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Carboplatin AUC Dose Calculator

This calculator determines the appropriate dose of carboplatin chemotherapy based on the Calvert formula using patient-specific data such as gender, age, weight, serum creatinine, and the target AUC. It’s a useful tool for oncologists and pharmacists to personalize cancer treatment by estimating the Glomerular Filtration Rate (GFR) and calculating the precise carboplatin dosage.

Carboplatin AUC Dose Calculator

Input Fields
years
mg/dL
mg/ml/min
If enabled, the result will update automatically when you change any value.

Calvert Formula for Carboplatin Dose

Formula
\[\text{GFR}_{\text{Male}} = \left( \frac{140 – \text{age}}{\text{serum creatinine}} \right) \times \left( \frac{\text{weight (kg)}}{72} \right) \]\[\text{GFR}_{\text{Female}} = \left( \frac{140 – \text{age}}{\text{serum creatinine}} \right) \times 0.85 \times \left( \frac{\text{weight (kg)}}{72} \right) \]\[\text{Carboplatin Dose} = \text{Target AUC} \times (\text{GFR} + 25)\]

Explanation:

  • GFR is estimated using the Cockcroft-Gault equation.
  • The Calvert formula calculates carboplatin dosage based on GFR and a desired AUC (area under the concentration-time curve).
  • Gender affects the GFR factor (0.85 for females).

The Calvert formula is widely used in oncology to calculate carboplatin dosage based on renal function and target AUC. This ensures safe and effective dosing, especially important due to carboplatin’s nephrotoxicity. The input includes gender (for GFR adjustment), age, weight, and serum creatinine to estimate GFR. The final dose is tailored by multiplying GFR + 25 by the target AUC. For example, if a 60-year-old woman weighing 65 kg has a serum creatinine of 1.0 mg/dL and the target AUC is 5, her GFR would be calculated and then used to determine the appropriate dose.

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