{"id":4162,"date":"2026-11-02T09:53:59","date_gmt":"2026-11-02T09:53:59","guid":{"rendered":"https:\/\/wpcalc.com\/tr\/tisbi\/kortikosteroid-donusum-hesaplayici\/"},"modified":"2026-11-02T09:53:59","modified_gmt":"2026-11-02T09:53:59","slug":"kortikosteroid-donusum-hesaplayici","status":"publish","type":"post","link":"https:\/\/wpcalc.com\/tr\/tisbi\/kortikosteroid-donusum-hesaplayici\/","title":{"rendered":"Kortikosteroid D\u00f6n\u00fc\u015f\u00fcm Hesaplay\u0131c\u0131s\u0131"},"content":{"rendered":"<section class=\"not-prose calculator-box\" aria-labelledby=\"calculator-title\"><div class=\"flex items-baseline sm:items-center justify-between gap-2 sm:gap-3\"><div class=\"flex flex-col sm:flex-row sm:items-center gap-2\"><span class=\"icon icon-calculator text-primary-700! text-base! dark:text-primary-300!\" aria-hidden=\"true\"><\/span><h2 id=\"calculator-title\" class=\"text-lg font-display font-bold\">Sistemik kortikosteroidler aras\u0131nda doz d\u00f6n\u00fc\u015f\u00fcm\u00fc<\/h2><\/div><div class=\"calcdash-favorite group\">\n  <button type=\"button\" class=\"favorite\" id=\"favorite\" data-favorite-id=\"4162\" data-favorite-title=\"Kortikosteroid d\u00f6n\u00fc\u015f\u00fcm\u00fc\" data-favorite-url=\"https:\/\/wpcalc.com\/tr\/tisbi\/kortikosteroid-donusum-hesaplayici\/\" data-favorite-excerpt=\"Sistemik kortikosteroidler aras\u0131ndaki (prednizon, deksametazon, hidrokortizon vb.) doz d\u00f6n\u00fc\u015f\u00fcm\u00fc yap\u0131n. \u0130la\u00e7 ve doz girin; prednizon e\u015fde\u011feri dozu ile etki g\u00fcc\u00fc ve yar\u0131 \u00f6m\u00fcr\u00fc i\u00e7eren tam d\u00f6n\u00fc\u015f\u00fcm tablosunu g\u00f6r\u00fcn.\" aria-label=\"Favorilere ekle\" data-favorite-icon=\"icon icon-pharmacology\">\n    <span class=\"icon icon-shape-star-empty\" aria-hidden=\"true\"><\/span>\n  <\/button>\n  <div class=\"calcdash-favorite__tip\" aria-hidden=\"true\">\n   <span class=\"favorite-tooltip\" id=\"favorite-tooltip\"><\/span>\n  <\/div>\n  <span class=\"sr-only\" role=\"status\" id=\"favorite-status\"><\/span>\n<\/div><\/div><form action=\"https:\/\/wpcalc.com\/tr\/tisbi\/kortikosteroid-donusum-hesaplayici\/\" method=\"POST\" class=\"calculator\" id=\"calculator-4162\" data-post=\"4162\"><fieldset class=\"fieldset-input is-2\"><legend class=\"sr-only\">Giri\u015f alanlar\u0131<\/legend><div class=\"field is-single\" id=\"input-1\"><label for=\"field-1\">\u0130la\u00e7<\/label><div class=\"grid grid-cols-1\"><select id=\"field-1\" name=\"la\"><option value=\"hydrocortisone\">Hidrokortizon<\/option><option value=\"cortisone\">Kortizon<\/option><option value=\"prednisone\" selected>Prednizon<\/option><option value=\"prednisolone\">Prednizolon<\/option><option value=\"methylprednisolone\">Metilprednizolon<\/option><option value=\"triamcinolone\">Triamsinolon<\/option><option value=\"dexamethasone\">Deksametazon<\/option><option value=\"betamethasone\">Betametazon<\/option><\/select><svg class=\"pointer-events-none col-start-1 row-start-1 mr-2 size-5 self-center justify-self-end text-gray-500 sm:size-4\" viewBox=\"0 0 16 16\" fill=\"currentColor\" aria-hidden=\"true\" data-slot=\"icon\">\n              <path fill-rule=\"evenodd\" d=\"M4.22 6.22a.75.75 0 0 1 1.06 0L8 8.94l2.72-2.72a.75.75 0 1 1 1.06 1.06l-3.25 3.25a.75.75 0 0 1-1.06 0L4.22 7.28a.75.75 0 0 1 0-1.06Z\" clip-rule=\"evenodd\" \/>\n            <\/svg><\/div><\/div><div class=\"field has-term\" id=\"input-2\"><label for=\"field-2\">Doz<\/label><div class=\"term\">mg<\/div>  <div class=\"absolute bottom-0 left-16 top-8 w-2 h-0.5 bg-blue-500\"><\/div><input type=\"text\" name=\"doz\" id=\"field-2\" aria-describedby=\"calc-unit-2 calc-info-2\" data-number inputmode=\"decimal\" autocomplete=\"off\" spellcheck=\"false\" min=\"0.01\" max=\"100000\" value=\"30\"\/><div class=\"unit\" id=\"calc-unit-2\">mg<\/div><small id=\"calc-info-2\">Yukar\u0131da se\u00e7ilen ilac\u0131n g\u00fcnl\u00fck veya tek dozdaki miktar\u0131. E\u015fde\u011ferlik tek doz ba\u015f\u0131na miktar i\u00e7in ge\u00e7erlidir; g\u00fcnl\u00fck toplam i\u00e7in dozu, g\u00fcn i\u00e7indeki doz say\u0131s\u0131yla \u00e7arp\u0131n.<\/small><\/div><\/fieldset><div class=\"buttons\"><button type=\"submit\" data-text=\"Yeniden hesapla\" id=\"calculate-button\" data-post=\"4162\">Hesapla<\/button><button type=\"reset\">S\u0131f\u0131rla<\/button><\/div><div class=\"field is-checkbox hidden!\" id=\"field-auto-calc\"><input type=\"checkbox\" id=\"auto-calc\"><label for=\"auto-calc\">Otomatik hesapla<\/label><small>Etkinle\u015ftirilirse, herhangi bir de\u011feri de\u011fi\u015ftirdi\u011finizde sonu\u00e7 otomatik olarak g\u00fcncellenir.<\/small><\/div><div class=\"fieldset-result is-hidden\" aria-labelledby=\"result-title\" aria-live=\"polite\" role=\"region\"> <h3 class=\"result-title bg-gradient-to-r from-primary-50 to-gray-50 dark:from-primary-900 dark:to-gray-800\" id=\"result-title\"><span class=\"icon icon-s-pulse\" aria-hidden=\"true\"><\/span> E\u015fde\u011fer dozlar<\/h3><div class=\"result-box\"><div class=\"field-result\" id=\"output-1\"><span class=\"field-title\"><span>E\u015fde\u011fer prednizon dozu<\/span><span class=\"result-term\">e\u015fd<\/span><\/span><span class=\"field-value\" id=\"result-1\" data-unit=\"mg\"><\/span><button type=\"button\" class=\"copy-result\" data-tooltip=\"Sonucu kopyala\" aria-label=\"Sonucu kopyala\"><span class=\"copy-icon icon icon-document-copy\" aria-hidden=\"true\"><\/span><\/button><\/div><div class=\"field-result is-column\" id=\"output-2\"><span class=\"field-title\"><span>E\u015fde\u011fer dozlar, etki g\u00fcc\u00fc ve yar\u0131lanma \u00f6mr\u00fc<\/span><\/span><span class=\"field-value\" id=\"result-2\"><\/span><button type=\"button\" class=\"copy-result\" data-tooltip=\"Sonucu kopyala\" aria-label=\"Sonucu kopyala\"><span class=\"copy-icon icon icon-document-copy\" aria-hidden=\"true\"><\/span><\/button><\/div><div class=\"field-result is-column\" id=\"output-3\"><span class=\"field-title\"><span>D\u00f6n\u00fc\u015f\u00fcm notlar\u0131 ve yasal uyar\u0131<\/span><\/span><span class=\"field-value\" id=\"result-3\"><\/span><button type=\"button\" class=\"copy-result\" data-tooltip=\"Sonucu kopyala\" aria-label=\"Sonucu kopyala\"><span class=\"copy-icon icon icon-document-copy\" aria-hidden=\"true\"><\/span><\/button><\/div><\/div><div class=\"result-actions\"><button type=\"button\" class=\"copy-link\"><svg viewBox=\"0 0 20 20\" fill=\"currentColor\" aria-hidden=\"true\"><path d=\"M12.232 4.232a2.5 2.5 0 0 1 3.536 3.536l-1.225 1.224a.75.75 0 0 0 1.061 1.06l1.224-1.224a4 4 0 0 0-5.656-5.656l-3 3a4 4 0 0 0 .225 5.865.75.75 0 0 0 .977-1.138 2.5 2.5 0 0 1-.142-3.667l3-3Z\"\/><path d=\"M11.603 7.963a.75.75 0 0 0-.977 1.138 2.5 2.5 0 0 1 .142 3.667l-3 3a2.5 2.5 0 0 1-3.536-3.536l1.225-1.224a.75.75 0 0 0-1.061-1.06l-1.224 1.224a4 4 0 1 0 5.656 5.656l3-3a4 4 0 0 0-.225-5.865Z\"\/><\/svg><span class=\"copy-link__text\">Bu hesaplaman\u0131n ba\u011flant\u0131s\u0131n\u0131 kopyala<\/span><\/button><span class=\"sr-only\" role=\"status\" id=\"copy-link-status\"><\/span><\/div><\/div><a href=\"#respond\" class=\"hidden transition-opacity duration-300 opacity-0 w-50 text-sm justify-center items-center gap-2 px-4 py-2 rounded bg-gray-200 text-gray-700 hover:bg-gray-300\" id=\"leave-comment\"><span class=\"icon icon-comments\" aria-hidden=\"true\"><\/span>Yorum b\u0131rak<\/a><\/form><\/section><section id=\"calc-reactions\" class=\"not-prose hidden my-12 bg-gradient-to-r from-primary-50 to-gray-50 border border-indigo-100 rounded-xl px-6 py-4 shadow-sm\" data-post=\"4162\" aria-live=\"polite\" aria-labelledby=\"calc-reactions-title\"><p id=\"calc-reactions-title\" class=\"text-sm text-gray-500 text-center mb-2\">Bu sonu\u00e7 hakk\u0131nda ne d\u00fc\u015f\u00fcn\u00fcyorsunuz?<\/p><div role=\"group\" aria-labelledby=\"calc-reactions-title\" class=\"grid grid-cols-3 sm:flex sm:flex-row sm:justify-around gap-4 sm:items-center sm:flex-wrap\"><button type=\"button\" aria-pressed=\"false\" class=\"reaction-btn flex flex-col items-center gap-1 text-sm text-gray-700 hover:text-primary-600 cursor-pointer transition-transform hover:scale-105\" data-reaction=\"like\"><span class=\"reaction-count\" data-reaction-count=\"like\">0<\/span><span class=\"reaction text-3xl\" aria-hidden=\"true\">\ud83d\ude00 <\/span><span class=\"reaction-description font-medium\">Be\u011fendim <\/span><\/button><button type=\"button\" aria-pressed=\"false\" class=\"reaction-btn flex flex-col items-center gap-1 text-sm text-gray-700 hover:text-primary-600 cursor-pointer transition-transform hover:scale-105\" data-reaction=\"helpful\"><span class=\"reaction-count\" data-reaction-count=\"helpful\">0<\/span><span class=\"reaction text-3xl\" aria-hidden=\"true\">\ud83d\udca1 <\/span><span class=\"reaction-description font-medium\">Faydal\u0131 <\/span><\/button><button type=\"button\" aria-pressed=\"false\" class=\"reaction-btn flex flex-col items-center gap-1 text-sm text-gray-700 hover:text-primary-600 cursor-pointer transition-transform hover:scale-105\" data-reaction=\"confused\"><span class=\"reaction-count\" data-reaction-count=\"confused\">0<\/span><span class=\"reaction text-3xl\" aria-hidden=\"true\">\ud83d\ude15 <\/span><span class=\"reaction-description font-medium\">Kafam kar\u0131\u015ft\u0131 <\/span><\/button><button type=\"button\" aria-pressed=\"false\" class=\"reaction-btn flex flex-col items-center gap-1 text-sm text-gray-700 hover:text-primary-600 cursor-pointer transition-transform hover:scale-105\" data-reaction=\"disappointed\"><span class=\"reaction-count\" data-reaction-count=\"disappointed\">0<\/span><span class=\"reaction text-3xl\" aria-hidden=\"true\">\ud83d\ude1e <\/span><span class=\"reaction-description font-medium\">Hayal k\u0131r\u0131kl\u0131\u011f\u0131 <\/span><\/button><button type=\"button\" aria-pressed=\"false\" class=\"reaction-btn flex flex-col items-center gap-1 text-sm text-gray-700 hover:text-primary-600 cursor-pointer transition-transform hover:scale-105\" data-reaction=\"inaccurate\"><span class=\"reaction-count\" data-reaction-count=\"inaccurate\">0<\/span><span class=\"reaction text-3xl\" aria-hidden=\"true\">\u274c <\/span><span class=\"reaction-description font-medium\">Hatal\u0131 <\/span><\/button><\/div><div id=\"reaction-message\" class=\"hidden mt-8 rounded-md border border-primary-100 bg-white\/50 backdrop-blur-sm px-4 py-2 text-sm text-center shadow-sm\"><\/div><\/section><div class=\"calcdash-ad not-prose calcdash-ad--calc_result calcdash-ad--in-article\"><ins class=\"adsbygoogle\" style=\"display:block\" data-ad-client=\"ca-pub-1721569815777345\" data-ad-slot=\"6317458308\" data-ad-layout=\"in-article\" data-ad-format=\"fluid\"><\/ins><script>(adsbygoogle = window.adsbygoogle || []).push({});<\/script><\/div>\n<style id=\"wpcoderpro-inline-1\">.formula-box {\r\n\tborder-bottom: none !important;\r\n}<\/style><section class=\"formula-box\" aria-labelledby=\"formula-title\">\r\n\t<div id=\"formula-title\" class=\"not-prose font-display mb-4\"><span class=\"icon icon-formula\" aria-hidden=\"true\"><\/span><h2>Kortikosteroid d\u00f6n\u00fc\u015f\u00fcm form\u00fcl\u00fc<\/h2><\/div>\r\n\t<figure class=\"not-prose formula\">\r\n\t\t<figcaption class=\"formula-title\">Form\u00fcl<\/figcaption>\r\n\t\t<div class=\"text-base text-gray-800\" id=\"formula\">\n\\[ D_{\\text{prednizon}} = D_{\\text{girilen}} \\times \\frac{5}{B_{\\text{girilen}}} \\]\n\\[ D_{\\text{hedef}} = D_{\\text{prednizon}} \\times \\frac{B_{\\text{hedef}}}{5} = D_{\\text{girilen}} \\times \\frac{B_{\\text{hedef}}}{B_{\\text{girilen}}} \\]\n<\/div>\r\n\t<\/figure>\r\n\t<\/p>\n<p><strong>Buradaki g\u00f6sterimler:<\/strong><\/p>\n<ul>\n<li>\\(D_{\\text{girilen}}\\) \u2014 d\u00f6n\u00fc\u015f\u00fcm\u00fc yap\u0131lan ilac\u0131n dozu (mg)<\/li>\n<li>\\(B_{\\text{girilen}}\\), \\(B_{\\text{hedef}}\\) \u2014 her ilac\u0131n prednizon 5 mg'a denk gelen temel dozu (hidrokortizon 20 mg, kortizon 25 mg, prednizon\/prednizolon 5 mg, metilprednizolon\/triamsinolon 4 mg, deksametazon 0,75 mg, betametazon 0,6 mg)<\/li>\n<li>\\(D_{\\text{prednizon}}\\) \u2014 prednizon cinsinden ifade edilen e\u015fde\u011fer miktar (mg)<\/li>\n<\/ul>\n<p>Form\u00fcl, her temel dozun prednizon 5 mg'a e\u015fit oldu\u011fu standart etki g\u00fcc\u00fc tablosunu kullanarak herhangi bir sistemik kortikosteroid dozunu, istenen ba\u015fka bir ilac\u0131n antiinflamatuar e\u015fde\u011ferine d\u00f6n\u00fc\u015ft\u00fcr\u00fcr.<\/p>\n<p>\r\n<\/section>\n<style id=\"wpcoderpro-inline-2\">.calculation-box {\r\n\tborder-bottom: none !important;\r\n}<\/style><section id=\"calculation\" class=\"calculation-box\" aria-labelledby=\"calculation-title\">\r\n\t<div id=\"calculation-title\" class=\"not-prose font-display\"><span class=\"icon icon-unordered-list\" aria-hidden=\"true\"><\/span><h2>Kortikosteroid d\u00f6n\u00fc\u015f\u00fcm\u00fc \u2013 hesaplama \u00f6rne\u011fi<\/h2><\/div>\r\n\r\n<\/p>\n<p><strong>\u00d6rnek:<\/strong> bir hasta g\u00fcnde 30 mg prednizon al\u0131yor ve kar\u015f\u0131l\u0131\u011f\u0131 olan deksametazon dozuna ihtiya\u00e7 duyuyor.<\/p>\n<p>\\[ D_{\\text{prednizon}} = 30 \\times \\frac{5}{5} = 30 \\text{ mg} \\]<\/p>\n<p>\\[ D_{\\text{deksametazon}} = 30 \\times \\frac{0.75}{5} = 4.5 \\text{ mg} \\]<\/p>\n<p><strong>Sonu\u00e7:<\/strong> 30 mg prednizon = 30 mg prednizon e\u015fde\u011feri = g\u00fcnde tek doz 4,5 mg deksametazon. Ayn\u0131 d\u00f6n\u00fc\u015f\u00fcm, 120 mg hidrokortizon veya 24 mg metilprednizolon de\u011ferini de verir.<\/p>\n<p>\n\r\n<\/section>\n<h2>Hesaplay\u0131c\u0131 nas\u0131l kullan\u0131l\u0131r?<\/h2>\n<ol>\n<li><strong>\u0130la\u00e7<\/strong> a\u00e7\u0131l\u0131r men\u00fcs\u00fcn\u00fc a\u00e7\u0131n ve d\u00f6n\u00fc\u015f\u00fcm\u00fc yapmak istedi\u011finiz ilac\u0131 se\u00e7in (\u00f6rne\u011fin Prednizon).<\/li>\n<li>Miktar\u0131 <strong>Doz<\/strong> alan\u0131na mg cinsinden girin. Doz ba\u015f\u0131na miktar\u0131 girin \u2014 hasta g\u00fcnde birka\u00e7 doz al\u0131yorsa ya g\u00fcnl\u00fck toplam\u0131 girin ya da sonucu doz say\u0131s\u0131yla \u00e7arp\u0131n.<\/li>\n<li>Sonu\u00e7lar\u0131n en \u00fcst\u00fcndeki <strong>Prednizon e\u015fde\u011feri dozu<\/strong> de\u011ferini okuyun.<\/li>\n<li>Her ilac\u0131n e\u015fde\u011fer dozunu, glukokortikoid ve mineralokortikoid etki g\u00fcc\u00fcn\u00fc ve biyolojik yar\u0131 \u00f6mr\u00fcn\u00fc g\u00f6rmek i\u00e7in <strong>E\u015fde\u011fer dozlar, etki g\u00fcc\u00fc ve yar\u0131 \u00f6m\u00fcr<\/strong> tablosunu inceleyin. Girdi\u011finiz ila\u00e7 tabloda vurgulan\u0131r.<\/li>\n<li>Tedavide herhangi bir de\u011fi\u015fiklik yapmadan \u00f6nce <strong>D\u00f6n\u00fc\u015f\u00fcm notlar\u0131 ve yasal uyar\u0131<\/strong> b\u00f6l\u00fcm\u00fcn\u00fc okuyun.<\/li>\n<\/ol>\n<h2>Kortikosteroid e\u015fde\u011ferli\u011fi nedir?<\/h2>\n<p>Sistemik kortikosteroidlerin etki g\u00fcc\u00fc birbirinden \u00e7ok farkl\u0131d\u0131r: 0,75 mg deksametazon, kabaca 20 mg hidrokortizon veya 5 mg prednizonla ayn\u0131 antiinflamatuar etkiyi yarat\u0131r. Dozlar\u0131 kar\u015f\u0131la\u015ft\u0131rabilmek i\u00e7in farmakoloji kaynaklar\u0131 her ilac\u0131 ortak bir standart \u00fczerinden \u2014 genellikle prednizon 5 mg cinsinden \u2014 ifade eder. Ortaya \u00e7\u0131kan e\u015fde\u011ferlik tablosu, hekime bir re\u00e7eteyi bir kortikosteroidden di\u011ferine, istenen glukokortikoid etkiyi kaybetmeden (ya da iki kat\u0131na \u00e7\u0131karmadan) aktarma imk\u00e2n\u0131 verir.<\/p>\n<p>E\u015fde\u011ferlik g\u00fcnl\u00fck pratikte de \u00f6nemlidir: beyin \u00f6demi olan bir hastada prednizondan deksametazona ge\u00e7mek, hidrokortizon replasman\u0131n\u0131 prednizolone \u00e7evirmek ya da ara\u015ft\u0131rma ve steroid g\u00fcvenli\u011fi k\u0131lavuzlar\u0131ndaki dozlar\u0131 kar\u015f\u0131la\u015ft\u0131rmak \u2014 bu k\u0131lavuzlar \u00e7o\u011funlukla prednizon e\u015fde\u011feri miligram cinsinden yaz\u0131l\u0131r.<\/p>\n<p>Antiinflamatuar e\u015fde\u011ferlik ancak kar\u015f\u0131la\u015ft\u0131rman\u0131n <em>tek<\/em> bir eksenidir. Sonu\u00e7, glukokortikoid etkisinin ayn\u0131 kald\u0131\u011f\u0131n\u0131 s\u00f6yler; ancak ilac\u0131n ne kadar s\u00fcre etkili oldu\u011fu (yar\u0131 \u00f6m\u00fcr hidrokortizonda 8\u201312 saatten betametazonda 36\u201372 saate kadar de\u011fi\u015fir) ya da mineralokortikoid (tuz ve su tutucu) aktivitesi hakk\u0131nda bir \u015fey s\u00f6ylemez. Bu iki fark, aritmetik do\u011fru olsa bile ila\u00e7 de\u011fi\u015fikli\u011finin klinik sonucunu de\u011fi\u015ftirir.<\/p>\n<p>Ayn\u0131 nedenden \u00f6t\u00fcr\u00fc g\u00fcnl\u00fck dozlama d\u00fczeni de \u00e7o\u011funlukla ilaca g\u00f6re de\u011fi\u015fir: hidrokortizon ve kortizon 2\u20133 b\u00f6l\u00fcnm\u00fc\u015f dozda verilir, orta etki s\u00fcreli ila\u00e7lar g\u00fcnde bir ya da iki kez, deksametazon ya da betametazon ise uzun yar\u0131 \u00f6m\u00fcrleri nedeniyle g\u00fcnde bir kez veya daha seyrek verilir.<\/p>\n<h2>Standart kortikosteroid e\u015fde\u011ferlik tablosu<\/h2>\n<table>\n<thead>\n<tr>\n<th>\u0130la\u00e7<\/th>\n<th>Prednizon 5 mg'a denk gelen doz<\/th>\n<th>Glukokortikoid etki g\u00fcc\u00fc (hidrokortizon = 1)<\/th>\n<th>Mineralokortikoid etki g\u00fcc\u00fc<\/th>\n<th>Yar\u0131 \u00f6m\u00fcr<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>Hidrokortizon<\/td>\n<td>20 mg<\/td>\n<td>1x<\/td>\n<td>1x (en y\u00fcksek)<\/td>\n<td>K\u0131sa (8\u201312 saat)<\/td>\n<\/tr>\n<tr>\n<td>Kortizon<\/td>\n<td>25 mg<\/td>\n<td>0,8x<\/td>\n<td>0,8x (y\u00fcksek)<\/td>\n<td>K\u0131sa (8\u201312 saat)<\/td>\n<\/tr>\n<tr>\n<td>Prednizon<\/td>\n<td>5 mg<\/td>\n<td>4x<\/td>\n<td>0,6\u20130,8x (orta)<\/td>\n<td>Orta (18\u201336 saat)<\/td>\n<\/tr>\n<tr>\n<td>Prednizolon<\/td>\n<td>5 mg<\/td>\n<td>4x<\/td>\n<td>0,6x (orta)<\/td>\n<td>Orta (18\u201336 saat)<\/td>\n<\/tr>\n<tr>\n<td>Metilprednizolon<\/td>\n<td>4 mg<\/td>\n<td>5x<\/td>\n<td>yakla\u015f\u0131k 0,5x (hafif)<\/td>\n<td>Orta (18\u201336 saat)<\/td>\n<\/tr>\n<tr>\n<td>Triamsinolon<\/td>\n<td>4 mg<\/td>\n<td>5x<\/td>\n<td>yok<\/td>\n<td>Orta (12\u201336 saat)<\/td>\n<\/tr>\n<tr>\n<td>Deksametazon<\/td>\n<td>0,75 mg<\/td>\n<td>25\u201330x<\/td>\n<td>yok<\/td>\n<td>Uzun (36\u201354 saat)<\/td>\n<\/tr>\n<tr>\n<td>Betametazon<\/td>\n<td>0,6 mg<\/td>\n<td>25\u201330x<\/td>\n<td>yok<\/td>\n<td>Uzun (36\u201372 saat)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>Varsay\u0131mlar, s\u0131n\u0131rl\u0131l\u0131klar ve klinik ipu\u00e7lar\u0131<\/h2>\n<ul>\n<li><strong>Yakla\u015f\u0131k, pop\u00fclasyon ortalamas\u0131na dayal\u0131 oranlar.<\/strong> E\u015fde\u011ferlik de\u011ferleri standart farmakoloji kaynaklar\u0131ndan (Goodman &amp; Gilman, USP DI) al\u0131nm\u0131\u015ft\u0131r ve bireysel varyasyonu, karaci\u011fer hastal\u0131\u011f\u0131n\u0131, CYP3A4 inhibit\u00f6rleri veya ind\u00fckleyicileriyle etkile\u015fimleri hesaba katmaz. Prednizonun kendisi de karaci\u011ferde prednizolona d\u00f6n\u00fc\u015fen bir \u00f6n ila\u00e7t\u0131r; belirgin karaci\u011fer yetmezli\u011finde bir\u00e7ok hekim do\u011frudan prednizolon yazar. Karaci\u011fer fonksiyon bozuklu\u011fu <a href=\"https:\/\/wpcalc.com\/tr\/tisbi\/child-pugh-skoru-hesaplama\/\">Child-Pugh skoru<\/a> ile de\u011ferlendirilebilir.<\/li>\n<li><strong>Mineralokortikoid etki birbiriyle de\u011fi\u015ftirilebilir de\u011fildir.<\/strong> Deksametazon, betametazon ve triamsinolon neredeyse hi\u00e7 sodyum tutmaz. Bir hidrokortizon replasman\u0131 hastas\u0131n\u0131 bunlardan birine \u2014 ya da tersi y\u00f6nde \u2014 ge\u00e7irmek, prednizon e\u015fde\u011feri say\u0131lar\u0131 uysa bile e\u015fde\u011fer bir replasman tedavisi <em>de\u011fildir<\/em>. Tuz tutulumundan ka\u00e7\u0131n\u0131lmas\u0131 gereken durumlarda g\u00fc\u00e7l\u00fc ve uzun etkili ila\u00e7lar bilin\u00e7li olarak tercih edilir.<\/li>\n<li><strong>Etki s\u00fcresi farkl\u0131d\u0131r.<\/strong> E\u015fde\u011fer miligramlar, HPA aks\u0131 bask\u0131lanmas\u0131n\u0131n e\u015fde\u011fer bir s\u00fcrede kalaca\u011f\u0131n\u0131 garanti etmez; uzun etkili ila\u00e7lar hipotalamus\u2013hipofiz\u2013adrenal aks\u0131 belirgin bi\u00e7imde daha uzun s\u00fcre bask\u0131lar.<\/li>\n<li><strong>Uygulama yoluna \u00f6zg\u00fc dozlama ve \u00f6zel protokoller.<\/strong> Tablo enteral ve parenteral sistemik kullan\u0131m i\u00e7in ge\u00e7erlidir. \u0130ntraartik\u00fcler, inhale, topikal ve intralesyonel kortikosteroidler kendi dozlama kurallar\u0131na uyar; deksametazon supresyon testi \u015femalar\u0131 gibi \u00f6zel protokoller bu e\u015fde\u011ferli\u011fin kapsam\u0131 d\u0131\u015f\u0131ndad\u0131r. Kortizon \u00e7o\u011funlukla kortizon asetat olarak listelenir, \u00e7\u00fcnk\u00fc ana bile\u015fik karaci\u011ferde hidrokortizona d\u00f6n\u00fc\u015fene dek b\u00fcy\u00fck \u00f6l\u00e7\u00fcde inaktiftir.<\/li>\n<li><strong>T\u0131bbi tavsiye de\u011fildir.<\/strong> Hastan\u0131n tedavisini de\u011fi\u015ftirmeden \u00f6nce her d\u00f6n\u00fc\u015f\u00fcm\u00fc yerel eczac\u0131l\u0131k kaynaklar\u0131n\u0131z ve \u00fcr\u00fcn prospekt\u00fcs\u00fcyle kar\u015f\u0131la\u015ft\u0131rarak do\u011frulay\u0131n.<\/li>\n<\/ul>\n<p>Benzer doz d\u00f6n\u00fc\u015f\u00fcm\u00fc i\u015flemleri i\u00e7in <a href=\"https:\/\/wpcalc.com\/tr\/tisbi\/mme-hesaplayici-morfin-miligram-esdegeri\/\">MME opioid d\u00f6n\u00fc\u015f\u00fcm hesaplay\u0131c\u0131s\u0131na<\/a>, <a href=\"https:\/\/wpcalc.com\/tr\/tisbi\/ilac-yari-omru\/\">ila\u00e7 yar\u0131 \u00f6m\u00fcr hesaplay\u0131c\u0131s\u0131na<\/a> ya da <a href=\"https:\/\/wpcalc.com\/tr\/tisbi\/cocuk-parasetamol-tylenol-doz-hesaplama\/\">\u00e7ocuklar i\u00e7in parasetamol doz hesaplay\u0131c\u0131s\u0131na<\/a> g\u00f6z at\u0131n.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Sistemik kortikosteroidler aras\u0131ndaki (prednizon, deksametazon, hidrokortizon vb.) doz d\u00f6n\u00fc\u015f\u00fcm\u00fc yap\u0131n. \u0130la\u00e7 ve doz girin; prednizon e\u015fde\u011feri dozu ile etki g\u00fcc\u00fc ve yar\u0131 \u00f6m\u00fcr\u00fc i\u00e7eren tam d\u00f6n\u00fc\u015f\u00fcm tablosunu g\u00f6r\u00fcn.<\/p>\n","protected":false},"author":3168,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[11],"tags":[60],"class_list":["post-4162","post","type-post","status-publish","format-standard","hentry","category-tisbi","tag-farmakoloji"],"acf":[],"_links":{"self":[{"href":"https:\/\/wpcalc.com\/tr\/wp-json\/wp\/v2\/posts\/4162","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wpcalc.com\/tr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wpcalc.com\/tr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wpcalc.com\/tr\/wp-json\/wp\/v2\/users\/3168"}],"replies":[{"embeddable":true,"href":"https:\/\/wpcalc.com\/tr\/wp-json\/wp\/v2\/comments?post=4162"}],"version-history":[{"count":0,"href":"https:\/\/wpcalc.com\/tr\/wp-json\/wp\/v2\/posts\/4162\/revisions"}],"wp:attachment":[{"href":"https:\/\/wpcalc.com\/tr\/wp-json\/wp\/v2\/media?parent=4162"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wpcalc.com\/tr\/wp-json\/wp\/v2\/categories?post=4162"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wpcalc.com\/tr\/wp-json\/wp\/v2\/tags?post=4162"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}