sm\" data-post=\"404\" aria-live=\"polite\" aria-labelledby=\"calc-reactions-title\"><p id=\"calc-reactions-title\" class=\"text-sm text-gray-500 text-center mb-2\">Bu sonu\u00e7 hakk\u0131nda ne d\u00fc\u015f\u00fcn\u00fcyorsunuz?<\/p><div role=\"group\" aria-labelledby=\"calc-reactions-title\" class=\"grid grid-cols-3 sm:flex sm:flex-row sm:justify-around gap-4 sm:items-center sm:flex-wrap\"><button type=\"button\" aria-pressed=\"false\" class=\"reaction-btn flex flex-col items-center gap-1 text-sm text-gray-700 hover:text-primary-600 cursor-pointer transition-transform hover:scale-105\" data-reaction=\"like\"><span class=\"reaction-count\" data-reaction-count=\"like\">0<\/span><span class=\"reaction text-3xl\" aria-hidden=\"true\">\ud83d\ude00 <\/span><span class=\"reaction-description font-medium\">Be\u011fendim <\/span><\/button><button type=\"button\" aria-pressed=\"false\" class=\"reaction-btn flex flex-col items-center gap-1 text-sm text-gray-700 hover:text-primary-600 cursor-pointer transition-transform hover:scale-105\" data-reaction=\"helpful\"><span class=\"reaction-count\" data-reaction-count=\"helpful\">0<\/span><span class=\"reaction text-3xl\" aria-hidden=\"true\">\ud83d\udca1 <\/span><span class=\"reaction-description font-medium\">Faydal\u0131 <\/span><\/button><button type=\"button\" aria-pressed=\"false\" class=\"reaction-btn flex flex-col items-center gap-1 text-sm text-gray-700 hover:text-primary-600 cursor-pointer transition-transform hover:scale-105\" data-reaction=\"confused\"><span class=\"reaction-count\" data-reaction-count=\"confused\">0<\/span><span class=\"reaction text-3xl\" aria-hidden=\"true\">\ud83d\ude15 <\/span><span class=\"reaction-description font-medium\">Kafam kar\u0131\u015ft\u0131 <\/span><\/button><button type=\"button\" aria-pressed=\"false\" class=\"reaction-btn flex flex-col items-center gap-1 text-sm text-gray-700 hover:text-primary-600 cursor-pointer transition-transform hover:scale-105\" data-reaction=\"disappointed\"><span class=\"reaction-count\" data-reaction-count=\"disappointed\">0<\/span><span class=\"reaction text-3xl\" aria-hidden=\"true\">\ud83d\ude1e <\/span><span class=\"reaction-description font-medium\">Hayal k\u0131r\u0131kl\u0131\u011f\u0131 <\/span><\/button><button type=\"button\" aria-pressed=\"false\" class=\"reaction-btn flex flex-col items-center gap-1 text-sm text-gray-700 hover:text-primary-600 cursor-pointer transition-transform hover:scale-105\" data-reaction=\"inaccurate\"><span class=\"reaction-count\" data-reaction-count=\"inaccurate\">0<\/span><span class=\"reaction text-3xl\" aria-hidden=\"true\">\u274c <\/span><span class=\"reaction-description font-medium\">Hatal\u0131 <\/span><\/button><\/div><div id=\"reaction-message\" class=\"hidden mt-8 rounded-md border border-primary-100 bg-white\/50 backdrop-blur-sm px-4 py-2 text-sm text-center shadow-sm\"><\/div><\/section><div class=\"calcdash-ad not-prose calcdash-ad--calc_result calcdash-ad--in-article\"><ins class=\"adsbygoogle\" style=\"display:block\" data-ad-client=\"ca-pub-1721569815777345\" data-ad-slot=\"6317458308\" data-ad-layout=\"in-article\" data-ad-format=\"fluid\"><\/ins><script>(adsbygoogle = window.adsbygoogle || []).push({});<\/script><\/div>\n<style id=\"wpcoderpro-inline-1\">.formula-box {\r\n\tborder-bottom: none !important;\r\n}<\/style><section class=\"formula-box\" aria-labelledby=\"formula-title\">\r\n\t<div id=\"formula-title\" class=\"not-prose font-display mb-4\"><span class=\"icon icon-formula\" aria-hidden=\"true\"><\/span><h2>Yar\u0131 \u00d6m\u00fcr Form\u00fcl\u00fc<\/h2><\/div>\r\n\t<figure class=\"not-prose formula\">\r\n\t\t<figcaption class=\"formula-title\">Form\u00fcl<\/figcaption>\r\n\t\t<div class=\"text-base text-gray-800\" id=\"formula\">\n\\[ k = \\frac{\\ln(A_0 \/ K_0)}{t} \\\\ t_{1\/2} = \\frac{\\ln 2}{k} = \\frac{0.693 \\times t}{\\ln(A_0 \/ K_0)} \\]\n<\/div>\r\n\t<\/figure>\r\n\t<\/p>\n<p><strong>Burada:<\/strong><\/p>\n<ul>\n<li>\\(t_{1\/2}\\) \u2014 yar\u0131 \u00f6m\u00fcr (saat), deri\u015fimin %50 azalmas\u0131 i\u00e7in gereken s\u00fcre<\/li>\n<li>\\(A_0\\) \u2014 ba\u015flang\u0131\u00e7 pik deri\u015fimi (mcg\/mL)<\/li>\n<li>\\(K_0\\) \u2014 \\(t\\) s\u00fcresinden sonra \u00f6l\u00e7\u00fclen \u00e7ukur deri\u015fim (mcg\/mL)<\/li>\n<li>\\(t\\) \u2014 iki \u00f6l\u00e7\u00fcm aras\u0131ndaki zaman aral\u0131\u011f\u0131 (saat)<\/li>\n<li>\\(k\\) \u2014 eliminasyon h\u0131z sabitesi (1\/saat)<\/li>\n<\/ul>\n<p>Form\u00fcl birinci mertebe (first-order) eliminasyon varsayar: deri\u015fim \u00fcstel olarak azal\u0131r, dolay\u0131s\u0131yla \\(k\\) iki \u00f6l\u00e7\u00fclen deri\u015fimin oran\u0131ndan bulunur ve yar\u0131 \u00f6m\u00fcr \\(\\ln 2 \\approx 0.693\\) de\u011ferinden hesaplan\u0131r.<\/p>\n<p>\r\n<\/section>\n<style id=\"wpcoderpro-inline-2\">.calculation-box {\r\n\tborder-bottom: none !important;\r\n}<\/style><section id=\"calculation\" class=\"calculation-box\" aria-labelledby=\"calculation-title\">\r\n\t<div id=\"calculation-title\" class=\"not-prose font-display\"><span class=\"icon icon-unordered-list\" aria-hidden=\"true\"><\/span><h2>Yar\u0131 \u00d6m\u00fcr \u2013 Hesaplama \u00d6rne\u011fi<\/h2><\/div>\r\n\r\n<\/p>\n<p><strong>\u00d6rnek:<\/strong> bir ilac\u0131n pik deri\u015fimi 10 mcg\/mL'ye ula\u015f\u0131yor ve 8 saat sonra deri\u015fimi 2,5 mcg\/mL'ye d\u00fc\u015f\u00fcyor.<\/p>\n<p>\\[ k = \\frac{\\ln(10 \/ 2.5)}{8} = \\frac{\\ln 4}{8} = \\frac{1.3863}{8} = 0.1733 \\ \\text{saat}^{-1} \\]<\/p>\n<p>\\[ t_{1\/2} = \\frac{0.693}{0.1733} = 4 \\ \\text{saat} \\]<\/p>\n<p><strong>Sonu\u00e7:<\/strong> yar\u0131 \u00f6m\u00fcr 4 saattir \u2014 her 4 saatte bir deri\u015fim yar\u0131ya d\u00fc\u015fer (10'dan 5'e, oradan 2,5 mcg\/mL'ye; bu, \u00f6l\u00e7\u00fclen \u00e7ukur deri\u015fimiyle de uyu\u015fur).<\/p>\n<p>\n\r\n<\/section>\n<h2>Hesaplay\u0131c\u0131 Nas\u0131l Kullan\u0131l\u0131r?<\/h2>\n<ol>\n<li><strong>Ba\u015flang\u0131\u00e7 pik deri\u015fimini<\/strong> mcg\/mL cinsinden girin \u2014 iki \u00f6l\u00e7\u00fclen deri\u015fimden y\u00fcksek olan\u0131 (\u00f6rne\u011fin doz sonras\u0131 al\u0131nan pik d\u00fczeyi).<\/li>\n<li><strong>S\u00fcre sonras\u0131ndaki \u00e7ukur deri\u015fimini<\/strong> mcg\/mL cinsinden girin \u2014 daha sonra, bir sonraki dozdan hemen \u00f6nce \u00f6l\u00e7\u00fclen daha d\u00fc\u015f\u00fck deri\u015fim.<\/li>\n<li>\u0130ki \u00f6l\u00e7\u00fcm aras\u0131ndaki <strong>zaman aral\u0131\u011f\u0131n\u0131<\/strong> saat cinsinden girin.<\/li>\n<li>Saat cinsinden <strong>Yar\u0131 \u00f6m\u00fcr<\/strong> de\u011ferini okuyun; bu de\u011fer, ila\u00e7 deri\u015fiminin yar\u0131ya inmesi i\u00e7in ne kadar s\u00fcre ge\u00e7mesi gerekti\u011fini g\u00f6sterir.<\/li>\n<\/ol>\n<h2>\u0130lac\u0131n Yar\u0131 \u00d6mr\u00fc Nedir?<\/h2>\n<p>Bir ilac\u0131n \\(t_{1\/2}\\) yar\u0131 \u00f6mr\u00fc, kandaki (veya plazmadaki) deri\u015fiminin yar\u0131ya azalmas\u0131 i\u00e7in gereken s\u00fcredir. \u00c7o\u011fu ila\u00e7ta eliminasyon <em>birinci mertebe kinetik<\/em> ile ger\u00e7ekle\u015fir: birim zamanda ilac\u0131n sabit bir <em>kesri<\/em> temizlenir, dolay\u0131s\u0131yla deri\u015fim d\u00fcz bir \u00e7izgi de\u011fil \u00fcstel bir e\u011fri boyunca d\u00fc\u015fer. Yar\u0131 \u00f6m\u00fcr, bu azalman\u0131n ne kadar h\u0131zl\u0131 oldu\u011funu anlatman\u0131n en do\u011fal yoludur.<\/p>\n<p>Yar\u0131 \u00f6m\u00fcr do\u011frudan dozlama kararlar\u0131n\u0131 belirler. Yar\u0131 \u00f6mr\u00fc 4 saat olan bir ila\u00e7, 16 saat sonra (d\u00f6rt yar\u0131 \u00f6m\u00fcr) bir dozun yakla\u015f\u0131k %94'\u00fcn\u00fc kaybeder; bu nedenle genellikle d\u00fczeyleri terap\u00f6tik aral\u0131kta tutmak i\u00e7in g\u00fcnde \u00fc\u00e7 veya d\u00f6rt kez dozlanmas\u0131 gerekir. Yar\u0131 \u00f6mr\u00fc 24 saat veya daha uzun olan bir ila\u00e7 ise \u00e7o\u011fu zaman g\u00fcnde bir kez verilebilir. Yar\u0131 \u00f6m\u00fcr ayr\u0131ca <em>birikim<\/em> s\u00fcresini de belirler: yakla\u015f\u0131k 4\u20135 yar\u0131 \u00f6m\u00fcrl\u00fck tekrarlanan dozlama sonras\u0131nda ila\u00e7 kararl\u0131 duruma (steady state) ula\u015f\u0131r ve ayn\u0131 kural, ila\u00e7 kesildikten sonraki at\u0131l\u0131m (washout) i\u00e7in de ge\u00e7erlidir.<\/p>\n<p>Bu hesaplay\u0131c\u0131, yar\u0131 \u00f6mr\u00fc iki ger\u00e7ek \u00f6l\u00e7\u00fcmden \u2014 aralar\u0131ndaki s\u00fcre bilinen bir pik ve bir \u00e7ukur deri\u015fimden \u2014 tahmin eder. Klinik\u00e7iler dar terap\u00f6tik penceresi olan ila\u00e7lar i\u00e7in, \u00f6rne\u011fin vankomisin veya aminoglikozitler gibi d\u00fczeylerinin izlendi\u011fi ve dozlar\u0131n\u0131n ayarland\u0131\u011f\u0131 ila\u00e7lar i\u00e7in tam olarak b\u00f6yle d\u00fc\u015f\u00fcn\u00fcr. \\(t_{1\/2}\\) de\u011ferini bildikten sonra herhangi bir gelecekteki andaki deri\u015fimi \u00f6ng\u00f6rebilir ya da uygun bir doz aral\u0131\u011f\u0131na geriye do\u011fru hesap yapabilirsiniz. \u0130nf\u00fczyon h\u0131z\u0131n\u0131n kendisini planlamak i\u00e7in <a href=\"https:\/\/wpcalc.com\/tr\/tisbi\/doz-infuzyon-hizi\/\">Doz \u0130nf\u00fczyonu hesaplay\u0131c\u0131s\u0131na<\/a>, a\u011f\u0131rl\u0131\u011fa dayal\u0131 tablet dozlamas\u0131 i\u00e7in ise <a href=\"https:\/\/wpcalc.com\/tr\/tisbi\/tablet-doz-hesaplama\/\">Tablet Dozu hesaplay\u0131c\u0131s\u0131na<\/a> bak\u0131n.<\/p>\n<h2>Sonucun Yorumlanmas\u0131<\/h2>\n<ul>\n<li><strong>K\u0131sa yar\u0131 \u00f6m\u00fcr (yakla\u015f\u0131k 6 saatin alt\u0131):<\/strong> h\u0131zl\u0131 at\u0131l\u0131m; s\u0131k dozlama veya uzat\u0131lm\u0131\u015f sal\u0131ml\u0131 (extended-release) bir form\u00fclasyon genellikle gerekir.<\/li>\n<li><strong>Uzun yar\u0131 \u00f6m\u00fcr (yakla\u015f\u0131k 24 saatin \u00fcst\u00fc):<\/strong> yava\u015f at\u0131l\u0131m; g\u00fcnde tek doz yeterli olabilir, ancak birikim ve gecikmi\u015f at\u0131l\u0131m dikkat gerektirir.<\/li>\n<li><strong>\\(n\\) yar\u0131 \u00f6m\u00fcr sonras\u0131 deri\u015fim:<\/strong> kalan kesir \\( (1\/2)^n \\) kadard\u0131r \u2014 \u00f6rne\u011fin 2 yar\u0131 \u00f6m\u00fcr sonra %25, 4 yar\u0131 \u00f6m\u00fcr sonra %6,25.<\/li>\n<\/ul>\n<h2>Varsay\u0131mlar ve S\u0131n\u0131rl\u0131l\u0131klar<\/h2>\n<ul>\n<li>Hesaplama <strong>birinci mertebe eliminasyon<\/strong> (\u00fcstel azalma) varsayar. Baz\u0131 ila\u00e7lar \u2014 etanol, y\u00fcksek d\u00fczeylerde fenitoin, toksik dozlarda aspirin \u2014 s\u0131f\u0131r\u0131nc\u0131 mertebe (sabit h\u0131zl\u0131) kinetik izler; bunlar i\u00e7in yar\u0131 \u00f6m\u00fcr tan\u0131ml\u0131 de\u011fildir ve bu form\u00fcl uygulanamaz.<\/li>\n<li>\u0130ki \u00f6l\u00e7\u00fcm aras\u0131nda ba\u015fka bir emilimin olmad\u0131\u011f\u0131 varsayar; \u00e7ukur deri\u015fim, d\u00fczeyler d\u00fc\u015ferken al\u0131nmal\u0131d\u0131r, ila\u00e7 h\u00e2l\u00e2 emilirken veya da\u011f\u0131l\u0131rken de\u011fil.<\/li>\n<li>Yar\u0131 \u00f6m\u00fcr hem <strong>klirens hem de da\u011f\u0131l\u0131m hacmine<\/strong> ba\u011fl\u0131d\u0131r. B\u00f6brek veya karaci\u011fer yetmezli\u011fi, kalp yetmezli\u011fi veya dehidratasyon durumunda yar\u0131 \u00f6m\u00fcr sa\u011fl\u0131kl\u0131 bir hastaya g\u00f6re \u00e7ok daha uzun olabilir \u2014 \u00f6l\u00e7\u00fclen d\u00fczeyler, kitap de\u011ferlerinden daha g\u00fcvenilirdir. B\u00f6brek i\u015fleviyle ilgili doz ayarlamalar\u0131 i\u00e7in <a href=\"https:\/\/wpcalc.com\/tr\/tisbi\/diyaliz-dozu\/\">Diyaliz Dozu (Kt\/V) hesaplay\u0131c\u0131s\u0131<\/a> yararl\u0131 olabilir.<\/li>\n<li>Her iki deri\u015fim de ayn\u0131 birimde olmal\u0131d\u0131r ve \u00e7ukur deri\u015fim pikten d\u00fc\u015f\u00fck olmal\u0131d\u0131r; aksi halde eliminasyon sabitesi \\(k\\) negatif veya tan\u0131ms\u0131z olur.<\/li>\n<li>Bu arac\u0131 e\u011fitim ve tahmin amac\u0131yla kullan\u0131n; bir eczac\u0131 veya hekim g\u00f6zetimindeki terap\u00f6tik ila\u00e7 izlemisinin yerine ge\u00e7mez.<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>Bir ilac\u0131n pik (tepe) deri\u015fiminden, \u00e7ukur (tal) deri\u015fiminden ve aralar\u0131ndaki s\u00fcreden yar\u0131 \u00f6mr\u00fcn\u00fc (t\u00bd) hesaplay\u0131n. \u0130lac\u0131n v\u00fccuttan at\u0131lma h\u0131z\u0131n\u0131 tahmin etmek ve doz aral\u0131klar\u0131n\u0131 se\u00e7mek i\u00e7in yararl\u0131d\u0131r.<\/p>\n","protected":false},"author":3168,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[11],"tags":[60],"class_list":["post-404","post","type-post","status-publish","format-standard","hentry","category-tisbi","tag-farmakoloji"],"acf":[],"_links":{"self":[{"href":"https:\/\/wpcalc.com\/tr\/wp-json\/wp\/v2\/posts\/404","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wpcalc.com\/tr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wpcalc.com\/tr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wpcalc.com\/tr\/wp-json\/wp\/v2\/users\/3168"}],"replies":[{"embeddable":true,"href":"https:\/\/wpcalc.com\/tr\/wp-json\/wp\/v2\/comments?post=404"}],"version-history":[{"count":4,"href":"https:\/\/wpcalc.com\/tr\/wp-json\/wp\/v2\/posts\/404\/revisions"}],"predecessor-version":[{"id":2888,"href":"https:\/\/wpcalc.com\/tr\/wp-json\/wp\/v2\/posts\/404\/revisions\/2888"}],"wp:attachment":[{"href":"https:\/\/wpcalc.com\/tr\/wp-json\/wp\/v2\/media?parent=404"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wpcalc.com\/tr\/wp-json\/wp\/v2\/categories?post=404"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wpcalc.com\/tr\/wp-json\/wp\/v2\/tags?post=404"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}